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Perinatal hypoxic-ischemic encephalopathy (HIE) is a one of common cause of damage to neonatal CNS. Electroencephalography (EEG) has diagnostic value for choice of therapeutic interventions and predicting of outcomes. Sarnat classification is used EEG findings. EEG-monitoring and amplitude-integrated EEG could be used in Intensive Care Unit to provide information about the prognosis for the infant. Comprehensive assessment based on EEG data and serum determination of biochemical markers of brain damage could be feasible for identifying risk of subsequent brain damage that might benefit for treatment and predict of outcomes after HIE. Further studies in this area are clearly needed.

About the Author

D. V. Blinov
FSBE HE N. I. Pirogov RNRMU MOH Russia
Russian Federation

MD, PhD,

ul. Ostrovitianova, 1, Moscow, 117997


1. Barashnev Yu.I., Kulakov V. I. Infants at high risk. New diagnostic and therapeutic technologies [Novorozhdennye vysokogo riska. Novye diagnosticheskie i lechebnye tekhnologii (in Russian)]. Moscow. 2006; 528 s.

2. Blinov D.V. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2013; 4: 15-19.

3. Blinov D.V. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / Pharmacoeconomics . Modern pharmacoeconomics and pharmacoepidemiology. 2014; 7 (1): 40-45.

4. Blinov D.V. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2014; 1: 6-11.

5. Volodin N.N. Perinatology. Milestones. Development prospects. Acts referred to in the SMU [Perinatologiya. Istoricheskie vekhi. Perspektivy razvitiya. Aktovaya rech’ v RGMU (in Russian)]. Moscow. 2006; 48 s.

6. Ivanov D.O., Kapustina O. G., Mavropulo T. K., Obolonskii A. I., Surkov D.N. Clinical guidelines on the provision of medical aid to children born in the 22-27 weeks of gestation (the project) [Klinicheskie rekomendatsii po okazaniyu meditsinskoi pomoshchi detyam, rodivshimsya v srokakh gestatsii 22-27 nedel’ (proekt) (in Russian)]. Moscow. 2016.

7. Clinical guidelines Edited by Academician. RAS NN Volodin. The amplitude-integrated EEG in the evaluation of the functional state of the central nervous system in newborns of different gestational age [Klinicheskie rekomendatsii pod redaktsiei akad. RAN N.N. Volodina. Amplitudno-integrirovannaya elektroentsefalografiya v otsenke funktsional’nogo sostoyaniya tsentral’noi nervnoi sistemy u novorozhdennykh razlichnogo gestatsionnogo vozrasta. RASPM (in Russian)]. 2015; 40 s.

8. Lebedeva A.V., Khomutov V. E., Ershov A.V., Guz’ D.V. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions. 2012; 4 (2): 28-33.

9. Pal’chik A.B., Shabalov N.P. Hypoxicischemic encephalopathy newborns [Gipoksicheski-ishemicheskaya entsefalopatiya novorozhdennykh (in Russian)]. Moscow. M. 2013; 288 s.

10. Sidorova I.S., Unanyan A. L., Nikitina N.A., Rzaeva A.A., Kinyakin V.V. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2012; 4: 29-32.

11. Tsybelova E.M. Sibirskii Meditsinskii zhurnal. 2007; 6: 27-31.

12. Yakunin Yu.A., Perminov V.S. Ros. Vest. perinat. i ped. 1993; 38 (2): 20-24.

13. Yakunin Yu.A., Yampol’skaya E.I., Kipnis S. L., Sysoeva I.M. Diseases of the nervous system in infants and young children [Bolezni nervnoi sistemy u novorozhdennykh i detei rannego vozrasta (in Russian)]. Moscow. 1979; 280 s.

14. Abend N.S., Dlugos D. J., Clancy R.R. A review of long-term EEG monitoring in critically ill children with hypoxic-ischemic encephalopathy, congenital heart disease, ECMO, and stroke. Clin Neurophysiol. 2013; 30 (2): 134-142

15. Abend N.S., Gutierrez-Colina A.M., Topjian A.A., et al. Non-convulsive seizures are common in critically ill children. Neurology. 2011; 76: 1071-1077.

