ELECTRIC CLINICAL SEMIOLOGY AND CHRONOLOGIC FEATURES OF EPILEPTIC SEIZURES, ASSOCIATED WITH FOCAL EPILEPSY IN CHILDREN WITH STRUCTURAL CHANGES IN BRAIN AND BENIGN EPILEPTIFORM PATTERNS ON EEG
Abstract
Study is dedicated to investigation of clinical, electroencephalographic features and chronologic peculiarities of epileptic seizures, associated with focal epilepsy in children with structural changes of brain and benign epileptiformic patterns on EEG. We observed 61 patients at age of 3-22 years old (medium age 11,64 years±4,54). Our study demonstrated the prevalence of secondary generalized seizures (40,9% of cases), focal clonic seizures (37,7% of cases), seizures, coming from occipital cortex. Epileptic seizures were observed at night time (85,3% of cases). In 65,6% of cases seizures were associated only with dream (periods of asleeping, dream and awakening) and were not occuring in wakefulness. In 19,7% of patients seizures occurred in dream as well as in wakefulness. Most often (in 54,1% of patieпts) rare seizures, occurring several time in an year (31,2% of cases), or in single cases in whole period of disease (22,9%).
About the Authors
K. Yu. Mukhin
Institute of Children’s Neurology and Epilepsy named after Svyatitel Luka, Moscow
Russian Federation
Russian Federation
M. B. Mironov
Institute of Children’s Neurology and Epilepsy named after Svyatitel Luka, Moscow
Russian Federation
Russian Federation
K. S. Borovikov
Institute of Children’s Neurology and Epilepsy named after Svyatitel Luka, Moscow
Russian Federation
Russian Federation
N. Yu. Borovikova
Institute of Children’s Neurology and Epilepsy named after Svyatitel Luka, Moscow
Russian Federation
Russian Federation
References
1. Алиханов А.А. Методы нейровизуализации в диагностике эпилепсии у детей: в кн. Эпилептология детского возраста под ред. А.С. Петрухина. М. 2000; 407-500.
2. Зенков Л.Р. Утяжеление течения эпилепсии, связанное с противосудорожной фармакотерапией. Журнал Неврологии и Психиатрии им. С.С. Корсакова. 2005; 105 (10): 52-54.
3. Карлов В.А. Эпилепсия. М. 1990; 336 с.
4. Мухин К.Ю. Височная эпилепсия. Журнал неврологии психиатрии. 2000; 100 (9): 48-57.
5. Мухин К.Ю. Доброкачественные эпилептиформные нарушения детского возраста и их специфичность. К.Ю. Мухин, А.С. Петрухин, Л.Ю. Глухова. Эпилепсия: атлас электро-клинической диагностики. М. 2004; 277-288.
6. Мухин К.Ю., Миронов М.Б., Боровиков К.С., Петрухин А.С. Фокальная эпилепсия детского возраста со структурными изменениями в мозге и доброкачественными эпилептиформными паттернами на ЭЭГ (ФЭДСИМ-ДЭПД) (предварительные результаты). Русский журнал детской неврологии. 2010. V (1): 3-17.
7. Мухин К.Ю., Миронов М.Б., Тысячина М.Д., Алиханов А.А., Петрухин А.С. Электро-клиническая характеристика больных симптоматической фокальной эпилепсией с феноменом вторичной билатеральной синхронизации на ЭЭГ. Русский журнал детской неврологии. 2006; 1 (1): 6-17.
8. Мухин К.Ю., Петрухин А.С., Миронов М.Б. Эпилептические синдромы. Диагностика и терапия. Справочное руководство для врачей. М. 2008; 223 с.
9. Мухин К.Ю., Петрухин А.С.. Идиопатические формы эпилепсии: систематика, диагностика, терапия. М. 2000; 176-192.
10. Петрухин А.С., Мухин К.Ю., Благосклонова Н.К., Алиханов А.А. Эпилептология детского возраста. М. 2000; 623 с.
11. Aicardi J. & Chevrie J.J. Convulsive status epilepticus in infants and children. Epilepsia. 1970; 11: 187-197.
12. Ambrosetto G. Unilateral opercular macrogyria and benign childhood epilepsy with centrotemporal (rolandic) spikes: report of a case. Epilepsia. 1992 May-Jun; 33 (3) :499-503.
13. Beaussart M. Benign epilepsy of children with rolandic (centrotemporal) paroxysmal foci: a clinical entity. Study of 221 cases. Epilepsia. 1972.
14. Belcastro V, Arnaboldi M, Taborelli A, Prontera P. Induction of epileptic negative myoclonus by addition of lacosamide to carbamazepine. Epilepsy Behav. 2011 Mar; 20 (3): 589-90.
15. Ben-Zeev B, Kivity S., Pshitizki Y., Watemberg N., Brand N., Kramer U. Congenital hydrocephalus and continuous spike wave in slow sleep – a common association? J. Child Neurol. 2004; 19 (2): 129-134.
