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Research and development of 2-ethyl-6-methyl-3-oxypyridine succinate nano-form for the treatment of epilepsy

https://doi.org/10.17749/2077-8333.2018.10.4.026-038

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Abstract

The aim is to develop an antiepileptic drug based on polymer nanoparticles with 2-ethyl-6-methyl-3-oxypyridine succinate to facilitate the drug transport through the blood-brain barrier.

Materials and methods. The nano-drug was created using the biologically active substance 2-ethyl-6-methyl-3-hydroxypyridine succinate and polybutyl cyanoacrylate (PBCA) nanoparticles. The advantages of this nano-form over the active ingredient of the same drug were studied using experimental models: the maximum electroshock test (MES), the antagonism test with corazol, models with a cobaltinduced epileptic focus and secondary generalized convulsions, and models of status epilepticus.

Results. The antiseizure effects of the nanoform on the experimental models of epilepsy are identified.

Conclusion. The nano-drug reduces the number of secondary generalized clonic-tonic seizures by 7.8 times; it also reduces 10-fold the animal mortality and diminishes the seizure manifestations that occur in the interictal period of the epileptic status.

About the Authors

G. G. Avakyan
Pirogov Russian National Research Medical University.
Russian Federation

Avakyan Georgii Gagikovich – MD, PhD, Department of Neurology, Neurosurgery and Medical Genetics.

1 Ostrovityanova Str., Moscow 117997.



T. A. Voronina
Zakusov Institute of Pharmacology.
Russian Federation

Voronina Tatyana Aleksandrovna – MD, Professor & Head, Laboratory of Psychopharmacology.

8 Baltijskaja Str., Moscow 125315.



L. N. Nerobkova
Zakusov Institute of Pharmacology.
Russian Federation

Nerobkova Lyubov Nikolaevna – PhD, Senior Research Fellow.

8 Baltijskaja Str., Moscow 125315.



G. N. Avakyan
Pirogov Russian National Research Medical University.
Russian Federation

Avakyan Gagik Norairovich – MD, PhD, Honored Scientist of Russia, Professor at the Department of Neurology, Neurosurgery and Medical Genetics.

1 Ostrovityanova Str., Moscow 117997.


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For citation:


Avakyan G.G., Voronina T.A., Nerobkova L.N., Avakyan G.N. Research and development of 2-ethyl-6-methyl-3-oxypyridine succinate nano-form for the treatment of epilepsy. Epilepsy and paroxysmal conditions. 2018;10(4):26-38. (In Russ.) https://doi.org/10.17749/2077-8333.2018.10.4.026-038

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)