The effect of anxiety on the parameters of carpal tapping in patients with post-stroke epilepsy

Aim. To study the characteristics of carpal tapping in the normal condition and the effect of subclinical anxiety on its parameters with post-stroke epilepsy in adults.

Material and methods. We examined 140 people aged from 22 to 55 years. The total sample was divided into 3 observation groups: the first (I) group included healthy volunteers; the second (II) group included the patients with post-stroke frontal lobe epilepsy; the third (III) group included the patients with post-stroke temporal lobe epilepsy. Each group was divided into two subgroups: subgroup Ia (33 people) included healthy volunteers who did not show reliably expressed symptoms of anxiety; subgroup Ib (27 people) included healthy volunteers with subclinical anxiety; subgroup IIa (20 people) included patients with post-stroke frontal lobe epilepsy who did not show reliably expressed symptoms of anxiety; subgroup IIb (20 people) included patients with post-stroke frontal lobe epilepsy with subclinical anxiety; subgroup IIIa (19 people) included patients with post-stroke temporal lobe epilepsy who did not show reliably expressed symptoms of anxiety; subgroup IIIb (21 people) included patients with post-stroke temporal lobe epilepsy with subclinical anxiety. The parameters of carpal tapping were investigated using the modified author’s program “Method of influencing an individual human rhythm through exogenous rhythmic stimulation”.

Results. An acceleration of the individual rhythm was found in the presence of subclinically expressed anxiety both in healthy volunteers (from 1.13 Hz to 1.53 Hz) and in patients with post-stroke frontal lobe and temporal lobe epilepsy (from 2.07 Hz to 3, 45 Hz and from 1.83 Hz to 2.82 Hz, respectively). The rate of acceleration of the individual rhythm in patients with post-stroke frontal lobe and temporal lobe epilepsies was higher than in healthy volunteers (1.66 and 1.54 versus 1.35, respectively).

Conclusion. The effect of anxiety on the parameters of carpal tapping was greater in patients with post-stroke epilepsy compared with healthy volunteers.

1. Nasyrov R. F., Sivakova N. A., Lipatova L. V., Ivashchenko D. V., Sosina K. A., Drokov A. P., Schneider N. A. Biological markers, efficacy and safety of antiepileptic drugs: pharmacogenetics and pharmacokinetics. Siberian Medical Review. 2017; (1): 17–25. DOI: 10.20333 / 2500136-2017-1-17-25

2. Kalinin V. V. Correction of affective and cognitive impairments in patients with epilepsy and the importance of lamotrigine. Neurology, neuropsychiatry, psychosomatics. 2013; 2: 78–83.

3. Dmitrenko D. V., Schneider N. A., Strotskaya I. G., Kichkaylo A. S., Zobova S. N. Mechanisms of valproate-induced teratogenesis. Neurology, neuropsychiatry, psychosomatics. 2017; 9 (1S): 89–96. DOI: 10.14412 / 2074-2711-2017-1S-89-96. [in Russian]

4. Avakyan G. N. Modern epileptology. Problems and solutions. Epilepsia i paroksizmal'nye sostoania / Epilepsy and Paroxysmal Conditions 2014; 6 (4): 46–49. [in Russian]

5. Lebedeva A. V., Melikyan E. G., Hecht A. B. Therapy of depression in patients with focal epilepsy (experience with citalopram). Neurology, neuropsychiatry, psychosomatics. 2011; 2: 50–56. [in Russian]

6. Usyukina U., Kornilov S., Lavrushchik M. Clinical and psychopathological features of organic personality disorder due to epilepsy. Review of Psychiatry and Medical Psychology Bekhtereva. 2018; (1): 49–55. [in Russian]

7. Moskaleva P. V., Shnayder N. A., Neznanov N. G., Dmitrenko D. V., Golokov V. A., Nasyrova R. F. Exogenous melatonin as a disease-modifying therapy for epilepsy. Epilepsia i paroksizmal'nye sostoania / Epilepsy and Paroxysmal Conditions. 2019;11(2):124–141. [in Russian] DOI: https://doi.org/10.17749/2077-8333.2019.11.2.124-141.

8. Loscher W. Current status and future directions in the pharmacotherapy of epilepsy. Trends Pharmacol Sci. 2002; 23 (3): 113–118. 9. Sterman M. B., Egner T. Foundation and practice of neurofeedback for the treatment of epilepsy. Appl. Psychophysiol. Biofeedback. 2006; 31(1): 21–35.

9. Narodova E. A., Shnayder N. A., Narodova V. V., Dmitrenko D. V., Artyukhov I. P. The role of non-drug treatment methods in the management of epilepsy. International Journal of Biomedicine. 2018; 8(1): 9–14. DOI: 10.21103/Article8(1)_BR

10. Kryzhanovsky G. N. Basics of general pathophysiology: Health. Medical Sciences – General Pathology – A Handbook for Specialists. Moscow. 2011; 252. [in Russian]

11. Markina L. B. Features options poststroke depression, predictors and risks of its developmeny. Bulletin SMUS74. 2017; 1(16): 31–34. [in Russian]

12. Snaith R. P., Zigmond A. S. The hospital anxiety and depression scale. Br Med J (Clin Res Ed). 1986; 292(6516): 344.

13. Narodova E. A., Rudnev V. A., Shnayder N. A., Narodova V. V., Erakhtin E. E., Dmitrenko D. V., Shilkina O. S., Moskaleva P. V., Gazenkampf K. A. Parameters of the wrist tapping using a modification of the original method (Method of exogenous rhythmic stimulation influence on an individual human rhythm). International Journal of Biomedicine. 2018; 8(2): 155–158. DOI: 10.21103/Article8(2)_OA10.

14. Narodova E. A., Prokopenko S. V., Narodova V. V., Narodov A. A. Investigation of internal speech by registering microarticulation of tongth in helthy people. Bulletin of new medical technologies. 2012; 4: 73-75. [in Russian]

15. Efimova V. L., Neiman M. A. Work with the rhythm in the system of pedagogical support of children with learning difficulties. Global scientific potential. 2015; 5: 10–16.