Preview

Epilepsy and paroxysmal conditions

Advanced search

Treatment of patients with prolonged course of medial temporal epilepsy

https://doi.org/10.17749/2077-8333.2018.10.3.031-037

Full Text:

Abstract

Objective. The aim of the study was to evaluate the efficacy of treatment in patients with prolonged duration of medial temporal epilepsy (MTE).

Materials and methods. We studied cases of 93 patients with history of MTE lasted more than 10 years.

Results. This form of epilepsy is often characterized by drug resistance; therefore, patients have to try different medications before the effective one is found (in 12% of cases, patients tried 5-7 different medicines). Nevertheless, in 48.4% of patients, pharmacotherapy is ineffective. According to our findings, patients with an early MTE debut and those with an epileptogenic focus (by EEG / MRI data) in the medial temporal zone are most likely to have treatment-resistant epilepsy.

Conclusion. If the therapy is ineffective, patients should be referred to preoperational examination.

About the Authors

V. E. Kitaeva
A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation
Russian Federation

Kitaeva Varvara Evgenevna – 3rd year student of medical faculty.

20-1 Delegatskaya Str., Moscow 127473



A. S. Kotov
Moscow Regional Research and Clinical Institute
Russian Federation

Kotov Aleksej Sergeevich – Head of the Department of Pediatric Neurology, GBUZ MO MONIKI named after M. F. Vladimirsky; Professor at the Department of Neurology FUV GBUZ MO MONIKI named after M. F. Vladimirsky.

61/2 Shchepkina Str., Moscow 129110



References

1. Cendes F. Mesial temporal lobe epilepsy syndrome: an updated overview. J. epilepsy clin. neurophysiol. 2005; 11 (3): 141-144.

2. Berg A. T., Shinnar S. Unprovoked seizures in children with febrile seizures: short-term outcome. Neurology. 1996 Aug; 47 (2): 562-8. PubMed PMID: 8757039.

3. Azevedo H., Amato Khaled N., Santos P., Bernardi Bertonha F., Moreira-Filho C. A. Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures. Dis Model Mech. 2018 Jan 29; 11(1). PII: dmm029074. DOI: 10.1242/dmm.029074.PubMed PMID: 29196444; PubMed Central PMCID: PMC5818071.

4. Thom M. Review: Hippocampal sclerosis in epilepsy: a neuropathology review. Neuropathol Appl Neurobiol. 2014 Aug; 40 (5): 520-43. DOI: 10.1111/nan.12150. Review. PubMed PMID: 24762203; PubMed Central PMCID: PMC4265206.

5. Chungath M., Shorvon S. The mortality and morbidity of febrile seizures. Nat Clin Pract Neurol. 2008 Nov; 4 (11): 610-21. DOI: 10.1038/ncpneuro0922. Review. PubMed PMID: 18978801.

6. Kopachev D. N., Shishkina L. V., Bychenko V. G., Shkatova A. M., Golovteev A. L., Troitskiy A. A., Grinenko O. A. Hippocampal sclerosis: pathogenesis, clinical features, diagnosis, and treatment. Zhurnal “Voprosy neirokhirurgii” imeni N. N. Burdenko. 2016; 80 (4): 109-116. DOI: 10.17116/neiro2016804109.

7. Kitaura H., Shirozu H., Masuda H., Fukuda M., Fujii Y., Kakita A. Pathophysiological Characteristics Associated With Epileptogenesis in Human Hippocampal Sclerosis. EBioMedicine. 2018 Mar; 29:38-46. DOI: 10.1016/j.ebiom.2018.02.013. Epub 2018 Feb 21. PubMed PMID: 29478873; PubMed Central PMCID: PMC5925580.

8. Teocchi M. A., D’Souza-Li L. Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis. Mediators Inflamm. 2016; 2016: 8290562. DOI: 10.1155/2016/8290562. Epub 2016 Feb 23. PubMed PMID: 27006531; PubMed Central PMCID: PMC4781997.

9. Donati D., Akhyani N., Fogdell-Hahn A., Cermelli C., Cassiani-Ingoni R., Vortmeyer A., Heiss J. D., Cogen P., Gaillard W. D., Sato S., Theodore W. H., Jacobson S. Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections. Neurology. 2003 Nov 25; 61 (10): 1405-11. PubMed PMID: 14638964; PubMed Central PMCID: PMC4294224.

