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EFFECTS OF LEVETINOL ON EPILEPTIFORM ACTIVITY OF THE BRAIN IN RATS WITH COBALT-INDUCED EPILEPSY

https://doi.org/10.17749/2077-8333.2018.10.1.052-062

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Abstract

The aim of this study was to evaluate the anti-seizure effect of Levetinol tablet (Geropharm) on the cobalt-induced chronic epilepsy.

Materials and methods. A model of cobalt-induced epilepsy was created by applying cobalt powder to the sensorimotor zone of the rat cortex. The effects of Levetinol were studied at the early stage of the epileptic system (ES) formation (on day 2 after the cobalt application), and then at the stage of fully developed ES (on day 6 after the cobalt application).

Results. The present study showed that at the early stage of ES development, Levetinol at doses of 50 and 200 mg/kg had no statistically significant effect on the development of paroxysmal activity in both primary and secondary epileptic foci: in the ipsi- and contralateral cortex, hypothalamus and hippocampus. On day 6 of the cobalt-induced epilepsy, a significant suppression of paroxysmal activity in the above structures of the brain was observed with the administration of Levetinol at a dose of 200 mg/kg. The most pronounced anti-seizure effect was found in the hippocampus; that was expressed in normalization of the bioelectrical activity and appearance of the regular theta rhythm.

Conclusion. The effects of Levetinol are largely manifested in the hippocampal foci of epileptiform activity and, to a lesser extent, in the cortical foci. 

About the Authors

S. A. Litvinova
V.V. Zakusov Institute of Pharmacology
Russian Federation
8 Baltijskaja Str., 125315 Moscow


T. A. Voronina
V.V. Zakusov Institute of Pharmacology
Russian Federation
8 Baltijskaja Str., 125315 Moscow


L. N. Nerobkova
V.V. Zakusov Institute of Pharmacology
Russian Federation
8 Baltijskaja Str., 125315 Moscow


I. S. Kutepova
V.V. Zakusov Institute of Pharmacology
Russian Federation
8 Baltijskaja Str., 125315 Moscow


G. G. Avakyan
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
1 Ostrovityanova Str., Moscow 117997


G. N. Avakyan
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
1 Ostrovityanova Str., Moscow 117997


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For citation:


Litvinova S.A., Voronina T.A., Nerobkova L.N., Kutepova I.S., Avakyan G.G., Avakyan G.N. EFFECTS OF LEVETINOL ON EPILEPTIFORM ACTIVITY OF THE BRAIN IN RATS WITH COBALT-INDUCED EPILEPSY. Epilepsia and paroxysmal conditions. 2018;10(1):52-62. (In Russ.) https://doi.org/10.17749/2077-8333.2018.10.1.052-062

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)