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COMPARATIVE EVALUATION OF THE EFFICACY AND SAFETY OF VALPROIC ACID DERIVATIVES

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Abstract

Abstract: this article discusses the comparative efficacy and safety of valproic acid derivatives (various salts), and the original of generic drugs based on it, are the literature data and the results of our experimental and clinical studies on the interchangeability of original and generic drugs – valproic acid derivatives, in particular Depakin Chrono, Convulex Retard, Valparin XP and Enkorat Chrono. The results of the research, conclusions were drawn, which essentially boils down to if inability to provide original drugs, a transition to generic valproic acid, in particular Enkorat Chrono, is possible.

About the Authors

O. L. Badalyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation


S. G. Burd
Pirogov Russian National Research Medical University, Moscow
Russian Federation


A. A. Savenkov
Pirogov Russian National Research Medical University, Moscow
Russian Federation


G. G. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation


E. V. Yutskova
Pirogov Russian National Research Medical University, Moscow
Russian Federation


G. N. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation


References

1. Avakjan G.N., Belousova E.D., Ermakov A.Ju., Avakjan G.G. Jepilepsija i paroksizmal’nye sostojanija. 2013; 3: 41-48.

2. Avakjan G.G., Nerobkova L.N., Olejnikova O.M., Voronina T.A., Avakjan G.N., Gusev E.I. Jepilepsija i paroksizmal’nye sostojanija. 2011; 2: 34-44.

3. Avakjan G.N., Olejnikova O.M., Hromyh E.A., Badaljan O.L., Lagutin Ju.V. Jepilepsija i paroksizmal’nye sostojanija. 2009; 1: 31-38.

4. Avakjan G.G., Nerobkova L.N., Olejnikova O.M., Voronina T.A., Avakjan G.N., Gusev E.I. Jepilepsija i paroksizmal’nye sostojanija. 2011; 2: 34-44.

5. Artemova I.Ju., Badaljan O.L., Bogomazova M.A., Zhuravleva I.I., Ismailov A.M., Komel’kova E.G., Lesinker L.N., Logvinov Ju.I., Otcheskaja O.V., Petrov S.V., Solomatin Ju.V., Teplysheva A.M., Vdovichenko T.N., Hromyh E.A., Chukanova A.S., Lebedeva A.V., Burd S.G., Bojko A.N. Jepilepsija i paroksizmal’nye sostojanija. 2013; 1: 6-10.

6. Belousova E.D., Avakjan G.N. Jepilepsija i paroksizmal’nye sostojanija. 2012; 2: 48-54.

7. Burd S.G., Lebedeva A.V., Artemova I.Ju., Badaljan O.L., Bogomazova M.A., Zhuravleva I.I., Ismailov A.M., Komel’kova E.G., Lesinker L.N., Logvinov Ju.I., Otcheskaja O.V., Petrov S.V., Solomatin Ju.V., Teplysheva A.M., Vdovichenko T.N., Hromyh E.A., Chukanova A.S., Bojko A.N. Jepilepsija i paroksizmal’nye sostojanija. 2012; 2: 56-66.

8. Vlasov P.N., Petruhin A.S., Naumova G.I. Kachestvennaja klinicheskaja praktika. 2005; 3: 1-9.

9. Gromov S.A. i dr. Nejropsihotropnye preparaty. Moscow. 1995; 69-72.

10. Zenkov L.R. Rus. med. zhurnal. 2000; 8: 15-16.

11. Karlov V.A. Vrach. 1993; 8: 26-27.

12. Maksutova A.L. Rogacheva T.A., Zheleznova E.V. Mesto antikonvul’santov retardirovannogo dejstvija v lechenii bol’nyh jepilepsiej s psihicheskimi narushenijami. Materialy Rossijskoj nauchno-prakticheskoj konferencii: Sovremennye metody diagnostiki i lechenija jepilepsii. (A place anticonvulsants retardirovannogo action in the treatment of epileptic patients with mental disorders. Proceedings of Russian scientific-practical conference: Modern methods of diagnosis and treatment of epilepsy). Smolensk. 1997; 54-55.

13. Maksutova A.L., Rogacheva T.A., Zheleznova E.V., Sokolova L.V. Ob’emy primenenija otdel’nyh antikonvul’santov v specializirovannom jepileptologicheskom stacionare: materialy 13-go S’ezda psihiatrov Rossii (Volumes application of certain anti¬convulsants in epilepsy specialist hospital: Proceedings of the 13th Congress of Russian psychiatrists). Moscow. 2000; 185 s.

