MATHEMATICAL MODELING OF EPILEPTOGENESIS PROCESS IN DIFFERENT AGE GROUPS Kalinin V. A.
Abstract
Goal. To assess the state of epileptic system using mathematical modeling to monitor the effectiveness of the therapy of epilepsy in various age group.
Materialy and methods. It conducts research on visual evoked potentials facing checkerboard pattern in patients with various forms of epilepsy in the young and the elderly. We used the original method of mathematical analysis of the results.
Results. A study of evoked potentials to evaluate the stability of neurodynamic system in terms of the risk of an epileptic seizure. Obtained significant differences in the calculated indicators of a group of young patients with cerebral morphofunctional immaturity and a group of elderly patients with involutional changes. Normal values should be regarded as the ratio of positive and negative component (Sp / Sn) from 0.5 to 3.0. More than 3.0 determined a high risk of seizures in patients with brain immaturity, below 0.5 – the risk of seizures in patients with severe cerebral involutional changes. Conclusion.Using the algorithm described in clinical practice as a supplementary budget method with the routine EEG and video-EEG monitoring for epilepsy will predict an individual patient and change pharmacotherapy due time for the rapid achievement of remission counter. The process of generating an epileptic fit in each age group can be described with the use of the theory of unstable systems.
About the Authors
V. A. Kalinin
Samara State Medical University
Russian Federation
Russian Federation
Kalinin Vladimir Anatolyevich – MD, D. Med. Sci., Prof. of the Department of neurology and neurosurgery.
Ul. Chapaevskaya, 89, Samara, Russia, 443099. Tel. +7(846)9561684. E-mail: vkalinin7@rambler.ru
I. A. Poverennova
Samara State Medical University
Russian Federation
Russian Federation
Poverennova Irina Evgenievna – MD, D. Med. Sci., Prof., head of the Department of neurology and neurosurgery.
Ul. Chapaevskaya, 89, Samara, Russia, 443099. Tel. +7(846)9561684. E-mail: samaranevr@mail.ru
E. M. Beketova
Samara State Medical University
Russian Federation
Russian Federation
Beketova Elisaveta Michailovna – MD, PhD student of the Department of neurology and neurosurgery.
Ul. Chapaevskaya, 89, Samara, Russia, 443099. Tel. +7(846)9561684. E-mail: samaranevr@mail.ru
M. A. Gromakovskaya
Samara State Medical University
Russian Federation
Russian Federation
Gromakovskaya Maria Aleksandrovna – MD, resident of the Department of neurology and neurosurgery.
Ul. Chapaevskaya, 89, Samara, Russia, 443099. Tel. +7(846)9561684. E-mail: samaranevr@mail.ru
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Review
For citations:
Kalinin V.A., Poverennova I.A., Beketova E.M., Gromakovskaya M.A. MATHEMATICAL MODELING OF EPILEPTOGENESIS PROCESS IN DIFFERENT AGE GROUPS Kalinin V. A. Epilepsy and paroxysmal conditions. 2016;8(3):74-83. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.3.074-083
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