Epilepsy and paroxysmal conditions

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Efficacy of levetiracetam monotherapy in epilepsy associated with benign epileptiform discharges of childhood

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Aim. To analyze efficacy of levetiracetam monotherapy in patients with epilepsy associated with benign epileptiform discharges of childhood (BEDC). Materials and methods. We examined 29 pediatric patients with idiopathic and symptomatic BEDC-associated epilepsy, including continuous spike-and-wave epileptiform activity during slow-wave sleep (CSWS) in the stage of clinical remission. Of those, 12 children received antiepileptic treatment with valproic acid, and 17 children received levetiracetam. The examination included passive awake EEG recordings (with functional tests) as well as daytime sleep EEG recordings (within 60 minutes). Results. Levetiracetam was no less efficient in monotherapy of BEDC-associated epilepsy (including the CSWS patterns) than the traditionally used valproic acid, especially in idiopathic forms of epilepsy. Conclusion. Levetiracetam can be recommended for the first-choice basic anti-epileptic monotherapy treatment.

About the Authors

N. A. Borovkova
Children’s Clinical Hospital named after P. I. Pichugin
Russian Federation

MD, Neurologist, Department of Neurology

43 Komsomolsky Prospect, Perm 614039, Perm region, Russia

A. G. Malov
Vagner Perm State Medical University
Russian Federation

MD, PhD, Neurologist, Associate Professor at the Pervushin Department of Neurology

26 Petropavlovskaya Str., Perm 614990, Perm region, Russia


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For citation:

Borovkova N.A., Malov A.G. Efficacy of levetiracetam monotherapy in epilepsy associated with benign epileptiform discharges of childhood. Epilepsy and paroxysmal conditions. 2019;11(1):63-68. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)