Факторы эволюции генетических генерализованных эпилепсий
https://doi.org/10.17749/2077-8333.2019.11.2.187-194
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Аннотация
В статье проанализированы литературные данные, касающиеся клиники, генетических детерминант, прогноза и эволюции генетических генерализованных эпилепсий и характерных для них электроэнцефалографических коррелятов с целью определения негативных прогностических факторов. Приведены результаты исследований детской абсансной эпилепсии, юношеской миоклонической эпилепсии и эпилепсии с изолированными генерализованными тонико-клоническими приступами. Выявлены факторы, способствующие как более тяжелому течению и исходам данных форм заболевания, так и указывающие на ожидаемо более благоприятное развитие: такие как возраст дебюта, вид инициальной терапии, сроки до начала инициальной терапии и сроки до ответа на нее, когнитивный статус, комбинация приступов, патологические изменения электроэнцефалограммы, наличие неврологического дефицита. Проведенный анализ показал, что к факторам, достоверно ухудшающим прогноз, относятся наличие более одного типа приступов, отсроченный ответ на стартовую терапию, политерапия и сопутствующие когнитивные нарушения.
Об авторах
Е. А. Морозова
Казанская государственная медицинская академия - филиал федерального государственного бюджетного образовательного учреждения дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации
Россия
Россия
Морозова Елена Александровна - доктор медицинских наук, профессор кафедры детской неврологии.
Ул. Муштари, д. 11, Казань 420061
Ф. И. Гусяков
Государственное автономное учреждение здравоохранения Детская городская больница № 8
Россия
Россия
Гусяков Филипп Игоревич - врач-невролог ГАУЗ «Детская городская больница №8» Казани.
Ул. Галеева, д. 11, Казань 420061
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Рецензия
Для цитирования:
Морозова Е.А., Гусяков Ф.И. Факторы эволюции генетических генерализованных эпилепсий. Эпилепсия и пароксизмальные состояния. 2019;11(2):187-194. https://doi.org/10.17749/2077-8333.2019.11.2.187-194
For citation:
Morozova E.A., Gusyakov F.I. Evolution of genetically determined generalized epilepsies. Epilepsy and paroxysmal conditions. 2019;11(2):187-194. (In Russ.) https://doi.org/10.17749/2077-8333.2019.11.2.187-194
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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)
ISSN 2311-4088 (Online)
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