IMPACT OF ANTIEPILEPTIC DRUGS ON COGNITIVE FUNCTIONS: FOCUS ON PERAMPANEL
Abstract
Cognitive problems in epilepsy have a multifactorial origin with etiology, seizures, and the «central» side-effects of drug treatment being involved. Cognitive side effects of antiepileptic drugs (AEDs) have been demonstrated to be one of the most important tolerability problems in chronic AED treatment, especially in children with epilepsy. Memory impairments, mental slowing, and attentional deficits are the most frequently reported ones. Neuropsychological profiles of AEDs are important considerations for treatment selection, particularly in children and adolescents. In evaluating studies of the cognitive effects of AEDs we must follow an evidence-based approach, but in the majority of cases, specific data on cognitive functions in children and adolescents with epilepsy are not yet available. A randomized double blind trial on cognitive effects of adjunctive perampanel for partial-onset seizures is cited (Meador K. F. et al, 2015) and discussed. In this trial adjunctive perampanel did not have any significant overall negative cognitive effect and was improving episodic memory in adolescent patients with inadequately controlled partial-onset seizures.
About the Author
E. D. Belousova
The Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
References
1. Instruction on medical use of the drug Faykompa (perampanel). PL-002200 (in Russian).
2. Aldenkamp A., Besag F., Gobbi F. et al. Psychiatric and Behavioural Disorders in Children with Epilepsy (ILAE Task Force Report): Adverse cognitive and behavioural effects of antiepileptic drugs in children. Epileptic Disord. 2016; 18 (1): 55-67.
3. Eddy C. M., Rickards H. E., Cavanna A. E. The cognitive impact of antiepileptic drugs. Ther Adv Neurol Disord. 2011; 4 (6): 385-407.
4. French J., Krauss G. L., Biton M. D. et al. Adjunctive perampanel for refractory partialonset seizures: randomized Phase III study 304. Neurology. 2012; 79 (6): 589-596.
5. French J. A., Krauss G. L., Wechsler R. T. et al. Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy. A randomized trial. Neurology. 2015 Sep 15; 85 (11): 950-7.
6. Guerrini R., Rosati A., Segieth J., Pellacan S., Bradshaw K., Giorgi L. A randomized phase III trial of adjunctive zonisamide in pediatric patients with partial epilepsy Epilepsia. 2013; 54 (8): 1473-80
7. Hermann B., Meador K. I, Gaillard W. D., Cramer J. A . Cognition across the lifespan: Antiepileptic drugs, epilepsy, or both? Epilepsy & Behavior. 2010; 17: 1-5.
8. Ijff D. M., Aldenkamp A. Cognitive sideeffects of antiepileptic drugs in children. In Handbook of Clinical Neurology, Vol. 111 (3rd series); Pediatric Neurology Part I. Ed.: O. Dulac, M. Lassonde, and H. B. Sarnat, 2013; 707-718.
9. Levisohn P. M., Mintz M., Hunter S. J. et al. Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized, double-blind, placebo-controlled, noninferiority trial. Epilepsia. 2009; 50: 2377-2389.
10. Meador K. F., Yang H., Pina-Garza J. E. et al. Cognitive effects of adjunctive perampanel for partial-onset seizures: A randomized trial. Epilepsia. 2015: 1-9,
11. Mula M. Recent and future antiepileptic drugs and their impact on cognition: what can we expect? Expert Rev. Neurother. 2012; 12 (6): 667-671
12. Rogawski MA. AMPA receptors as a molecular target in epilepsy therapy. Acta Neurol Scand. 2013; 127 (197): 9-18.
For citation:
Belousova E.D. IMPACT OF ANTIEPILEPTIC DRUGS ON COGNITIVE FUNCTIONS: FOCUS ON PERAMPANEL. Epilepsy and paroxysmal conditions. 2016;8(3):6-10. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.3.006-010
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