Epilepsy and paroxysmal conditions

Advanced search


Full Text:


Syndromes with continuous spikes and waves during sleep (CSWS) are being actively studied now. Etiological factors include both genetic causes and structural brain disorders; frequently – the damage of the thalamus, and congenital malformations. In most cases, the persistence of CSWS pattern leads to a neurocognitive dysfunction. Two mechanisms of the intellectual regression are supposed: a violation of brain maturation processes and the effect of the remote inhibition. The most effective treatment is considered to be a combination of hormones and antiepileptic drugs. It is often possible to restore a normal level of child development in case of the early diagnosis and rational therapeutic tactics. However, if more than 18 months has passed since the onset of seizures, as a rule, intellectual functions can’t be improved.

About the Authors

O. A. Shidlovskaya
FSBE HEN. I. Pirogov RNRMU MOH Russia
Russian Federation

postgraduates of the department Nevrology, Neurosurgery and Medical Genetics,

Neurologist of the Research Clinical Institute of Pediatrics,

ul. Ostrovityanova, 1, Moscow, 117997

E. D. Belousova
FSBE HEN. I. Pirogov RNRMU MOH Russia
Russian Federation

MD, Professor, Honored Doctor of the Russian Federation, Department psychoneurology Epileptology and Research Clinical Institute,

ul. Ostrovityanova, 1, Moscow, 117997


1. Ermolenko N.A., Ermakov A.Yu., Buchneva I.A., Uvarova M.V., Zakharova E. I. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2010 (11): 10-14.

2. Bebek N., Gürses C., Baykan B., Gökyiğit A. Lack of prominent cognitive regression in the long-term outcome of patients having Electrical Status Epilepticus During Sleep with different types of epilepsy syndromes. Clinical EEG and Neuroscience. 2015; 46 (3): 235-242.

3. Berg A. T., Berkovic S. F., Brodie M. J., Buchhalter J., Cross J.H., van Emde Boas W., Engel J., French J., Glauser T.A., Mathern G.W., Moshé S. L., Nordli D., Plouin P.,Scheffer I. E. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAECommission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr;51(4):676-85.

4. Buzatu M., Bulteau C., Altuzarra C., Dulac O., Bogaert P.V. Corticosteroids as treatment of epileptic syndromes with continuous spikewaves du ring slow-wave sleep. Epilepsia. 2009; 50 (7): 68-72.

5. Caraballo R., Fortini S., Flesler S., Pasteris М.С., Caramuta L., Portuondo E. Encephalopathy with status epilepticus during sleep: Unusual EEG patterns. Seizure. 2015; 25: 117-125.

6. Caraballo R., Veggiotti P., Kaltenmeier М.С., Piazza Е., Gamboni В.,Avaria М.F., Noli D., Adi J., Cersosimo R. Encephalopathy with status epilepticus during sleep or continuous spikes and waves during slow sleep syndrome: A multicenter, long-term follow-up study of 117 patients. Epilepsy Research. 2013; 105: 164-173.

7. Fernandez I.S., Chapman K. E., Peters J.M., Harini C., Rotenberg A., Loddenkemper T. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Hindawi Publishing Corporation. Epilepsy Research and Treatment. 2013; Article ID 583531:12.

8. Fernandez I.S., Loddenkemper T., Peters J.M., Sanjeev V., Kothare S.V. Electrical Status Epilepticus in Sleep: Clinical Presentation and Pathophysiology. Review Article. Pediatric Neurology. 2012; 47: 390-410.

9. Fortini S., Corredera L., Pastrana A. L., Reyes G., Fasulo L., Caraballo R.H. Encephalopathy with hemi-status epilepticus during sleep or hemi-continuous spikes and waves during slow sleep syndrome: A study of 21 patients. Seizure. 2013; 22: 565-571.

10. Galanopoulou A.S, Bojko A, Lado F, Moshe S. L. The spectrum of neuropsychiatric abnormalities associated with electrical status epilepticus in sleep. Brain and Development. 2000; 22: 279-95.

11. Hughes J.R. A review of the relationships between Landau–Kleffner syndrome, electrical status epilepticus during sleep, and continuous spike–waves during sleep. Epilepsy & Behavior. 2011; 20: 247-253.

12. Kramer U., Sagi L., Goldberg-Stern H., Zelnik N., Nissenkorn A., Ben-Zeev B. Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). Epilepsia. 2009; 50: 1517-24.

13. Loddenkemper T., Fernґandez I.S., and Peters J.M. Continuous spike and waves during sleep and electrical status epilepticus in sleep. Journal of Clinical Neurophysiology. 2011; 28 (2): 154-164.

14. Nickels K., Wirrell E. Electrical Status Epilepticus in Sleep. Elsevier Inc. Seminars in Pediatric Neuroogyl. 2008; 15: 50-60.

15. Patry G., Lyagoubi S., Tassinari C.A. Subclinical “electrical status epilepticus” induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol. 1971 Mar;24(3):242-52.

16. Peltola M. E., Liukkonen E. et al. The effect of surgery in encephalopathy with electrical status epilepticus during sleep. Epilepsia. 2011; 52 (3): 602-609.

17. Pesántez-Ríos G., Martínez-Bermejo A., Arcas J., Merino-Andreu M., UgaldeCanitrot A. The atypical developments of rolandic epilepsy are predictable complications. Revista de Neurologia. 2015; 61 (3): 106-113.

18. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia. 1989 Jul-Aug; 30(4):389-99.

19. Scheltens-de Boer M. Guidelines for EEG in encephalopathy related to ESES/CSWS in children. Epilepsia. 2009; V.50 (Suppl 7); P.13-7.

20. Schmitt B. Sleep and Epilepsy Syndromes. Neuropediatrics. 2015; 46: 171-180.

21. Singhal N.S., Sullivan J. E. Continuous Spike-Wave during Slow Wave Sleep and Related Conditions. ISRN Neurology. 2014; Article ID 619079:6.

22. Striano P., Capovilla G. Epileptic Encephalopathy with Continuous Spikes and Waves During Sleep. Epilepsy (CW Bazil, section editor). CurrNeurolNeurosci Rep. 2013; 13: 360.

23. . Supekar K., Uddin L.Q., Prater K., Amin H., Greicius M.D., Menon V. Development of functional and structural connectivity within the default mode network in young children. Neuroimage. 2010; 52: 290-301.

24. Uliel-Sibony S., Kramer U. Benign childhood epilepsy with Centro-Temporal spikes (BCECTSs), electrical status epilepticus in sleep (ESES), and academic decline – How aggressive should we be? Epilepsy & Behavior. 2015; 44: 117-120.

25. Yuan Q., Li F., Zhong H. Early diagnosis, treatment and prognosis of epilepsy with continuous spikes and waves during slow sleep. Int J. Clin.Exp Med. 2015; 8 (3): 4052-4058.

26. Yilmaz S., Serdaroglu G., Akcay A., Gokben S. Clinical characteristics and outcome of children with electrical status epilepticus during slow wave sleep. J PediatrNeurosci. 2014; 9 (2): 105-9.


For citations:

Shidlovskaya O.A., Belousova E.D. EPILEPSY SYNDROMES WITH CONTINIUOS SPIKE AND WAVE ACTIVITY DURING SLEEP. Epilepsy and paroxysmal conditions. 2016;8(4):58-66. (In Russ.)

Views: 1077

ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)