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POSSIBILITIES OF TIC HYPERKINESIA THERAPY USING ANTIСONVULSANTS

https://doi.org/10.17749/2077-8333.2016.8.3.045-051

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Abstract

Objective: to evaluate and compare the clinical efficacy of topiramate and levetiracetam in the treatment of tic disorders.

Materials and  methods. We assessed the effectiveness of 1-2 mg/kg topiramate and up to 30 mg/kg levetiracetam in 17 tic patients aged 10 to 17 years old. Clinical evaluation of hyperkinesia severity and surface electromyography (EMG) were recorded before receiving the drug and later after 6 weeks of treatment. The clinical severity was assessed by Yale Global Tic Severity Scale (YGTSS, 1989). The control group consisted  of 15 healthy children of comparable sex and age.

Results.  Topiramate and levetiracetam  significantly reduced  the  hyperkinesia,  tics  severity  according to  Yale Scale (p<0.05), and the prevalence of firing activity on EMG when registering hyperkinesia from different muscle groups. The maximum  effect was obtained in the topiramate treatment group (p<0.05).

Conclusion. The study has shown the clinical efficacy of anticonvulsants in the treatment of tics in children.

About the Authors

V. P. Zykov
Russian Medical Academy of Postgraduate Education
Russian Federation

Zykov Valery Petrovich – MD, Professor, Head of Department of Pediatric Neurology.

Ul. Barrikadnaya 2/1, Moscow, Russia, 125995. Tel.: +7(495)4966212.  E-mail: zykov_vp@mail.ru



E. A. Kashirina
City Children’s polyclinic № 110
Russian Federation

Kashirina  Elmira Agasalimovna  – Chief Physician  of GBUZ  MCP No. 110.

Ul. Dekabristov 39, Moscow,  Russia,127490. Tel.: +7(499)2049262.  E-mail: dgp110@yandex.ru



Yu. V. Naugolnykh
City Children’s polyclinic № 110
Russian Federation

Naugolnykh Yulia Valerievna – PhD., Head of the Department of Neurology of GBUZ MCP No. 110.

Ul. Dekabristov 39, Moscow, Russia, 127490. Tel.: +7(499)2010638.  E-mail: julia-nv@mail.ru



References

1. Antonov I. P., Shan’ko G. G. Hyperkinesia in children. Questions of etiology, pathogenesis, treatment [Giperkinezy u detei. Voprosy etiologii, patogeneza, lecheniya (in Russian)]. Minsk. 1975; 213 s.

2. Belova E. I. Fundamentals of neuropharmacology [Osnovy neirofarmakologii (in Russian)]. Moscow. 2006; 176 s.

3. Burygina A. D., Andreeva M. K., Kukhnina T. M., Bogdanova L. A. Vopr. kurortologii, fizioterapii i lecheb. fiz. kul’tury. 1993; 5: 42-46.

4. Vidal, reference medicinal products – electronic directory. vidal.ru›drugs/ baclosan_ _1616. Accessed: 06.04.2016.

5. Zenkov L. R., Ronkin M. A. Functional diagnosis of nervous diseases [Funktsional’naya diagnostika nervnykh zabolevanii (in Russian)]. Moscow. 2011; 488 s.

6. Zykov V. P. Childhood Tiki [Tiki detskogo vozrasta (in Russian)]. Moscow. 2002; 163 s.

7. Levin O. S. Tic hyperkinesis. Ex trapyramidal disorders: A guide to diagnosis and treatment. Ed. VN Stock, IA Ivanova-Smolenskaya [Tikoznye giperkinezy. Ekstrapiramidnye rasstroistva: Rukovodstvo po lecheniyu i diagnostike. Pod red. V. N. Shtoka, I. A. Ivanovoi-Smolenskoi (in Russian)]. Moscow. 2002; 313-325; 327-355.

8. Shan’ko G. G. Generalized tick (disease Gilles de la Tourette’s syndrome) in children and adolescents: guidelines [Generalizovannyi tik (bolezn’ Zhill’ de lya Turetta) u detei i podrostkov: metodicheskie rekomendatsii (in Russian)]. Minsk. 1990; 29 s.

9. Electromyography. Workshop on nervous diseases and neurosurgery. nevro-enc. ru›dop-metody…jelektromiografija.html. Accessed: 06.04.2016.

10. Yusevich Yu. S. Electromyography in the clinic of nervous diseases [Elektromiografiya v klinike nervnykh boleznei (in Russian)]. Moscow. 1958; 128.

11. Bamard E. A., Skolnick P., Olsen R. W. et al. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acid A receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 1998; 50 (2): 291-313.

12. Bushara K. O., Malik T., Exonder R. E. The effect of Levetiracetam on essential tremor. Neurology. 2005; 64: 1078-1080.

13. Costa E. From GABAA receptor diversity emerges a unified vision of GABA-ergic inhibition. Annu. Rev. Pharmacol. Toxicol. 1998; 38: 321-350.

14. Dooley M., Plosker G. L. Levetiracetam. A review of its adjunctive use in the partial onself seizures. Drags. 2000; 60: 871-893.

15. Glass G. A., Stankiewics L., Mithoefer A. et al. Levetiracetam forseizures after liver transplantation. Neurology. 2005; 64: 1084-1085.

16. Leckman M. A., Riddle M. T., Hardin S. I., Ort K. l., Swartz J. Stevenson The Yale Global Tic Severity Scale; initial testing of a clinical – rated scale of tic severity. Am Acad Child Adolesc Psychiatry. 1989; 28: 566-573.

17. Yang C. S., Zhang L. N., Zeng L. N., Huang L., Liu Y. T. Topiramate for Tourette’s syndrome in children a meta-analysis. Pediatr. Neurol. 2013 Nov; 49 (5).


For citation:


Zykov V.P., Kashirina E.A., Naugolnykh Y.V. POSSIBILITIES OF TIC HYPERKINESIA THERAPY USING ANTIСONVULSANTS. Epilepsy and paroxysmal conditions. 2016;8(3):45-51. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.3.045-051

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