10. Kotov A. S., Rudenko A. M. Criptogenic and symptomatic temporal epilepsies in adults. Annaly klinicheskoj I ehksperimentalnoj nevrologii. 2009; 3 (2): 9-13.

11. Sander J. W., Shorvon S. D. Epidemiology of the epilepsies. Journal of Neurology, Neurosurgery & Psychiatry. 1996; 61: 433-443.

12. Asadi-Pooya A.A., Stewart G. R., Abrams D. J., Sharan A. Prevalence and Incidence of Drug-Resistant Mesial Temporal Lobe Epilepsy in the United States. World Neurosurg. 2017 Mar; 99: 662-666. DOI: 10.1016/j.wneu.2016.12.074. Epub 2016 Dec 27. Review. PubMed PMID: 28034810.

13. Taylor P. N., Sinha N., Wang Y., Vos S. B., de Tisi J., Miserocchi A., McEvoy A.W., Winston G. P., Duncan J. S. The impact of epilepsy surgery on the structural connectome and its relation to outcome. Neuroimage Clin. 2018 Jan 31; 18: 202-214. DOI: 10.1016/j.nicl.2018.01.028.eCollection 2018. PubMed PMID: 29876245; PubMed Central PMCID: PMC5987798.

14. Kotov A. S., Rudakova I. G., Mukhin K. Yu., Alikhanov A. A., Mironov M. B., Kvaslova N. E. Rasmussens’s encephalitis. Two case reports. Russkij zhurnal detskoj nevrologii. 2009; 4 (2): 42-50.

15. Stefanits H., Springer E., Pataraia E., Baumgartner C., Hainfellner J. A., Prayer D., Weisstanner C., Czech T., Trattnig S. SevenTesla MRI of Hippocampal Sclerosis: An In Vivo Feasibility Study With Histological Correlations. Invest Radiol. 2017 Nov; 52 (11): 666-671. DOI: 10.1097/RLI.0000000000000388.PubMed PMID: 28538339.

16. Von Oertzen J., Urbach H., Jungbluth S. et al. Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. J. Neurol. Neurosurg. Psychiatry. 2002; 73: 643-674.

17. Molugulu N., Gubbiyappa K. S., Vasudeva Murthy C. R., Lumae L., Mruthyunjaya A. T. Evaluation of selfreported medication adherence and its associated factors among epilepsy patients in Hospital Kuala Lumpur. J Basic Clin Pharm. 2016 Sep; 7 (4): 105-109. DOI: 10.4103/0976-0105.189430.PubMed PMID: 27999469; PubMed Central PMCID: PMC5153886.

18. Lee Y. K., Ah Y. M., Choi Y. J., Cho Y. S., Kim K. J., Lee J. Y. Antiepileptic drug adherence and persistence in children with epilepsy attending a large tertiary care children’s hospital. Epileptic Disord. 2016 Dec 1; 18 (4): 408-417. DOI: 10.1684/epd.2016.0871. PubMed PMID: 27818363.

19. Chinnaiyan S., Narayana S., Nanjappa V. P. Adherence to Antiepileptic Therapy in Adults. J Neurosci Rural Pract. 2017 Jul-Sep; 8 (3): 417-420. DOI: 10.4103/jnrp.jnrp_392_16. PubMed PMID: 28694623; PubMed Central PMCID: PMC5488564.

20. Kotov A. S. Compliance in patients with epilepsy. Zhurnal nevrologii i psihiatrii im S. S. Korsakova. 2010; 110 (11): 46-48.

21. Rudakova I. G., Kotov A. S., Belova Yu.A. Topiramate as an example of using generics in the treatment of epilepsy. Zhurnal nevrologii i psihiatrii im S. S. Korsakova. 2011; 111 (3): 38-43.

22. Rudakova I. G., Belova Yu.A., Kotov A. S. Pharmacoresistant epilepsy is treatable. Vestnik ehpileptologii. 2013; 1: 3-7.


For citation:


Kitaeva V.E., Kotov A.S. Treatment of patients with prolonged course of medial temporal epilepsy. Epilepsy and paroxysmal conditions. 2018;10(3):31-37. (In Russ.) https://doi.org/10.17749/2077-8333.2018.10.3.031-037

Views: 83


ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)