Epilepsy and paroxysmal conditions

Advanced search


Full Text:


In this review we discuss clinical significance of using evoked potentials in children with epilepsy and related disorders. This approach has been commonly adapted for practice in pediatric epileptology. In most cases, it serves a neuromonitoring tool to assess the effectiveness of a therapy program and / or its side-effects. In addition, the method of evoked potentials is helpful in testing the central inhibition and excitation balance in different forms of epilepsy. In this respect, we also take a look at the impact of epileptic activity on the function and development of brain regions. The method of evoked potentials may be used for localization of epileptic lesions in children suffering from focal epilepsy. Given the variety of existing modalities of evoked potentials, their safety, painlessness and neuromonitoring qualities, we recommend to expand the use of these techniques in pediatric patients with paroxysmal disorders.

About the Authors

V. B. Voitenkov
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

PhD, Head, the Dpt. of functional diagnostics, Pediatric Research and Clinical Center for Infectious Diseases

Address: ul. Professora Popova, 9, Saint-Petersburg, Russia, 197022. Tel.: +7(812)2343823

E. Yu. Gorelick
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

PhD, Senior research fellow, the Dpt. of neuro-infections and organic lesions of CNS, Pediatric Research and Clinical Center for Infectious Diseases

Address: ul. Professora Popova, 9, Saint-Petersburg, Russia, 197022.

N. V. Skripchenko
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

MD, Honored scientist of the Russian Federation, Professor, Deputy Director, Pediatric Research and Clinical Center for Infectious Diseases

Address: ul. Professora Popova, 9, Saint-Petersburg, Russia, 197022

A. V. Klimkin
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation

Junior researcher, the Dpt. of functional diagnostics, Pediatric Research and Clinical Center for Infectious Diseases

Address: ul. Professora Popova, 9, Saint-Petersburg, Russia, 197022


1. Aminoff M. J. Aminoff’s Electrodiagnosis in Clinical Neurology, Sixth Edition. Philadelphia. 2012; 348 p.

2. Gnezditskii V. V., Piradov M. A. Neurophysiology of coma and consciousness disturbances [Neirofiziologiya komy i narusheniya soznaniya (In Russian)]. Ivanovo. 2015; 528 p

3. Komantsev V. N., Skripchenko N. V., Voitenkov V. B., Savina M. V., Ivanova G. P. Zhurnal infektologii. 2013; 5 (2): 55-62.

4. Zykov V. P., Mosin I. M., Safronov D. L., Izyumova E. B., Stepanishchev I. L., Voronenko O. A. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions. 2009; 1 (1): 14-20.

5. Brazzo D., Di Lorenzo G., Bill P., Fasce M., Papalia G., Veggiotti P., Seri S. Abnormal visual habituation in pediatric photosensitive epilepsy. Clin Neurophysiol. 2011; 122 (1): 16-20.

6. Deryaga I. N., Gnezditskii V. V., Karlov V. A., Kulikova S. N. Prakticheskaya nevrologiya i neiroreabilitatsiya. 2009; 2: 36-41.

7. Zorin R. A., Zhadnov V. A., Lapkin M. M. Rossiiskii mediko-biologicheskii vestnik im. akademika I. P. Pavlova. 2015; 4: 68-73.

8. Shnaider N. A., Kamzalakova N. I., Kryzhanovskaya S. V., Panina Yu. S. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions. 2015; 7 (2): 6-17.

9. Casali R. L., Amaral M. I., Boscariol M., Lunardi L. L., Guerreiro M. M., Matas C. G., Colella-Santos M. F. Comparison of auditory event-related potentials between children with benign childhood epilepsy with centrotemporal spikes and children with

10. temporal lobe epilepsy. Epilepsy Behav. 2016; 59: 111-6.

11. Vlasenko A. N., Miroshnikova E. B., Odintsova G. V. Profilakticheskaya i klinicheskaya meditsina. 2009; 3: 222-225.

12. Tomй D., Sampaio M., Mendes-Ribeiro J., Barbosa F., Marques-Teixeira J. Auditory event-related potentials in children with benign epilepsy with centro- temporal spikes. Epilepsy Res. 2014; 108 (10): 1945-9.

13. Monjauze C., Broadbent H., Boyd S. G., Neville B. G., Baldeweg T. Language deficits and altered hemispheric lateralization in young people in remission from BECTS. Epilepsia. 2011; 52 (8): e79-83.

14. Myatchin I., Lagae L. Impaired spatial working memory in children with well- controlled epilepsy: an event-related potentials study. Seizure. 2011; 20 (2): 143-50.

15. Werner K., Fosi T., Boyd S. G., Baldeweg T., Scott R. C., Neville B. G. Temporal lobe impairment in West syndrome: event-related potential evidence. Ann Neurol. 2015; 77 (1): 47-57.

16. de Freitas Dotto P., Cavascan N. N., Berezovsky A., Sacai P. Y., Rocha D. M., Pereira J. M., Salomгo S. R. Sweep visually evoked potentials and visual findings in children with West syndrome. Eur J Paediatr Neurol. 2014; 18 (2): 201-10.

17. Tsai M. L., Hung K. L., Tsan Y. Y., Tung W. T. Long-term neurocognitive outcome and auditory event-related potentials after complex febrile seizures in children. Epilepsy Behav. 2015; 47: 55-60.

18. Sheppard E., Birca A., Carmant L., Lortie A., Vannassing P., Lassonde M., Lippй S. Children with a history of atypical febrile seizures show abnormal steady state visual evoked potential brain responses. Epilepsy Behav. 2013; 27 (1): 90-4.

