SLEEP DISORDERS IN EPILEPTIC PATIENTS
Abstract
Objective. To investigate the main features of sleep disorders in patients with three main forms of epilepsy and its impact on the quality of life.
Materials and methods. One hundred and fifty patients with different forms of epilepsy (including idiopathic, cryptogenic, and symptomatic) aged 17-64 years were enrolled. The following parameters were evaluated: presence of sleep disorders (estimated using special questionnaires developed by the Somnological Center of the Ministry of Health of the Russian Federation), presence of daytime sleepiness according to the Epworth scale, level of anxiety and depression according to the hospital scale (HADS), quality of life (analyzed using the QOLIE-89 questionnaire).
Results. Patients in all three groups experienced daytime sleepiness, difficulty falling asleep and maintaining sleep at night, problems with final awakening. We found a reliable correlation between the daytime sleepiness at rest or during activities with the subjective sleep characteristics, difficulty falling asleep and maintaining sleep, level of anxiety, and the values from QOLIE-89 questionnaire (quality of life).
Conclusion. Our findings demonstrate the obligatory nature of the circadian rhythm sleep disorders in all three groups of epileptic patients. The differences in the subjective sleep characteristics between the groups (depending on the form of epilepsy: symptomatic/cryptogenic and idiopathic) can be compared with the psychological characteristics of the patients with these forms of epilepsy.About the Authors
V. A. Karlov
A. I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Karlov Vladimir Alekseevich – professor in the Department of Neurology.
20-1 Delegatskaya str., Moscow, 127473
O. S. Inozemtseva
A. I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Inozemtseva Olga Sergeevna – PhD student in the Department of Neurology.
20-1 Delegatskaya str., Moscow, 127473
G. B. Novoselova
A. I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Novoselova Galina Borisovna – PhD student in the Department of Neurology.
20-1 Delegatskaya str., Moscow, 127473
References
1. Bradley V Vaughn. Treatment of sleep disorders in epilepsy. Epilepsy Behavior. October 2002; 3 (5): 1-64.
2. Crespel A., Coubes P., Baldy-Mpulinier M. Sleep influence on seizures and epilepsy effects on sleep in partial frontal and temporal lobe epilepsies. Clin. Neurophysiol. 2002; 111: 54-59.
3. Khatami R., Zutter D., Siegel A., Mathis J., Donati F., Bassetti C. L. Sleep-wake habits and disorders in a series of 100 adult epilepsy patientsA prospective study. Seizure. 2006; 15: 299-306.
4. Vignatelli L., Bisulli F. et al. Excessive daytime sleepiness and subjective sleep quality in patients with nocturnal frontal lobe epilepsy: a case-control study. Epilepsia. 2006; 47 (5): 73-7.
5. Somnology and sleep medicine. National guideline in memory of A. M. Wayne and J. I. Levin. Edited by M. G. Poluektova [Somnologiya i meditsina sna. Natsional’noe rukovodstvo pamyati A. M. Veina i Ya.I. Levina. Pod redaktsiei M. G. Poluektova (in Russian)]. Moscow. 2016; 660 s.
6. Foldvary-Scaefer N. Sleep complaints and epilepsy: The role of seizures, antiepileptic drugs and sleep disorders. J. Clinic. Neurology. 2002; 19: 514-521.
7. Kotagal P., Yardi N. The relationship between sleep and epilepsy. Seminars in Pediatric. Neurology. 2008; 15: 42-49.
8. Bazil C. W. Sleep and Epilepsy. Semin. Neurol. 2002; 22: 321-327.
9. Placidi F., Scalise A., Marciani M. G., Romigi A., Diomedi M., Gili G. L. Effect of antiepileptic drugs on sleep. Clinic. Neurophy. 2000; 111: 115-119.
10. Szaflarski J. P., Szaflarski M. Seizure disorders, depiression, and health-related quality of life. Epilepsy & Behavior. 2004; 5: 50-70.
11. Vendrame M., Yang B. S., Jackson S., Auerbach S. H. Insomnia and Epilepsy: A Questionnaire-Based Study. J Clin Sleep Med. Feb 1, 2013; 9 (2): 141-146.
12. Zohreh Yazdi, Khosro Sadeghniiat-Haghighi et al. Prevalence of Sleep Disorders and their Effects on Sleep Quality in Epileptic Patients. Clin Neurosci. 2013; 4 (1): 36-41.
13. Johns M. W. Anew method of measuring daytime sleepness: the epworth sleepness scale. Sleep. 1991; 14 (6): 540-545.
14. Manni R., Terzaghi M., Arbasino C., Sartori I., Calimberti A., Tartara A. Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and features of the comorbidity. Epilepsia. 2003; 44: 836-840.
15. Piperidou C., Karlovasitou A., Triantafyllou N. Influence of sleep disturbance on quality of life patients with epilepsy. Seizure. 2008; 17: 588-594.
16. Beaulieu-Bonneau S., LeBlanc M. et al. Family history of insomnia in a populationbased sample. Sleep. 2007 Dec; 30 (12): 1739-45.
17. Babu C. S., Satishchandra P., Sinha S., Subbakrishna D. K. Co-morbidities in people living with epilepsy: Hospital based-control study from a resource-poor setting. Epilepsy Research. 2009; 86: 146-152.
18. Senol V., Soyuer F., Arman F., Ozturk A. Influence of fatigue, depression, and demographic, socioeconomic, and clinical variables on quality of life of patients with epilepsy. Epilepsy & Behavior. 2007; 10: 96-104.
19. Sasai T et al. Effects of insomnia and sleep medication on health-related quality of life. Sleep Med. 2010.
For citation:
Karlov V.A., Inozemtseva O.S., Novoselova G.B. SLEEP DISORDERS IN EPILEPTIC PATIENTS. Epilepsy and paroxysmal conditions. 2017;9(1):36-39. (In Russ.) https://doi.org/10.17749/2077-8333.2017.9.1.036-039
Views: 537
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
