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Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole

https://doi.org/10.17749/2077-8333.2019.11.4.357-363

Full Text:

Abstract

Aim – experimental evaluation of the antiepileptic activity of a new amide derivative of valproic acid and 1,3,4-thiadiazole.

Materials and Methods: The antiepileptic activity of valprazolamide (N- (5-ethyl-1,3,4-thiadiazol-2-yl) -2-propylpentanamide) was tested in mice using the model of maximal electroshock and also the antagonism model with pentylenetetrazole. Neurotoxicity was assessed with the rotating rod test and the probit analysis. The therapeutic and protective index and the ED50 values were calculated for each experimental model of epilepsy.

Results: The ED50 values of valprazolamide (intraperitoneally) in mice with seizures induced by pentylenetetrazole or maximal electroshock were 74.5 (46.8-106.4) mg/kg or 138.4 (97.2-197.2) mg/kg, respectively.

Conclusion: The new amide derivative of valproic acid and 1,3,4-thiadiazole (valprazolamide) has an antiepileptic activity.

The author declares no financial support or conflict of interest with respect to this publication.

About the Author

A. S. Malygin
Tver State Medical University
Russian Federation
Alexander S. Malygin – MD, Resident-in-Training, Department of Pharmacology & Clinical Pharmacology


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For citation:


Malygin A.S. Study on the antiepyleptic activity of the new amide derivative of valproic acid and 1,3,4-thiadiazole. Epilepsy and paroxysmal conditions. 2019;11(4):357-363. (In Russ.) https://doi.org/10.17749/2077-8333.2019.11.4.357-363

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)