Epilepsy and paroxysmal conditions

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Treatment of patients with prolonged course of medial temporal epilepsy

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Objective. The aim of the study was to evaluate the efficacy of treatment in patients with prolonged duration of medial temporal epilepsy (MTE).

Materials and methods. We studied cases of 93 patients with history of MTE lasted more than 10 years.

Results. This form of epilepsy is often characterized by drug resistance; therefore, patients have to try different medications before the effective one is found (in 12% of cases, patients tried 5-7 different medicines). Nevertheless, in 48.4% of patients, pharmacotherapy is ineffective. According to our findings, patients with an early MTE debut and those with an epileptogenic focus (by EEG / MRI data) in the medial temporal zone are most likely to have treatment-resistant epilepsy.

Conclusion. If the therapy is ineffective, patients should be referred to preoperational examination.

About the Authors

V. E. Kitaeva
A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation
Russian Federation

Kitaeva Varvara Evgenevna – 3rd year student of medical faculty.

20-1 Delegatskaya Str., Moscow 127473

A. S. Kotov
Moscow Regional Research and Clinical Institute
Russian Federation

Kotov Aleksej Sergeevich – Head of the Department of Pediatric Neurology, GBUZ MO MONIKI named after M. F. Vladimirsky; Professor at the Department of Neurology FUV GBUZ MO MONIKI named after M. F. Vladimirsky.

61/2 Shchepkina Str., Moscow 129110


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For citations:

Kitaeva V.E., Kotov A.S. Treatment of patients with prolonged course of medial temporal epilepsy. Epilepsy and paroxysmal conditions. 2018;10(3):31-37. (In Russ.)

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