16. Abend N.S., Licht D. J. Predicting outcome in children with hypoxic ischemic encephalopathy. Pediatr Crit Care Med. 2008; 9: 32-39.

17. Abend N.S., Topjian A., Ichord R., et al. Electroencephalographic monitoring during hypothermia after pediatric cardiac arrest. Neurology. 2009; 72: 1931-1940.

18. Anderson P. Neuropeptide could be biomarker for stroke. J. Am. Coll. Cardiol. 2012; 60: 346-354.

19. Azzopardi D.V., Strohm B., Edwards A.D., et al. Moderate hypothermia to treat perinatal asphyxia encephalopathy. N Engl J Med. 2009; 361:1349-1358.

20. Basys V., Drazdiene N., Vezbergiene N., Isakova J. Perinatal injury of the central nervous system in Lithuania from 1997 to 2014. Acta Medica Lituanica. 2016. Vol. 23. No. 4. P. 199-205.

21. Cheliout-Heraut F., Sale-Franque F., Hubert P., Bataille J. Cerebral anoxia in near-drowning of children. The prognostic value of EEG. Neurophysiol Clin. 1991; 21: 121-132.

22. de Haan M., Wyatt J.S., Roth S., VarghaKhadem F., Gadian D., Mishkin M. Brain and cognitive-behavioural development after asphyxia at term birth. Dev Sci. 2006; 9: 350-8.

23. de Vries L.S., Toet M.C. Amplitude integrated electroencephalography in the full-term newborn. Clin. Perinatol. 2006; 33: 619-632.

24. George M.M. Neonatal encephalopathy, hypoxic ischemic encephalopathy and subsequent cerebral palsy: etiology, pathology and prevention. Medical Veritas. 2005; 2: 500-506.

25. Gerber P.A., Chapman K. E., Chung S.S., et al. Interobserver agreement in the interpretation of EEG patterns in critically ill adults. J Clin Neurophysiol. 2008; 25: 241-249.

26. Glass H.C. et al. Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury. J. Pediatr. 2009; 155: 318-323.

27. Gunn A. J., Wyatt J.S., Whitelaw A. et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J. Pediatr. 2008; 152 (1): 55-58.

28. Hahn J.S., Olson D.M. Etiology of neonatal seizures. Neo Reviews. 2004; (8): 327.

29. Hallberg B., Grossmann K., Bartocci M., Blennow M. The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment. Acta Paediatrica. 2010; 99 (4): 531-536.

30. Hellstrom-Westas L., Rosen I. Continuous brain-function monitoring: state of the art in clinical practice. Semin. Fetal Neonatal Med. 2006; 11: 503-511.

31. Hirsch L. J., Brenner R. P., Drislane F.W., et al. The ACNS subcommittee on research terminology for continuous EEG monitoring: proposed standardized terminology for rhythmic and periodic EEG patterns encountered in critically ill patients. J Clin Neurophysiol. 2005; 22: 128-135.

32. Holmes G. L. Effects of seizures on brain development: lessons from the laboratory. Pediatr. Neurol. 2005; 33 (1): 1-11.

33. Husain A.M. Electroencephalographic assessment of coma. J Clin Neurophysiol. 2006; 23: 208-220.

34. Jacobs S., Hunt R., Tarnow-Mordi W., Inder T., Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst. Rev. 2007; 4. CD003311.

35. Jette N., Claassen J., Emerson R.G., Hirsch L. J. Frequency and predictors of nonconvulsive seizures during continuous electroencephalographic monitoring in critically ill children. Arch Neurol. 2006; 63: 1750-1755.

36. Kessler S., Topjian A.A., Guterrez-Colina A.M., et al. Short-term outcome prediction by electroencephalographic features in children treated with therapeutic hypothermia after cardiac arrest. Neurocritical Care. 2011; 14: 37-43.

37. Levene M. I., de Vries L.S. Hypoxic-ischemic encephalopathy Fanaroff and Martin’s neonatal-perinatal medicine: diseases of the fetus and infant. Ed. by Fanaroff A.A., Martin R.J, Walsh M.C. 9th ed. 2011; 2 (40): 958-962.

