NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS
Abstract
The majority of epilepsy cases have their onset in childhood. Compared to their peers, many more children with epilepsy suffer from severe neurodevelopmental disorders, including intellectual disability and autism spectrum disorders. In the present report, the incidence of intellectual disability and autism spectrum disorders among children with epilepsy is reviewed. Four types of connection between epilepsy and autism are discussed: these two conditions are independent as they have different etiologies and may co-occur just by chance; epilepsy and autism are associated because both originate from the same genetic defect or from an early CNS damage; autism is caused by the epileptic process, which interferes with the developing brain networks involved in communication and social behavior. Studies demonstrating positive effects of levetiracetam on the behavioral and cognitive functions (memory, attention) in epileptic children are cited.
About the Author
N. N. Zavadenko
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Zavadenko Nikolay Nikolaevich – MD, PhD, Professor and Head, Department of Neurology, Neurosurgery and Medical Genetics, Faculty of Pediatrics.
Ul. Ostrovityanova, 1, Moscow, 117997, Tel.: +7(495)9369452
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Review
For citations:
Zavadenko N.N. NEURODEVELOPMENTAL DISORDERS IN CHILDREN WITH EPILEPSY: INTELLECTUAL DISABILITY AND AUTISM SPECTRUM DISORDERS. Epilepsy and paroxysmal conditions. 2017;9(4):64-71. (In Russ.) https://doi.org/10.17749/2077-8333.2017.9.4.064-071
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