Epilepsy and paroxysmal conditions

Advanced search


Full Text:


Abstract: the article considers historical aspects of formation and development of epileptology in the XX century. it provides interesting facts about directions of development of English, German, French schools of epilepsy. The contribution of parallel developing schools of epilepsy in the U.S. and Canada is highlighted. The article describes formation of domestic epileptology associated in the XIX century with the names of A.Ya. Kozhevnikov and V.M. Bechterev, and, in the XX century, with the names of outstanding Soviet scientists and organizers- D.G. Schaefer, P.M. Sarajishvili, Y.N. Savchenko, Y.i. Belyaev.Successful educational programs under the auspices of Ye.I.Gusev and A.B. Gecht are also outlined in the article.An important aspect of modern epileptology is the integration with other therapeutic areas and directions, such as obstetrics and gynecology, surgery, neurogenetics etc. The article describes the new direction in epileptology - study of "epilepsy without seizures" or epileptic encephalopathy version without seizure. Particular attention is paid to problems, solutions of which are necessary for further development of Russian epileptology.

About the Author

V. A. Karlov
I.M. Sechenov First Moscow State Medical University
Russian Federation


1. Aksenova M.G., Burd S.G., Kachalin E.Ju. i dr. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2007; 107 (1): 42-46.

2. Behterev V.M. Epilepsy. Proceedings of the Third Congress of Russian psychiatrists. [Jepilepsija. Trudy tretego sezda otechestvennyh psihiatrov]. St. Petersburg. 2011.

3. Bocharova E.V., Ilenko L.I., Holodova I.N., Koval G.S., Pylaeva O.A., Voronkova K.A. Vestnik jepileptologii. 2013; 1: 13-21.

4. Vlasov P.N. Jepilepsija u zhenshhin: klinicheskie, jelektrofiziologicheskie, gormonalnye i terapevticheskie aspekty. dokt, Diss. (Epilepsy in women: clinical, electrophysiological, hormonal and therapeutic aspects). Dr. diss. Moscow. 2000.

5. Zenkov L.R. Non-paroxysmal epileptic disorder [Neparoksizmalnye jepilepticheskie rasstrojstva]. Moscow. 2007.

6. Zheleznova E.V. Jepilepsija s nejrojendokrinnymi i psihicheskimi rasstrojstvami u zhenshhin (klinika, terapija). dokt, Diss. (Epilepsy with neuroendocrine and psychiatric disorders in women: clinic, therapy). Dr. diss. Moscow. 2006.

7. Zheleznova U.V., Kalinin V.V. Epilepsy in women (neuroendocrine aspect) [Jepilepsija u zhenshhin (nejrojendokrinnyj aspekt)]. Moscow. 2009.

8. Zhidkova I.A. Vlijanie jepilepsii i antijepilepticheskoj terapii na reproduktivnoe zdorove zhenshhiny. dokt, Diss. (Effect of epilepsy and antiepileptic therapy on womens reproductive health). Dr. diss. Moscow. 2010.

9. Zhidkova I.A., Karlov V.A., Adamjan L.V. Epilepsy and womens reproductive health. Clinical, pathogenetic and therapeutic aspects [Jepilepsija i reproduktivnoe zdorove zhenshhiny. Klinicheskie, patogeneticheskie i terapevticheskie aspekty]. 2012. 288 s.

10. Zhidkova I.A. Vestnik Jepileptologii. 2013 (1): 8-12.

11. Karlov V.A. status epilepticus [Jepilepticheskij status]. Moscow. 1974.

12. Karlov V.A. Convulsive and non-convulsive status epilepticus [Sudorozhnyj i bessudorozhnyj jepilepticheskij status]. Moscow. 2007.

13. Karlov V.A. Epilepsy in children and adult women and men [Jepilepsija u detej i vzroslyh zhenshhin i muzhchin]. Moscow. 2010.

14. Karlov V.A., Dondov B. Transcranial magnetic stimulation in patients with various forms of epilenticheskih seizures. Jubilee collection of scientific papers [Transkranialnaja magnitnaja stimuljacija u bolnyh s razlichnymi formami jepilenticheskih pripadkov. Jubilejnyj sbornik nauchnyh trudov]. Moscow. 2003; 168 s.

15. Karlov V.A., Gnezdickij V.V. Prefrontalnaja kora i jepileptogenez. 3-ja Vostochno-evropejskaja konferencija «Jepilepsija i klinicheskaja nevrologija». (Prefrontal cortex and epileptogenesis. 3rd East European Conference “Epilepsy and Clinical Neuroscience”). Gurzuf. 2000; 19-20.

16. Karlov V.A., Petrenko S.E. Function status orbitofrontal cortex and caudate nucleus in epileptogenesis. Neurophysiological mechanisms of epileptogenesis [Znachenie funkcionalnogo sostojanija orbitofrontalnoj kory i hvostatogo jadra v jepileptogeneze. Nejrofiziologicheskie mehanizmy jepileptogkneza]. Tbilisi. 1980; 221-228.

17. Karlov V.A., Ovnatanov V.S. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 1987; 87 (6): 805-8011.

18. Kozhevnikov A.Ja. Medicinskoe obozrenie. 1994; 43 (4): 97-118.

19. Krikova E.V., Valdman U.A., Avakjan G.N. i dr. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2007; 107 (10): 57-062.

20. Kryzhanovskij G.N. Determinantal structure pathologies of the nervous system [Determinantnye struktury v patologii nervnoj sistemy]. Moscow. 1980.