14. Petruhin A.S., Muhin K.Ju. Zh. Nevrol. i Psihiatr. 2001; 101 (6): 20-27.

15. Rogacheva T.A. Mesto konvul’sofina v lechenii bol’nyh jepilepsiej. Materialy 4-go S’ezda nevrologov Rossii (Konvulsofina place in the treatment of patients with epilepsy. Proceedings of the 4th Congress of neurologists Russia). Kazan. 2001; 271 s.

16. Rogacheva T.A. Zakonomernosti stanovlenija i techenija remissii pri jepilepsii. Dissertacija na soiskanie uchenoj stepeni doktora medicinskih nauk. Doct, Diss. (Regularities of formation and flow of remission of epilepsy. Dr. diss). Moscow. 2006.

17. Sokolov A.V., Belousov Ju.B., Tishhenkova I.F. Zh. O rynke lekarstv i medicinskoj tehniki. M. 2006; 4 (6): 11 s.

18. Shan’ko G.G., Ivashina E.N., Charuhina N.M. Sravnitel’naja ocenka jeffektivnosti razlichnyh val’proatov pri jepilepsii u detej (Comparative evaluation of the effectiveness of various valproate for epilepsy in children). Minsk. 2003; 6 s.

19. Browne T., Holmes G. Epilepsy. 2006; 381: p. 13.

20. Janz D., Christe W. Generalized epilepsies. New York. 1992; 14: 145-162.

21. Nikolson A., Appleton R.E., Chadwick D.W., Smith D.F. The relationship between treatment with valproate, lamotrigine and topiramate and the prognosi of the idiopathic generalized epilepsies. J. Neurolog. Neurosurg. Psychiatry. 2004; 75: 75-79.

22. Jedrzejczak J. et al. An observational study of first-line valproate monotherapy in focal epilepsy. Eur. J. Neurol. 2008; 15 (1): 66-72.

23. Besag F.M.S., Panayiotopoulos C., Chivers et al Therapeeutic interaction of lamotrigine with valproate and suximides. Epilepsia. 1995; 36 (l): 116.

24. Bowden C.L. New concept in mood stabilization: evidence for the effectiveness of valproate and lamotrogine. Neuropscho¬pharmacology. 1998; 19: 194-199.

25. Biopharm Drug Disposition. 1996; 17: 175-182.

26. Bourgeois B.F.D. Valproic acid – clinical use. In Antiepileptic Drugs, Fourth Edition. Eds: R.H. Levy, R.H. Mattson. New York. 1995.

27. Brodie M.J, Yen A.W. 105 Study Group. Lamotrigine substitution study: evidence for synergism with sodium valproate? Epilepsy Res. 1997; 26: 423-432.

28. Brouwer O.F., Pieters N.S., Eddelbroek P.M. et al. Conventional and controlled-realesed valproat in children wuth epilepsy: a crossover study comparing plasma levels and cognitive performance. Epilepsy Res. 1992; 13: 245-253.

29. Epilepsia 1994; 35 (l): 99-100.

30. Janz D., Christine W. Generalized epilepsies. In: Resor S.R, Kutt H. et al. The medical treatment of epilepsy. New York. 1992; 145-62.

31. Lennkh C., Simhandi C. Current aspects of valproat in bipolar disorder. Int. Clin. Psychopharmacol. 2000; 15: 1-11.

32. Nikolson A., Appleton R.E., Chadwick D.W., Smith D.F. The relationship between treatment with valproate, lamotrigine, topiramate and the prognosis of the idiopathic generalized epilepsies. J. Neurology Neurosurg. Psychiatry. 2004; 75: 75-79.

33. Royer-Morrott M.J., Zhiri A., Jacob F. et al. Influence of food intake on pharmacokinetics of sustained realease formulation of sodium valproate. Biopharm. Drug Disposition. 1993; 14: 511-518.

34. Shorvon et al. Clinical Epilepsy. 2004; Indian edn: 219.


For citation:


Badalyan O.L., Burd S.G., Savenkov A.A., Avakyan G.G., Yutskova E.V., Avakyan G.N. COMPARATIVE EVALUATION OF THE EFFICACY AND SAFETY OF VALPROIC ACID DERIVATIVES. Epilepsy and paroxysmal conditions. 2014;6(2):39-44. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)