19. Japaridze N., Schark M., von-Ondarza G., Boor R., Muhle H., Gerber W., Stephani U., Siniatchkin M. Altered information processing in children with focal epilepsies with and without intellectual disability. Funct Neurol. 2014; 29 (2): 87-97.

20. Filippini M., Boni A., Giannotta M., Pini A., Russo A., Musti M. A., Guerra A.,

21. Lassonde M., Gobbi G. Comparing cortical auditory processing in children with typical and atypical benign epilepsy with centrotemporal spikes: Electrophysiologic

22. evidence of the role of non-rapid eye movement sleep abnormalities. Epilepsia. 2015; 56 (5): 726-34.

23. Lopes R., Simхes M. R., Ferraz L., Leal A. J. The mismatch negativity (MMN) potential as a tool for the functional mapping of temporal lobe epilepsies. Epilepsy Behav. 2014; 33: 87-93.

24. Elkabariti R. H., Khalil L. H., Husein R., Talaat H. S. Speech evoked auditory brainstem response findings in children with epilepsy. Int J Pediatr Otorhinolaryngol. 2014; 78 (8): 1277-80.

25. Plyler E., Harkrider A. W. Serial auditory-evoked potentials in the diagnosis and monitoring of a child with Landau-Kleffner syndrome. J Am Acad Audiol. 2013; 24 (7): 564-71.

26. Major Z. Z. Combined evoked potentials in co-occuring attention deficit hyperactivity disorder and epilepsy. Ideggyogy Sz. 2011; 64 (7-8): 248-56.

27. Wang B., Cai F. C. Polyneuro-electrophysiological studies of myoclonus in children. Zhonghua Er Ke Za Zhi. 2009; 47 (10): 750-6.

28. Sinha S., Satishchandra P., Gayathri N., Yasha T. C., Shankar S. K. Progressive myoclonic epilepsy: A clinical, electrophysiological and pathological study from South India. J Neurol Sci. 2007; 252 (1): 16-23.

29. Lopes R., Cabral P., Canas N., Breia P., Foreid J. P., Calado E., Silva R., Leal A. N170 asymmetry as an index of inferior occipital dysfunction in patients with symptomatic occipital lobe epilepsy. Clin Neurophysiol. 2011; 122 (1): 9-15.

30. Puri V., Sajan P. M., Chowdhury V., Chaudhry N. Cortical excitability in drug naive juvenile myoclonic epilepsy. Seizure. 2013; 22 (8): 662-9.

31. Koudijs S. M., Leijten F. S., Ramsey N. F., van Nieuwenhuizen O., Braun K. P. ateralization of motor innervation in children with intractable focal epilepsy – a TMS and fMRI study. Epilepsy Res. 2010; 90 (1-2): 140-50.

32. Brigo F., Storti M., Benedetti M. D., Rossini F., Nardone R., Tezzon F., Fiaschi A., Bongiovanni L. G., Manganotti P. Resting motor threshold in idiopathic generalized epilepsies: a systematic review with meta-analysis. Epilepsy Res. 2012; 101 (1-2): 3-13.

33. Badawy R. A., Macdonell R. A., Jackson G. D., Berkovic S. F. Can changes in cortical excitability distinguish progressive from juvenile myoclonic epilepsy? Epilepsia. 2010; 51 (10): 2084-8.

34. Lee J. H., Joo E. Y., Seo D. W., Hong S. B. Lateralizing Cortical Excitability in Drug Naпve Patients with Generalized or Focal Epilepsy. J Epilepsy Res. 2015; 5 (2): 75-83.

35. Voitenkov V. B., Kiseleva L. N., Kartashev A. V. Issledovanie vliyaniya del’ta-son indutsiruyushchego peptida na protsessy tsentral’nogo tormozheniya u cheloveka. Vrach-aspirant. 2012; 52 (3-2): 290-294.

36. Pfьtze M., Reis J., Haag A., John D., Hattemer K., Oertel W. H., Rosenow F., Hamer H. M. Lack of differences of motorcortical excitability in the morning as compared to the evening in juvenile myoclonic epilepsy – a study using transcranial magnetic stimulation. Epilepsy Res. 2007; 74 (2-3): 239-42.

37. Chowdhury F. A., Pawley A. D., Ceronie B., Nashef L., Elwes R., Richardson M. P. Motor evoked potential polyphasia: A novel endophenotype of idiopathic generalized epilepsy. Neurology. 2015; 84 (13): 1301-1307.

38. Hйbert-Lalonde N., Carmant L., Major P., Roy M. S., Lassonde M., Saint-Amour D. Electrophysiological Evidences of Visual Field Alterations in Children Exposed to Vigabatrin Early in Life. Pediatr Neurol. 2016. PII: S0887-8994(16)30017-0.

39. Sendrowski K., Sobaniec W., Boćkowski L., Kułak W., Smigielska-Kuzia J. Somatosensory evoked potentials in epileptic children treated with carbamazepine or valproate in monotherapy – a preliminary study. Adv Med Sci. 2010; 55 (2): 212-5.

40. Taeye L. D., Vonck K., Bochove M. V., Boon P., et al. The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy. Neurotherapeutics. 2014; 11 (3): 612-622.

41. Joo E. Y., Kim H. J., Lim Y. H., Ji K. H., Hong S. B. Zonisamide changes unilateral cortical excitability in focal epilepsy patients. J Clin Neurol. 2010; 6 (4): 189-95.

For citation:

Voitenkov V.B., Gorelick E.Y., Skripchenko N.V., Klimkin A.V. EVOKED POTENTIALS IN CHILDREN WITH PAROXYSMAL DISORDERS. Epilepsy and paroxysmal conditions. 2017;9(2):67-73. (In Russ.)

Views: 158

ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)