21. Muhin K.Ju., Petruhin A.S., Holin A.A. Epileptic encephalopathy and similar syndromes in children [Jepilepticheskie jencefalopatii i shozhie sindromy u detej]. Moscow. 2011.

22. Nesterov L.N. Kozhevnikov epilepsy [Kozhevnikovskaja jepilepsija]. Saratov. 2006.

23. Petruhin A.S. Epileptology in childhood [Jepileptologija detskogo vozrasta]. Moscow. 2000.

24. Savickaja O.N., Karlov V.A., Glejzer M.A. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 1980; 6: 841-844.

25. Saradzhishvili P.M., Geladze T.Sh. Epilepsy [Jepilepsija]. Moscow. 1977.

26. Sepp E.K. Epileptic process. Basic pathogenesis of epilepsy and epileptic limping. Nervous Diseases Clinic Proceedings of the 1st Moscow Medical Institute [Jepilepticheskij process. Osnovnye voprosy patogeneza jepilepsii i jepilepticheskogo pripada. Trudy kliniki nervnyh boleznej 1-go Moskovskogo medicinskogo instituta]. 1937: 9-26.

27. Stepanova T.S., Grachjov K.V. Jelektrofiziologija patogeneticheskogo stereotaksisa pri jepilepsii. Materialy konferencii po probleme jepilepsii (Electrophysiology pathogenetic stereotaxis in epilepsy. Materials Conference on Epilepsy). Erevan. 1976; 87-90.

28. Eadie M.J. Cortical epileptogenesis – Hughlings Jackson and his predecessors. Epilepsia. 2007; 48: 2010-2015.

29. Eadie M.J. William Gowers interpretation of epileptogenic mechanism:1880-1906. Epilepsia. 2011; 52:1045-1051.

30. Feindel W., Leblanc R. Epilepsy surgery: historical highlights (1909-2009). Epilepsia. 2009; 50 (3): 131-151.

31. Gastaut H. Lepilepsie photogenique. Rev Prat. 1951; 1: 105-109.

32. Gibbs F.A., Davis H. Changes in the human electroencephalogram associatedv with loss of consciousness. Am. J. Physiol. 1935; 113: 49-50.

33. Gibbs F., Gibbs E. Diagnosis and localizing value of electroencephalographic studies in sleep. Res. Publ. Assoc. Res. Nerv. Vent. Dis. 1947; 26: 366-376.

34. Gowers W.R. Epilepsia and other chronic convulsive disorders. 2nd ed. J&A Churchill, London. 1901.

35. Gowers W.R. A lecture on dendritis and disease. Lancet. 1906; 168: 67-69.

36. Guekht A., Hauser A., Milchakova L. et al. The epidemiology of epilepsy in the Russian Federation. Epilepsy Res. 2010; 92: 209-218.

37. Holmes M.D., Brown M., Tucker D.M. Are generalized seizures truly generalized? Evidens of localized mesial frontal and frontopolar discharges in absences. Epilepsia. 2004; 45:1568-1570.

38. Jackson J.H. A study of convulsions. Trans. St.Andreus Med. Grud Assoc. 1970; 162-204.

39. Karlov V.A. Complex partial status epilepticus. Epilepsia. 2007; 48: 1815.

40. Karlov V.A. Clinico-electrographic variants of absence status epilepticus. The Innsbruck colloquium on status epilepticus. Congress Insbruck. April 2-4 2009; 38.

41. Karlov V.A. Childhood epileptology as the instrument of developing brain investigation. Epilepsia. 2002; 43 (8): 180 p.

42. Karlov V.A., Ovnatanov V.S, Zubakina T.G. Epilepsy with a combination of absence and focal activity on the EEG. Epilepsia 1997; 28: 214.

43. Landau W.N., Kleffner F.R.. Syndrome of acquired epileptic aphasia in children. Neurology. 1957; 7: 523-530.

44. Meencke H.J., Janz D. Neuropathlogical findings in primary generalized epilepsy. Epilepsia. 1984; 25: 8-21.

45. Oguni H. Diagnosis and treatment of epilepsy. Epilepsia. 2004; 45 (8): 13-16.

46. Patry G., Laugubi S., Tassinari C.A. Subclinical electrical status epilepticus induced by sleep in children. Arch Neurol. 1971; 24: 242-252.

47. Penfield W., Flanigin H. Surgical therapy of temporal lobe stizures. Arch. Neurol. Psychiatry. 1950; 64: 491-500.

48. Penfield W., Jasper H. Epilepsy and functional anatomy of the human brain. Boston. 1954.

49. Reynolds E.H. Jackson, Todd, and concept of «discharge» in epilepsy. Epilepsia. 2007; 48: 016-2022.

50. Scholz W., Hager H. Epilepsie. In Lebarsch O., Henke F., Rossle W. (eds). Handbuch der spezielen pathologischen Anatomie und Histologie. Berlin-Gottingen X111/4. 1956; 99-193.

51. Sommer W. Erkrangung des Ammonshorns als atiologischts Moment der Epilepsie. Archiv Psychiatr Nervenkr. 1889; 10: 631-675.

52. Spielmeyer W. Die Pathogenese des Epileptischen Krampfes. Zschr. Neurol. Psychiat. 1927; 109: 501-519.

53. Zifkin B.G., Avanzini G. Clinical neurophysiology with special reference to the electroencephalogram. Epilepsia. 2009; 50 (39): 30-38.


For citations:

Karlov V.A. EPILEPTOLOGY — XX CENTURY. Epilepsy and paroxysmal conditions. 2014;6(2):71-79. (In Russ.)

Views: 713

ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)