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Epilepsy and paroxysmal conditions

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Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index

https://doi.org/10.17749/2077-8333.2018.10.3.038-043

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Abstract

The aim of the study was to assess the course of epilepsy in patients with signs of cranio-cerebral imbalance with a low CSF-cranial index.

Materials and methods. We conducted a prospective analysis of clinical, instrumental and laboratory data from the case histories of 78 patients with epileptic seizures (cryptogenic epilepsy). Group I included 36 patients with normal reserve CSF volumes and physiological values of the CSF-cranial index; these patients received standard multicomponent therapy. Group II was comprised of 42 patients with abnormally small reserve CSF spaces and a lower than normal CSF-cranial index; patients in group II received the same treatment as did patients in group I.

Results. We found a moderate correlation between the head circumference and the values of the CSF-cranial index. A strong correlation between the seizure occurrence rate and the values of the CSF-cranial index was also found (R=0.32, p=0.0043); the seizure rate correlation with the head circumference was less obvious (R=0.11, p=0.037). Most of the patients in group I had bilateral seizures, whereas in patients of group II the seizures were of a mixed character.

Conclusion. The results of this clinical study suggest that the course of epilepsy in patients with a low CSF-cranial index is determined by the severity of anatomical reduction in the CSF dynamics; in most cases of a low CSF-cranial index, the course of epilepsy is severe. These findings should be considered at the starting and the later stages of antiepileptic therapy.

About the Authors

V. I. Larkin
Omsk State Medical University
Russian Federation

Larkin Valery Ivanovich – MD, PhD, Associate Professor, Head of the Department of Neurology and Neurosurgery OSMU, Ministry of Healthcare RF.

12 Lenina Str., Omsk 644099



N. S. Stelmakh
Omsk State Medical University
Russian Federation

Stelmakh Natalia Sergeevna – Correspondence Post-graduate Student, Department of Neurology and Neurosurgery OSMU.

12 Lenina Str., Omsk 644099



References

1. Avakyan G.N., Blinov D.V., Lebedeva A.V., Burd S.G., Avakyan G.G. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2017; 9 (1): 6-25. DOI: 10.17749/2077-8333.2017.9.1.006-025.

2. Gromov S. A., Lipatova L. V., Yakunina O. N. Obozrenie psihiatrii i meditsinskoy psihologii. 2016; (4): 17-24.

3. Fisher R. S., Acevedo C., Arzimanoglou A. et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014; 55: 475-482.

4. Mula M. Epilepsy and Psychiatric Comorbidities: Drug Selection. Curr Treat Opions Neurol. 2017; 19 (12): 11-44.

5. Tully H. M., Dobyns W. B. Infantile hydrocephalus: a review of epidemiology, classification and causes. Eur J Med Genet. 2014; 57 (8): 359-368.

6. Chmutin G. E. Profilakticheskaya i klinicheskaya meditsina. 2005; (4): 120-123.

7. Chmutin G. E., Poshatev K. E., Makarov K. V. et al. Klinicheskaya gerontologiya. 2005; 12: 98-101.

8. Lar’kin V. I. Features of the clinic and surgical treatment of craniocerebral trauma in children with a low cerebrovascular index. PhD diss. [Osobennosti kliniki i hirurgicheskogo lecheniya cherepnomozgovoy travmy u detey s nizkim LKI: avtoref. …kand. med. Nauk (in Russian)] . Omsk. 2000; 16 s.

9. Lar’kin V. I., Ignat’ev YU. T., Lar’kin I. I. Meditsinskaya vizualizatsiya. 2005; 5: 129-133.


For citation:


Larkin V.I., Stelmakh N.S. Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index. Epilepsy and paroxysmal conditions. 2018;10(3):38-43. (In Russ.) https://doi.org/10.17749/2077-8333.2018.10.3.038-043

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)