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DEPRESSIONS IN EPILEPSIA: PREVALENCE, RISK FACTORS, SYMPTOMS AND THERAPY

https://doi.org/10.17749/2077-8333.2017.9.3.047-053

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Abstract

The paper reviews the current data on the risk factors, pathogenesis, psychopathological symptoms and therapy of depression in patients with epilepsy. Depression predominantly occurs in patients with temporal epilepsy. The lateralization of the focus cannot be readily interpreted, although the literature indicates that depression occurs more often with left-sided foci. In their external manifestations, the episodes of depression in epilepsy can be fully the same as in any affective disorder. Treatment of depression is carried out without canceling therapy with antiepileptic drugs; the latter may have different impacts on the course of depression. In this respect, valproate, carbamazepine, oxcarbazepine, and lamotrigine do not exacerbate depression. All of them, despite the differences in their mechanisms of action, have a common component – an increase in the serotonin level in the central nervous system. Among the drugs listed above, valproate is especially beneficial.

About the Authors

V. V. Kalinin
Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky, Health Ministry of Russian Federation
Russian Federation

MD, Professor, Head of the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076



E. V. Zheleznova
Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky, Health Ministry of Russian Federation
Russian Federation

MD, Leading Researcher at the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076



A. A. Zemlyanaya
Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky, Health Ministry of Russian Federation
Russian Federation

PhD, Senior Researcher at the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076



L. V. Sokolova
Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky, Health Ministry of Russian Federation
Russian Federation

PhD, Senior Researcher at the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076



K. Yu. Subbotin
Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky, Health Ministry of Russian Federation
Russian Federation

Junior Researcher at the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076



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For citation:


Kalinin V.V., Zheleznova E.V., Zemlyanaya A.A., Sokolova L.V., Subbotin K.Y. DEPRESSIONS IN EPILEPSIA: PREVALENCE, RISK FACTORS, SYMPTOMS AND THERAPY. Epilepsy and paroxysmal conditions. 2017;9(3):47-53. (In Russ.) https://doi.org/10.17749/2077-8333.2017.9.3.047-053

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)