ATYPICAL EVOLUTION OF BENIGN CHILDHOOD EPILEPSY WITH CENTRAL TEMPORAL SPIKES AS A MANIFESTATION OF EPILEPTIC ENCEPHALOPATHY
Abstract
Abstract: the article considers options of atypical course and atypical evolution of benign childhood epilepsy with central temporal spikes. Probable mechanism and scheme of development of benign focal epileptiform discharges of childhood on an EEG, their relation to epileptic seizures, as well as mechanism of development of secondary bilateral synchronization and electrical status epilepticus during slow-wave sleep phase is described in the article. The authors suggest a key mechanism in development of atypical evolution through formation of reciprocal self-sustaining epileptic thalamo-cortico-thalamic closed circles, which pathogenesis is based on self-induction and recirculation of epileptiform activity by «re-entry» mechanism. The article presents a clinical example of atypical evolution of rolandic epilepsy into acquired epileptiform opercular syndrome. The authors describe basic principles and approaches to the treatment of syndromes with benign focal epileptiform discharges of childhood and ways of prevention of atypical evolution.
About the Authors
D. A. Kot
City Clinical child psychiatric clinic, Minsk
Belarus
Belarus
L. V. Shalkevich
Belarusian medical academy of postgraduate education, Minsk
Belarus
Belarus
References
1. Kot D.A. Nevrologija i nejrohirurgija. Vostochnaja Evropa . 2012; 4 (16): 106-108.
2. Kovtun O.P., Korjakina O.V., Lvova O.A., Ovsova O.V., Nevmerzhickaja K.S. Seizures in infants and pediatric practice in pediatric neurologist: Textbook [Sudorogi u detej rannego vozrasta v praktike pediatra i detskogo nevrologa: uchebno-metodicheskoe posobie]. Ekaterinburg.2012; 54 s.
3. Lvova O.A., Sulimov A.V., Korjakina O.V.,Panjukova I.V. Nejrohirurgija i nevrologija detskogo vozrasta . 2009; 3-4: 41-44.
4. Holin A.A., Fedonjuk I.D., Kolpakchi L.M.,Ilina E.S., Muhin K.Ju. Russkij zhurnal detskoj nevrologii . 2013; 4. 2014; 1: 5-22.
5. Shalkevich L.V., Kot D.A. ARS MEDICA. 2013; 7: 119-128.
6. Shalkevich L.V., Kot D.A. Epileptic encephalopathy in infancy: a teaching aid [ Jepilepticheskie jencefalopatii rannego detskogo vozrasta: uchebno-metodicheskoe posobie]. Minsk. 2013; 48 s.
7. Shalkevich L.V., Kot D.A. Medicinskie novosti. 2008; 14: 45-48.
8. Aicardi J., Chevrie J.J. Atypical benign partial epilepsy of childhood. Dev. Med. Child. Neurol . 1982; 24: 281-292.
9. Avanzini G. et al. The system epilepsies: A pathophysiological hypothesis. Epilepsia. 2012; 53 (5): 771-778.
10. Datta A., Sinclair D.B. Benign epilepsy of childhood with rolandic spikes: typical and atypical variants. Pediatr. Neurol . 2007; 36: 141-145.
11. Deonna T., Zesiger P., Davidoff V., Maeder M., Mayor C., Roulet E. Benign partial epilepsy of childhood: a longitudinal neuropsychological and EEG study of cognitive function. Dev. Med. Child. Neurol. 2000; 42: 595-603.
12. Doose H. EEG in Childhood Epilepsy: Initial Presentation & Long-Term Follow-Up. London. 2003; 72-80.
13. Fejerman N Caraballo R Dalla Bernardina B. Atypical evolutions of benign focal epilepsies in childhood. In: Fejerman N., Caraballo R.H. (Eds). Benign focal epilepsies in infancy, childhood and adolescence. Montrouge. 2007; 179-220.
14. Fejerman N., Caraballo R., Tenembaum S. Atypical evolutions of benign localization-related epilepsies in children: are they predictable? Epilepsia. 2000; 4:380-390.
15. Fejerman N., Caraballo R. et al. Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES). Epilepsia. 2012; 53 (7): 1156-1161.
16. Fejerman N. Atypical evolutions of benign partial epilepsies in children. Int. Pediatr. 1996; 11: 351-356.
17. Fejerman N. Benign childhood epilepsy with centrotemporal spikes. In Engel J., Pedley T.A. (Eds). Epilepsy. A Comprehensive Textbook. 2nd ed. Philadelphia. 2008; 2369-2378.
18. Fejerman N. Atypical rolandic epilepsy. Epilepsia. 2009; 50 (7): 9-12.
19. Gobbi G., Boni A., Filippini M. The spectrum of idiopathic roland ic epilepsy syndromes and idiopathic occipita l epilepsies: from the benign to the disabling. Epilepsia. 2006; 47 (2): 62-66.
20. Huguenard John R. Circuit Mechanisms of Spike-Wave Discharge: Are There Similar Underpinnings for Centrotemporal Spikes? Epilepsia. 2000; 41 (8): 1076-107
21. Luders H., Noachtar S. eds. Atlas and Classification of Electroencephalography. Philadelphia. 2000.
22. Massa R., De Saint-Martin A., Carcangiu R., Rudolf G., Seegmuller C., Kleitz C., Metz-Lutz M., Hirsch E., Marescaux C. EEG criteria predictive of complicated evolution in idiopathic Rolandic epilepsy. Neurology. 2001; 57: 1071-1079.
23. Piccinelli P., Borgatti R., Aldini A., Bindelli D., Ferri M., Perna S., Pitillo G., Termine C., Zambonin F., Balottin U. Academic performance in children with Rolandic epilepsy. Dev. Med. Child. Neurol. 2008; 50: 353356.
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For citations:
Kot D.A., Shalkevich L.V. ATYPICAL EVOLUTION OF BENIGN CHILDHOOD EPILEPSY WITH CENTRAL TEMPORAL SPIKES AS A MANIFESTATION OF EPILEPTIC ENCEPHALOPATHY. Epilepsy and paroxysmal conditions. 2014;6(2):45-51. (In Russ.)
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