Epilepsy and paroxysmal conditions

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Diagnostic evaluation of drug-resistant insular epilepsy

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About 30% of patients with temporal epilepsy are resistant to antiepileptic drugs; in such cases, surgical treatment is considered to be the best option. Existence of an extra-temporal epileptogenic focus in the insula is a possible cause of seizures after temporal lobe surgery in about 20% of patients. Because of its localization, the anatomical features of the insular lobe, as well as the entire concept of insular epilepsy have not been well documented. Yet, it has been established that the seizures developing from the insular cortex can mimic the paroxysms arising from the temporal lobe. When the insula is involved in the epileptic process, resection of the insular cortex improves the outcome of surgical treatment. Rational and well-based selection of candidates for surgical treatment is of paramount importance for patients with drug-resistant epilepsy. The article presents a review of the up-to-date literature on this matter.

About the Authors

R. G. Khachatryan
Almazov National Medical Research Center.
Russian Federation

Roza G. Khachatryan – PhD Student, Department of Nervous Diseases and Psychiatry.

2 Akkuratova Str., St. Petersburg 197341,

Researcher ID: C-6929-2019.

G. S. Ibatova
Joint-stock company “National Center of Neurosurgery”.

Gauhar S. Ibatova – MD, PhD, Neurologist, Department of Pediatric Neurosurgery.

34/1 Turan Avenue, Astana 010000.

T. M. Alekseeva
Almazov National Medical Research Center.
Russian Federation

Tatiana M. Aleksseva – MD, PhD, Head of the Department of Nervous Diseases and Psychiatry.

2 Akkuratova Str., St. Petersburg 197341,

W. A. Khachatryan
Almazov National Medical Research Center.
Russian Federation

William A. Khachatryan – MD, PhD, Professor of Neurosurgery, Head of the Department of Pediatric Neurosurgery.

2 Akkuratova Str., St. Petersburg 197341,

Scopus ID: 55633841500; Researcher ID: G-4002-2018.


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For citations:

Khachatryan R.G., Ibatova G.S., Alekseeva T.M., Khachatryan W.A. Diagnostic evaluation of drug-resistant insular epilepsy. Epilepsy and paroxysmal conditions. 2018;10(4):83-93. (In Russ.)

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