Epilepsia and paroxysmal conditions

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Objective: to evaluate and compare the clinical efficacy of topiramate and levetiracetam in the treatment of tic disorders.

Materials and  methods. We assessed the effectiveness of 1-2 mg/kg topiramate and up to 30 mg/kg levetiracetam in 17 tic patients aged 10 to 17 years old. Clinical evaluation of hyperkinesia severity and surface electromyography (EMG) were recorded before receiving the drug and later after 6 weeks of treatment. The clinical severity was assessed by Yale Global Tic Severity Scale (YGTSS, 1989). The control group consisted  of 15 healthy children of comparable sex and age.

Results.  Topiramate and levetiracetam  significantly reduced  the  hyperkinesia,  tics  severity  according to  Yale Scale (p<0.05), and the prevalence of firing activity on EMG when registering hyperkinesia from different muscle groups. The maximum  effect was obtained in the topiramate treatment group (p<0.05).

Conclusion. The study has shown the clinical efficacy of anticonvulsants in the treatment of tics in children.

About the Authors

V. P. Zykov
Russian Medical Academy of Postgraduate Education
Russian Federation

Zykov Valery Petrovich – MD, Professor, Head of Department of Pediatric Neurology.

Ul. Barrikadnaya 2/1, Moscow, Russia, 125995. Tel.: +7(495)4966212.  E-mail:

E. A. Kashirina
City Children’s polyclinic № 110
Russian Federation

Kashirina  Elmira Agasalimovna  – Chief Physician  of GBUZ  MCP No. 110.

Ul. Dekabristov 39, Moscow,  Russia,127490. Tel.: +7(499)2049262.  E-mail:

Yu. V. Naugolnykh
City Children’s polyclinic № 110
Russian Federation

Naugolnykh Yulia Valerievna – PhD., Head of the Department of Neurology of GBUZ MCP No. 110.

Ul. Dekabristov 39, Moscow, Russia, 127490. Tel.: +7(499)2010638.  E-mail:


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For citation:

Zykov V.P., Kashirina E.A., Naugolnykh Y.V. POSSIBILITIES OF TIC HYPERKINESIA THERAPY USING ANTIСONVULSANTS. Epilepsia and paroxysmal conditions. 2016;8(3):45-51. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)