Characteristics of vascular endothelium in young patients with epilepsy
https://doi.org/10.17749/2077-8333.2018.10.3.014-018
Abstract
The objective was to study the state of vascular walls in young patients at various stages and various courses of epilepsy.
Materialsand methods. We examined 62 patients of young age with focal symptomatic and cryptogenic epilepsy for hanges in their blood vessels. Photoplethysmography combined with a non-invasive diagnostic system (“Angioscan Electronics”, Russia) were used. The patients were divided into 3 groups: 1) patients after a single (first) epileptic seizure; 2) patients with remission; 3) patients with treatment-resistant seizures.
Results. We found no structural changes in their blood vessels. However, the occlusion test showed changes in the functional state of large muscle arteries in all groups of epileptic patients. In addition, changes in microcirculatory beds were detected in patients after a single seizure and in those resistant to treatment. Patients after single epileptic seizures showed the largest changes in small resistance arteries and arterioles.
Conclusion. The results suggest that functional characteristics of vascular endothelium change in young patients suffering from epilepsy.
About the Authors
A. I. Fedin
N I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Fedin Anatoly Ivanovich - MD, PhD, Professor and Head, Department of Neurology, Faculty of Advanced Medical Studies.
1 Ostrovityanova Str., Moscow 117997, tel.: +7(495)370-00-11
E. V. Starykh
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Starykh Elena Vladimirovna - MD, PhD, Professor at the Department of Neurology, Faculty of Advanced Medical Studies.
1 Ostrovityanova Str., Moscow 117997
O. A. Baranova
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Baranova Olga Alexandrovna - PhD (Biology), Head of Laboratory, Department of Neurology, Faculty of Advanced Medical Studies.
1 Ostrovityanova Str., Moscow 117997
A. V. Chekanov
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia
Russian Federation
Russian Federation
Chekanov Andrey Vasilyevich - PhD (Biology), Head of Laboratory, Department of Neurology, Faculty of Advanced Medical Studies.
1 Ostrovityanova Str., Moscow 117997
D. V. Torshin
City Clinical Hospital No. 13 of the Moscow City Health Department
Russian Federation
Russian Federation
Torshin Dmitry Vladimirovich - MD, Neurologist.
1/1 VelozavodskayaStr., Moscow115280
References
1. Fedin A. I., Staryh E. P., Parfenov A. S. et al. Vestnik Rossiyskogo gosudarstvennogo meditsinskogo universiteta (in Russian). 2012; 4: 27-31.
2. Perticone F., Ceravolo R., Pujia A. Prognosticsignificance of endothelial dysfunction in hypertensive patients. Circulation. 2001; 104: 191-196.
3. Yang Z., Ming X. F. Recent advances in understanding endothelial dysfunction in atherosclerosis. Clinical medicine and research. 2006; 4 (1): 53-65.
4. Versari D., Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care. 2009; 32: 314-321.
5. Landmesser U., Hornig B., Drexler H. Endothelial function. A critical determinant in atherosclerosis? Circulation. 2004; 109 (II): 27-33.
6. Talaeva T. V., SHishkin V.V., Vavilova L. L. Bukovinskiy meditsinskiy vestnik (in Russian). 2013; 17 (1): 156-163.
7. Novikova N. A. Vrach (in Russian). 2005; 8: 51-53.
8. Taddei S., Virdis A., Ghiadoni L., et al. Lacidipine restores endothelium-dependent vasodilation in essential hypertensive patients. Hypertension. 1997; 30 (6): 1606-1612.
9. Carratu P., Pourcyrous M., Fedinec A., Leffle r C. W. Parfenova H. Endogenous heme oxygenase prevents impairment of cerebral vascular functions caused by seizures. Am. J. Physiol. Heart Circ. Physiol. 2003; 285: 1148-1157.
10. Parfenova H., Carratu P., Tcheranova D., Fedinec A., Pourcyrous M., Leffler C. W. Epileptic seizures cause extended postictal cerebral vascular dysfunction that is prevented by HO-1 overexpression. Am. J. Physiol. Heart Circ. Physiol. 2005; 288: 2843-2850.
11. Cornford E.M. Epilepsy and the blood brain barrier: endothelial cell responses to seizures. Adv. Neurol. 1999; 79: 845-862.
12. Oby E. Janigro D. The blood-brain barrier and epilepsy. Epilepsia. 2006; 47: 17611774.
13. Parfenova H., Leffler C. W., Tcheranova D., et al. Epileptic seizures increase circulating endothelial cells in peripheral blood as early indicators of cerebral vascular damage. Am J Physiol Heart Circ Physiol. 2010; 298: 1687-1698.
14. Poryadin G. V. Stress and pathology [Stress i patologiya (in Russian)]. Moscow. 2009; 24.
15. Goncharova N. D. Stress Responsiveness of the Hypothalamic-Pituitary-Adrenal Axis: Age-Related Features of the Vasopressinergic Regulation I N. D. Goncharova II Front. Endocrinol (Lausanne). 2013; 4: 26-33.
16. Hankin B. L., Badanes L. S., Watamura S. E. Hypothalamic pituitary adrenal axis dysregulation in dysphoric children and adolescents: Cortisol reactivity to psychosocial stress from preschool through middle adolescence. Biological psychiatry. 2010; 68 (5): 484-490.
17. Bolevich S. B., Voynov V. A. Molecular mechanisms in human pathology [Molekulyarnye mekhanizmy v patologii cheloveka (in Russian)]. Moscow. 2012; 208 s.
18. Chubukov, Zh.A. Problemy zdorov’ya i ekologii (in Russian). 2012; 2 (32): 40-45.
Review
For citations:
Fedin A.I., Starykh E.V., Baranova O.A., Chekanov A.V., Torshin D.V. Characteristics of vascular endothelium in young patients with epilepsy. Epilepsy and paroxysmal conditions. 2018;10(3):14-18. (In Russ.) https://doi.org/10.17749/2077-8333.2018.10.3.014-018
Views: 773
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
