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The prevalence of depression (D) in patients with epilepsy (PE) is quite high and 12-37% due to common neurobiological structural and morphological  and neurotransmitter  mechanisms underlying  these  diseases.  Depression  negatively affects the quality of life and control of seizures  in PE is associated  with a high risk of suicidality in PE, the disease is poorly diagnosed  the PE shall be appointed and rarely antidepressants  (AD) for the treatment  D in PE.

Materials  and Methods. The aim of our prospective observational study with an active control was to evaluate the clinical efficacy and safety  of AD the second  generation – of escitalopram in the treatment  of depressive  disorders in 30 PE with D. The control group consisted  of 30 PE not receiving AD. Evaluation of the effectiveness of treatment in PE with D was carried out at three points (baseline, after 3 and 6 months  of treatment  AD) by depression  rating score using psychometric scales and scales assessing the overall clinical impression  of the gravity of the violations.

Results.  In the PED group, treated with AD significantly decreased the values of D, there was a decrease in the severity and frequency of seizures, improvement  in the overall clinical impression,  while distinct trends in these indicators in the comparative group were note.

Conclusion. Our findings confirm the need for early detection  of D in PE and destination AD with a harmonious profile of efficacy and safety.

About the Authors

L. V. Lipatova
St. Petersburg V. M. Bekhterev Psychoneurological Research Institute
Russian Federation

Lipatova Lyudmila Valentinovna – MD, PhD, Principal Researcher,  Head of the Department  of treatment  of patients  with organic  mental  disorders  and  epilepsy.

Ul. Bekhtereva, 3, St. Petersburg, Russia, 192019. Tel.: +7(812)4127280.  e-mail:

B. G. Butoma
St. Petersburg V. M. Bekhterev Psychoneurological Research Institute
Russian Federation

Butoma Boris Georgievitch – MD, PhD, leading researcher of the department  of the psychosocial  rehabilitation of psychiatric patients.

Ul. Bekhtereva,  3, St. Petersburg, Russia, 192019. Tel.: +7(812)4127280.  e-mail:

T. V. Kapustina
St. Petersburg V. M. Bekhterev Psychoneurological Research Institute
Russian Federation

Kapustina Tatiana Vladimirovna – MD, researcher of the Department of treatment  of patients with organic mental disorders and epilepsy.

Ul. Bekhtereva, 3, St. Petersburg, Russia, 192019. Tel.: +7(812)4127280.


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Supplementary files

For citation: Lipatova L.V., Butoma B.G., Kapustina T.V. THE CHOICE OF ANTIDEPRESSANTS FOR THE TREATMENT OF DEPRESSIVE DISORDERS ASSOCIATED WITH EPILEPSY. Epilepsia and paroxyzmal conditions. 2016;8(3):34-44.

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