Epilepsy and paroxysmal conditions

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The article presents modern data on the use of perampanel in antiepileptic drug therapy resistant epilepsy in routine clinical practice in adolescents. Despite the well-developed diagnostics and treatment of epilepsy system, about onethird of patients with newly diagnosed disease is resistent to medical therapy. When you select a combination of AEDs for children and adolescents should be borne in mind that school performance can largely predetermine their future. In this regard, the most feared cause such adverse events (AEs) as cognitive, neuropsychological, psychiatric and behavioral disorders. In the review perampanel demonstrates efficacy and safety, including among adolescents. There were shown the prospects of the usage of perampanel as add-on therapy of focal seizures with or without secondary generalization and a clinical case of application perampanel a patient with refractory epilepsy in adolescence.

About the Authors

S. G. Burd
Pirogov Russian NationalResearch Medical University; Scientific and Practical Center of Pediatric psychoneurology Department of Health
Russian Federation

MD, Professor of the department of neurology, neurosurgery and medical genetics, the medical faculty,

ul. Ostrovityanova, 1, Moscow, 117997

M. B. Mironov
Training Institute of the Federal Medical and Biological Agency; Scientific and Practical Center of Pediatric psychoneurology Department of Health
Russian Federation

PhD, Associate Prof. of the department of clinical physiology and functional diagnostics,

Volokolamskoe s., 91, Moscow 125371

M. M. Gunchenko
Scientific and Practical Center of Pediatric psychoneurology Department of Health
Russian Federation

deputy director of the outpatient work,

Michurinsky Prospect, 74, Moscow, 119602

M. N. Sarzhina
Scientific and Practical Center of Pediatric psychoneurology Department of Health
Russian Federation

head of the department of medical rehabilitation,

Michurinsky Prospect, 74, Moscow, 119602


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For citations:

Burd S.G., Mironov M.B., Gunchenko M.M., Sarzhina M.N. PERAMPANEL IN THE TREATMENT OF REFRACTORY EPILEPSY IN EVERYDAY CLINICAL PRACTICE IN ADOLESCENTS. Epilepsy and paroxysmal conditions. 2016;8(4):84-90. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)