38. Mandel R., Martinot A., Delepoulle F. et al. Prediction of outcome after hypoxicischemic encephalopathy: a prospective clinical and electrophysiologic study. J Pediatr. 2002; 141: 45-50.

39. Miller S.P., Weiss J., Barnwell A. et al. Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology. 2002; 58 (4): 542-548.

40. Mizrahi E.M., Kellaway P. Characterization and classification of neonatal seizures. Neurology. 1987; 37 (12): 1837-1844.

41. Murray D. M., Boylan G. B., Ryan C. A., Connolly S. Early EEG findings in hypoxicischemic encephalopathy predict outcomes at 2 years. Pediatrics. 2009; 124: 459-467.

42. Nishisaki A., Sullivan J. 3rd, Steger B. et al. Retrospective analysis of the prognostic value of electroencephalography patterns obtained in pediatric in-hospital cardiac arrest survivors during three years. Pediatr Crit Care Med. 2007; 8: 10-17.

43. Pressler R.M., Boylan G.B., Morton M. et al. Early serial EEG in hypoxic ischaemic encephalopathy. Clinical Neurophysiology. 2001; 112: 31-37.

44. Ramachandrannair R., Sharma R., Weiss S.K., Cortez M.A. Reactive EEG patterns in pediatric coma. Pediatr Neurol. 2005; 33: 345-349.

45. Roest A., van Bets B., Jorens P.G., Baar I., Weyler J., Mercelis R. The prognostic value of the EEG in postanoxic coma. Neurocrit Care. 2009; 10: 318-325.

46. Ronen G.M. et al. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J. Pediatr. 1999; 134: 71-75.

47. Ronner H. E., Ponten S.C., Stam C. J., Uitdehaag B.M. Inter-observer variability of the EEG diagnosis of seizures in comatose patients. Seizure. 2009; 18: 257-263.

48. Rossetti A.O., Carrera E., Oddo M. Early EEG correlates of neuronal injury after brain anoxia. Neurology. 2012; 78: 796-802.

49. Sanchez S.M., Carpenter J., Chapman K. E. et al. Pediatric ICU EEG Monitoring: Current Resources and Practice in the United States and Canada. J Clin Neurophysiol. 2013; 30 (2): 156-60.

50. Sarnat H.B., Sarnat M.S. Neonatal encephalopathy following fetal distress: A clinical and electroencphalographic study. Arch Neurol. 1976; 33: 698-705.

51. Scher M.S. Neonatal seizures and brain damage. Pediatr. Neurol. 2003; 29 (5): 381-390.

52. Shankaran S., Laptook A.R., Ehrenkranz R.A. et al. Whole-body hypothermia for neonates with hypoxicischemic encephalopathy. N Engl J Med. 2005; 353: 1574-1584.

53. Simbruner G., Mittal R.A., Rohlmann F., Muche R. Systemic hypothermia after neonatal encephalopathy: outcomes of neo. RCT. Pediatrics. 2010; 126: e771-778.

54. Sinclair D.B., Campbell M., Byrne P., Prasertsom W., Robertson C.M.T. EEG and long-term outcome of term infants with neonatal hypoxic-ischemic encephalopathy. Clinical neurophysiology. 1999; 110: 655-659.

55. Spitzmiller R. E., Phillips T., Meinzen-Derr J., Hoath S.B. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxicischemic encephalopathy: a meta-analysis. Journal of Child Neurology. 2007; 22: 1069-1078.

56. Tay S.K., Hirsch L. J., Leary L., Jette N., Wittman J., Akman C. I. Nonconvulsive status epilepticus in children: clinical and EEG characteristics. Epilepsia. 2006; 47: 1504-1509.

57. van Rooij L.G.M., Toet M.C., Osredkar D. et al. Recovery of amplitude integrated electroencephalographic background patterns within 24 hours of perinatal asphyxia. Arch. Dis. Child. Fetal Neonatal Ed. 2005; 90: 245-251.

58. Vasudevan C., Levene M. Epidemiology and aetiology of neonatal seizures. Semin. Fetal Neonatal Med. 2013; 18: 185-191.

59. Williams K., Jarrar R., Buchhalter J. Continuous video-EEG monitoring in pediatric intensive care units. Epilepsia. 2011; 52: 1130-1136.

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