BRAIN BLOOD FLOW EXAMINATION WITH HIGH-FLOOR MRI-PERFUSION DURING THE ATTACK OF MIGRAINE WITHOUT AURA
Abstract
The main goal of our study was to gain knowledge on blood supply changes during an attack in patients with migraine without aura using contrast-enhanced perfusion-weighted MRI (PWI). Standard MRI, and PWI were performed twice: during an attack (in all three cases) and in between attacks (in two cases). Three females with long history of migraine without aura were observed. Cerebral blood volume (CBV), mean transit time of the contrast bolus (MTT), and cerebral blood flow (CBF) were calculated using Functool package. All three cases produced similar local MR perfusion changes that included reduced CBV and decreased CBF without any change in MTT. Cerebral blood supply decrease observed during migraine attack is reversible and absent during headache-free interval. Transient perfusion abnormalities occurring during recurrent attacks and confirmed by PWI may serve as one of the mechanisms causing the small subcortical white matter lesions.
About the Authors
M. I. Koreshkina
Center of treatment of headache. «Scandinavia» clinic (ООО «AVA-PETER»), Saint-Petersburg
Russian Federation
Russian Federation
A. D. Khalikov
ООО «International clinic MEDEM», STbSMA n.a. I.I. Mechnikov, Saint-Petersburg
Russian Federation
Russian Federation
Yu. V. Nazinkina
Institute of Human Brain Russian Academy of Science, Saint-Petersburg
Russian Federation
Russian Federation
V. V. Osipova
Scientific Investigational Center of First MSMU n.a. I.M. Sechenov; Russian Society of Headache Investigation, Moscow
Russian Federation
Russian Federation
A. V. Amelin
Saint-Petersburg State Medical University n.a. I.P. Pavlov
Russian Federation
Russian Federation
E. A. Kosmacheva
International Medical Center «Sogaz», Saint-Petersburg
Russian Federation
Russian Federation
References
1. Боль: руководство для врачей и студентов / под ред. акад. РАМН Н.Н. Яхно. М. 2009; 304 с.
2. Первичные головные боли. Практическое руководство / В.В. Осипова, Г.Р. Табеева. М. 2007; 60 с.
3. Agarwal Sh., Magu S., Kamal K. Reversible white matter abnormalities in a patient with migraine. Neurology India, 2008; 56 (2): 182-185.
4. Belvís R., Ramos R., Villa C., Segura C., Pagonabarraga J., Ormazabal I., Kulisevsky J. Brain apparent water diffusion coefficient magnetic resonance image during a prolonged visual aura. Headache. 2010 Jun; 50 (6): 1045-9.
5. Cooney B.S., Grossman R.I., Farber R.E., Goin J.E., Galetta S.L. Frequency of magnetic resonance imaging abnormalities in patients with migraine. Headache 1996; 36: 616-21
6. Fazekas F., Koch M., Schmidt R., Offenbacher H., Payer F., Freidl W. et al. The prevalence of cerebral damage varies with migraine type: a MRI study. Headache 1992; 32: 287-91.
7. Ferbert A., Busse D., Thron A. Microinfarction in classic migraine? A study with magnetic resonance imaging findings. Stroke 1991; 22: 1010-14.
8. Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition, Cephalalgia. 2004; 45; 582-9.
9. Igarashi H., Sakai F., Kan S., Okada J., Tazaki Y. Magnetic resonance imaging of the brain in patients with migraine. Cephalalgia 1991; 11: 69-74.
10. Kapinos G., Fischbein N.J., Zacharchuk G. Maigraine-like Headchae with Visual Deficit and Perfusion Abnormality on MRI. Neurology 74, May 25. 2010; 1743-45.
11. Kato Y., Araki N., Matsuda H., Ito Y., Suzuki C. Arterial spin-labeled MRI study of migraine attacks treated with rizatriptan J. Headache Pain. 2010 Jun; 11 (3) :255-8.
12. Kruit M.C., van Buchem M.A., Launer L.J., Terwindt G.M., Ferrari M.D. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: The population-based MRI CAMERA study Cephalalgia February. 2010; 30: 129-136.
13. Kruit M.C., van Buchem M.A., Hofman P.A., Bakkers J.T., Terwindt G.M., Ferrari M.D. Migraine as a risk factor for subclinical brain lesions. JAMA 2004; 291: 427-34.
14. Masuzaki M., Utsunomiya H., Yasumoto S., Mitsundomo A. A Case of hemiplegic Migraine in Childhood: Transient Unilateral Hyperperfusion revealed by Perfusion MR Imaging and MR Angiography. Am. J. Neuroradiol. 2002; 22: 1795-1797.
15. Moskowitz M.A., Buzzi M.G., Sakas D.E., Linnik M.D. Pain mechanisms underlying vascular headaches. Paris. 1989; 145:181-193.
16. Oberndorfer S., Wober C., Nasel C. et al. Familial hemiplegic migraine: fol¬low-up findings of diffusion-weighted magnetic resonance imaging (MRI), perfusion-MRI and [99mTc] HMPAO-SPECT in a patient with prolonged hemiplegic aura. Cephalalgia. 2004; 24: 533-39.
17. Pavese N., Canapicchi R., Nuti A., Bibbiani F., Lucetti C., Collavoli P. et al. White matter MRI hyperintensities in a hundred and twenty-nine consecutive migraine patients. Cephalalgia. 1994; 14: 342-5.
18. Pietrobon D. Migraine: new molecular mechanisms. Neuroscientist. 2005; 11 (4): 373-386.
19. Poreter A., Gladstone J.P., Dodick D.W. Migraine and white matter hyper intensities. Curr. Pain Headache. 2005; 9: 289-95.
20. Relja G., Granato A., Ukmar M., Ferretti G., Antonello R.M., Zorzon M. Persistent aura without infarction: decription of the first case studied with both brain SPECT and perfusion MRI. Cephalalgia. 2005 Jan; 25 (1): 56-9.
21. Rocca M.A., Ceccarelli A., Falini A., Tortorella P. et all. Diffusion tension magnetic resonance imaging at 3.0 tesla shows subtle cerebral grey matter abnormalities in patient with migraine. J. Neurol. Neurosrg. Psychiatry 2006; 77: 686-689.
22. Sanchez del Rio M., Bakker D., Wu O., Agosti R., Mitsikostas D.D., Ostergaard L. Wells Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia. 1999 Oct; 19 (8): 701-7.
23. Schooman G.G., van der Grond J., Kortmann C., van der Greest R.J., Terwindt G.M., Ferrari M.D. Migraine headache is not associated with cerebral or meningeal vasodilation 3T agnetic resonance angiography study. Brain. 2008; 131: 2192-2200.
24. Swartz R.H., Kern R.Z. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol. 2004; 61: 1366-8.
25. Welch K.M.A. Contemporary Concepts of Migraine Pathogenesis. Neurology. 2003; 61 (4): 2-8.
26. Ziegler D.K., Batnitzky S., Barter R., McMillan J.H. Magnetic resonance image abnormality in migraine with aura. Cephalalgia. 1991; 11: 147-50.
Review
For citations:
Koreshkina M.I., Khalikov A.D., Nazinkina Yu.V., Osipova V.V., Amelin A.V., Kosmacheva E.A. BRAIN BLOOD FLOW EXAMINATION WITH HIGH-FLOOR MRI-PERFUSION DURING THE ATTACK OF MIGRAINE WITHOUT AURA. Epilepsy and paroxysmal conditions. 2012;4(4):12-17. (In Russ.)
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