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Epileptiform activity index for assessing oxcarbazepin therapy of newly-diagnosed focal epilepsy in adolescents and adults

https://doi.org/10.17749/2077-8333/epi.par.con.2020.035

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Abstract

Introduction. Oxcarbazepine (OXC) is approved for initial and adjunctive therapy of focal epilepsy (FE), being also a drug of choice in case of pediatric FE. Despite that OXC has been used in the Russian Federation (RF) since 2007, studies assessing its efficacy and tolerability are scarce.

Aim. To evaluate efficacy and tolerability of OXC therapy in patients with newly-diagnosed epilepsy.

Patients and methods. There were enrolled 103 patients (56 (54.4%) into the study: males and 47 (45.6%) females with FE, aged 44.32±19.71 years. Depending on the OXC daily dose, all patients were divided into 3 subgroups: <1200 mg/ day (n=20; 19.4%); 1200 mg/day (n=67; 65.1%), and > 1200 mg/day (n=16; 15.5%). Video-electroencephalographic (video-EEG) monitoring was performed at each visit (at baseline, 1, 3, 6 and 12 months after then onset of therapy). Treatment efficacy was assessed by using the criteria of retention on treatment, seizure absence, seizure rate decrease by >50%, seizure rate decrease by <50% (insufficient efficacy). Adverse effects (AEs) were assessed in accordance to the Side Effects of Anti-Epileptic Drugs (SIDAED) treatment scale and emerging pharmacodynamics aggravation (increased seizure rate compared to baseline/emergence of new seizure type).

Results. It was found that retention on OXC monotherapy during the 12-month follow-up period was achieved in 69.0% (n=71) patients, among which 15.5% (n=16) received less than OXC at dose of 1200 mg/day, 44.7% (n=46) - 1200 mg/ day, and 8.8% (n=9) - more than 1200 mg/day, respectively. Total rate of intolerable AEs during the follow-up period was 13.6% (n=14). Comparing initial vs. 12-month timepoint EAI magnitude after the onset of OXC therapy revealed that it was significantly decreased by 6.9-fold (p<0.05).

Conclusions. OXC is an effective drug for the initial treatment of FE in adolescents and adults highlighted with favorable tolerability profile. 12-month follow-up monitoring demonstrated that EAI was reduced almost by 7-fold allowing to consider it as an objective quantitative marker for assessing treatment efficacy.

About the Authors

V. A. Karlov
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Vladimir A. Karlov - Honored Scientist of the Russian Federation, Associate Member of the Russian Academy of Sciences, MD, Dr Sci Med; Professor of Chair of Neurology, Department of General Medicine, Evdokimov Moscow State University of Medicine and Dentistry; President of the Russian League Against Epilepsy (RLAE) - ILAE Russian Chapter, Scopus ID: 7103065003; RSCI SPIN-code: 2726-9790.

20-1 Delegatskaya Str., Moscow 127473




A. B. Kozhokaru
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation

Angela B. Kozhokaru - MD, PhD, head of the laboratory of clinical neurophysiology, SRC- Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Associate Professor, Department of Neurology, Central SMA of the Presidential administration of the Russian Federation, Scopus ID: 28367717700; RSCI SPIN-code: 1019434.

Zhivopisnaya Str., 46, Moscow 123182




P. N. Vlasov
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Pavel N. Vlasov - MD, Dr Sci Med, Professor, Department of Nervous Diseases, Faculty of Medicine, Scopus ID: 7101688064; RSCI SPIN-code: 701071.

20-1 Delegatskaya Str., Moscow 127473




T. N. Pushkar
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation

Tatyana N. Pushkar- Postgraduate student, Department of Nervous Diseases, Faculty of Medicine, Scopus ID: 57214242006; RSCI SPIN-code: 4413-1310.

Zhivopisnaya Str., 46, Moscow 123182




A. S. Orlova
Sechenov University
Russian Federation

Alexandra S. Orlova - MD, PhD, Associate Professor of the Department of Human Pathology, Scopus ID: 57191331064; RSCI SPIN-code: 684264.

8-2 Trubetskaya Str., Moscow 119048




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For citation:


Karlov V.A., Kozhokaru A.B., Vlasov P.N., Pushkar T.N., Orlova A.S. Epileptiform activity index for assessing oxcarbazepin therapy of newly-diagnosed focal epilepsy in adolescents and adults. Epilepsy and paroxysmal conditions. 2020;12(3):137-146. (In Russ.) https://doi.org/10.17749/2077-8333/epi.par.con.2020.035

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