16. Callenbach P.M., Bouma P.A., Geerts A.T., Arts W.F., Stroink H., Peeters E.A., van Donselaar C.A., Peters A.C., Brouwer O.F. Long term outcome of benign childhood epilepsy with centrotemporal spikes: Dutch Study of Epilepsy in Childhood. Seizure. 2010 Oct; 19 (8): 501-6.
17. Caraballo R.H., Cersosimo R., Fejerman N. Symptomatic focal epilepsies imitating atypical evolutions of idiopathic focal epilepsies in childhood. In: Eds.: N. Fejerman, R.H. Caraballo. Benign focal epilepsies in infancy, childhood and adolescence. J.L., UK. 2007; 221-242.
18. Chi W.M., Chua K.S., Kong K.H. Phenytoininduced asterixis-uncommon or underdiagnozed? Brain Inj. 2000; 14 (9): 847-50.
19. Doose H. EEG in childhood epilepsy. Hamburg, John Libbey. 2003; 191-243.
20. Doose H., Baier W.K. Benign partial epilepsy and related conditions: multifactorial pathogenesis with hereditary impairment of brain maturation. Eur. J. Pediatr. 1989; 149: 152-158.
21. Dreifuss F. Classification and recognition of seizures. Clin. Ther. 1985; 7 (2): 240-245.
22. Engel J.Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: Report of the ILAE Task Force on Classification and Terminology. Epilepsia. 2001; 42(6): 796-803.
23. Fejerman N., Caraballo R.H. Definition of syndromes, seizure types and nosologic spectrum. In: Eds.: N. Fejerman, R.H. Caraballo. Benign focal epilepsies in infancy, childhood and adolescence. J.L., UK. 2007; 3-13.
24. Gregory D.L., Wong P.K. Topographical analysis of the centrotemporal discharges in benign rolandic epilepsy of childhood. Epilepsia. 1984 Dec; 25 (6): 705-11.
25. Guerrini R., Genton P., Bureau M. и соавт. Multilobar polymicrogiria, intractable drop attack seizures, and sleep-related electrical status epilepticus. Neurology. 1998; 51: 504- 512.
26. Guzzetta F., Battaglia D., Veredice Ch., Donvito V., Pane M., Lettori D., Chiricozzi F., Chieffo D., Tartaglione T., Dravet Ch. Earlythalamic injury associated with epilepsy and continuous spike – wave during slow sleep. Epilepsia. 2005;46 (6): 889-900.
27. Hahn A., Fischenbeck A., Stephani U. Induction of epileptic negative myoclonus by oxcarbazepine in symptomatic epilepsy. Epileptic Disord. 2004; 6: 271-4.
28. Luders H., Lesser R.P., Dinner D.S., Morris H.H. III. Benign focal epilepsy of childhood. In: Luders H, Lesser RP, ed. Epilepsy: electroclinical syndrome. London. 1987; 303-46.
29. Luders H.-O., Noachtar S. Epileptic seizures. Pathophysiology and clinical semiology. Churchill Livingstone. N.Y. 2000. 796 p.
30. Nanba Y, Maegaki Y. Epileptic negative myoclonus induced by carbamazepine in a child with BECTS. Benign epilepsy with centrotemporal spikes. Pediatr. Neurol. 1999; 21: 664-7.
31. Parmeggiani L., Seri S., Bonanni P., Guerrini R. Electrophysiological characterization of spontaneous and carbamazepine-induced epileptic negative myoclonus in benign childhood epilepsy with centro-temporal spikes. Clin. Neurophysiol. 2004; 115: 50-8.
32. Sadler R.M. The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis: clinical features and differential diagnosis. In: Advances in neurology. 97. Intractable epilepsies. Eds.: W.T. Blume. Lippincott, Philadelphia. 2006; 27-37.
33. Shirasaka Y, Mitsuyoshi I. A case of epileptic negative myoclonus: therapeutic considerations. Brain. Dev. 1999; 21: 209-12.
34. Young R.R., Shahani B.T. Asterixis: one type of negative myoclonus. In: S. Fahn, C.D. Marsden, M.H. Van Woert, editors. Myoclonus. Advances in neurology. N.Y. 1986; 43:137-56.
For citation:
Mukhin K.Yu., Mironov M.B., Borovikov K.S., Borovikova N.Yu. ELECTRIC CLINICAL SEMIOLOGY AND CHRONOLOGIC FEATURES OF EPILEPTIC SEIZURES, ASSOCIATED WITH FOCAL EPILEPSY IN CHILDREN WITH STRUCTURAL CHANGES IN BRAIN AND BENIGN EPILEPTIFORM PATTERNS ON EEG. Epilepsy and paroxysmal conditions. 2012;4(4):18-25. (In Russ.)
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