Epilepsia and paroxysmal conditions

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Syndromes with continuous spikes and waves during sleep (CSWS) are being actively studied now. Etiological factors include both genetic causes and structural brain disorders; frequently – the damage of the thalamus, and congenital malformations. In most cases, the persistence of CSWS pattern leads to a neurocognitive dysfunction. Two mechanisms of the intellectual regression are supposed: a violation of brain maturation processes and the effect of the remote inhibition. The most effective treatment is considered to be a combination of hormones and antiepileptic drugs. It is often possible to restore a normal level of child development in case of the early diagnosis and rational therapeutic tactics. However, if more than 18 months has passed since the onset of seizures, as a rule, intellectual functions can’t be improved.

About the Authors

O. A. Shidlovskaya
FSBE HEN. I. Pirogov RNRMU MOH Russia
Russian Federation

postgraduates of the department Nevrology, Neurosurgery and Medical Genetics,

Neurologist of the Research Clinical Institute of Pediatrics,

ul. Ostrovityanova, 1, Moscow, 117997

E. D. Belousova
FSBE HEN. I. Pirogov RNRMU MOH Russia
Russian Federation

MD, Professor, Honored Doctor of the Russian Federation, Department psychoneurology Epileptology and Research Clinical Institute,

ul. Ostrovityanova, 1, Moscow, 117997


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For citation:

Shidlovskaya O.A., Belousova E.D. EPILEPSY SYNDROMES WITH CONTINIUOS SPIKE AND WAVE ACTIVITY DURING SLEEP. Epilepsia and paroxysmal conditions. 2016;8(4):58-66. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)