Efficacy of levetiracetam monotherapy in epilepsy associated with benign epileptiform discharges of childhood
https://doi.org/10.17749/2077-8333.2019.11.1.63-68
Abstract
Aim. To analyze efficacy of levetiracetam monotherapy in patients with epilepsy associated with benign epileptiform discharges of childhood (BEDC). Materials and methods. We examined 29 pediatric patients with idiopathic and symptomatic BEDC-associated epilepsy, including continuous spike-and-wave epileptiform activity during slow-wave sleep (CSWS) in the stage of clinical remission. Of those, 12 children received antiepileptic treatment with valproic acid, and 17 children received levetiracetam. The examination included passive awake EEG recordings (with functional tests) as well as daytime sleep EEG recordings (within 60 minutes). Results. Levetiracetam was no less efficient in monotherapy of BEDC-associated epilepsy (including the CSWS patterns) than the traditionally used valproic acid, especially in idiopathic forms of epilepsy. Conclusion. Levetiracetam can be recommended for the first-choice basic anti-epileptic monotherapy treatment.
About the Authors
N. A. BorovkovaRussian Federation
MD, Neurologist, Department of Neurology
43 Komsomolsky Prospect, Perm 614039, Perm region, Russia
A. G. Malov
Russian Federation
MD, PhD, Neurologist, Associate Professor at the Pervushin Department of Neurology
26 Petropavlovskaya Str., Perm 614990, Perm region, Russia
References
1. Fejerman N., Caraballo R. Definition of syndromes, seizure types and nosologic spectrum. In: Fejerman N, Caraballo R. eds. Benign focal epilepsies in infancy, childhood and adolescence. France: John Libbey; 2007: 3-15.
2. Zenkov L. R. Neuropathology of epileptic encephalopathies and non-paroxysmal epileptic disorders and principles of their treatment. Neurology, Neuropsychiatry, Psychosomatics. 2010; 2 (2): 26-32. (In Russ.). https://doi.org/10.14412/2074-2711-2010-80.
3. Panayiotopoulos C. P. Benign childhood focal seizures and related epileptic syndromes In: Panayiotopoulos CP. The Epilepsies: Seizures, Syndromes and Management. 2005: 223-269.
4. Doose H., Baier W. K. Benign partial epilepsy and related conditions: Multifactorial pathogenesis with hereditary impairment of brain maturation. European Journal of Pediatrics. 1989; 149: 152-58.
5. Instructions for medical use of the drug levetiracetam. State register of medicines. [Electronic resource] URL: https://grls.rosminzdrav.ru/Default.aspx. Accessed: 12.26.2018.
6. Mukhin K. Y., Glukhova L. Y., Makievskaya E. R. Epilepsy with electrical status epilepticus during slow-wave sleep with a focus on electroencephalographic criteria. Russian Journal of Child Neurology. 2017; 12 (1): 21-35. (In Russ.) https://doi.org/10.17650/2073-8803-2017-12-1-21-35.
7. Kramer U., Sagi L., Goldberg-Stern, Zelnik N., Nissenkorn A., Ben-Zeev B. Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). Epilepsia. 2009; 50 (6): 1517-24.
8. Ermolaenko N. A., Buchneva I. A., Zakharova E. I. The Clinical and Neurophysiological Features of Epileptic Syndromes Associated with Benign Focal Epileptiform Discharges of Childhood. Neurology, Neuropsychiatry, Psychosomatics. 2014; 6 (1S): 9-12. (In Russ.) https://doi.org/10.14412/2074-2711-2014-1S-9-12
9. Kholin A. A., Zavadenko N. N., Fedonyuk I. D., Il`ina E.S. Efficacy and safety of levetiracetam in children with electrical status epilepticus during slow-wave sleep (ESES). Epilepsia and Paroxysmal conditions. 2017; 9 (2): 21-28. (In Russ.) https://doi.org/10.17749/2077-8333.2017.9.2.021-028.
Review
For citations:
Borovkova N.A., Malov A.G. Efficacy of levetiracetam monotherapy in epilepsy associated with benign epileptiform discharges of childhood. Epilepsy and paroxysmal conditions. 2019;11(1):63-68. (In Russ.) https://doi.org/10.17749/2077-8333.2019.11.1.63-68
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