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NEUROPHYSIOLOGICAL AND PSYCHOPATHOLOGICAL ASPECTS OF EPILEPSY IN ELDERLY
https://doi.org/10.17749/2077-8333.2016.8.1.029-036
Abstract
In the past decades, an increasing incidence and prevalence of epilepsy in older age groups. Neurophysiological constants of the usual analysis of the EEG in this age group of patients is quite contradictory and inconclusive.
Objective: to determine the most specific EEG-patterns, according to the spectral analysis of coherence and capacity in patients with epilepsy elderly, to identify correlations and neurophysiological data of emotional-affective disorders.
Materials and methods: we Studied 182 patients older, and of these, 142 respectively with the effects of organic lesions of the brain, in 101 patients the disease was complicated by symptomatic epilepsy local. All patients underwent EEG with subsequent processing by the method of coherent analysis. 142 patients with organic and vascular pathology clinical and psychological testing with the use of scales and questionnaires (SF-36,QOLIE-31, SCL-90-R, BDI, HRDS, STAI).
Results: In patients with epilepsy elderly according to the spatial temporal analysis formed persistent «pathological», coherent communication in the Delta and theta bands of the EEG nterhemispheric formation of contacts (T6-P3, T4-T3, P4-O1),
the increase in the number of these links in the rear temporal region, the anterior frontal right, parietal left (T6,T5, F8,P3).
Neurophysiological value analysis confirm the presence of depressive and anxiety disorders in this group of patients (depression in 56,3% of patients with epilepsy, anxiety disorder in 8.7% of MCI — 11.7%. Values of indicators of depression on the BDI scale in amounted 34.81±2.73 points, HRDS — of 21.84±1.50).
Conclusion: the materials obtained during the study allow to make a conclusion about some features of spatial-temporal organization of brain biopotentials in patients with epilepsy elderly in comparison with groups of elderly patients without this pathology, and their mutual relation with the severity of psychopathological symptoms.
About the Authors
V. A. MikhailovRussian Federation
MD, deputy director of innovative scientific development and international cooperation, the head of the international department, chief researcher and scientific director of department of rehabilitation of patients with psychosomatic disorders, St. Petersburg V. M. Bekhterev sychoneurological Research Institute. Address: ul. Bekhtereva, 3, St. Petersburg, Russia, 192019
A. K. Druzhinin
Russian Federation
Junior Researcher at the Department of rehabilitation of patients with psychosomatic disorders, St. Petersburg V. M. Bekhterev Psychoneurological Research Institute. Address: ul. Bekhtereva, 3, St. Petersburg, Russia, 192019
M. Ya. Kissin
Russian Federation
MD, Professor of the Department of Psychiatry and Addiction with the rate of general and medical psychology, psychosomatic medicine psychotherapy basics, St. Petersburg V. M. Bekhterev Psychoneurological Research Institute. Address: ul. Bekhtereva, 3, St. Petersburg, Russia, 192019; head of epilepsy centers of St. Petersburg.
Address: Naberezhnaya Obvodnogo kanala, 13, St. Petersburg, Russia, 192019
A. L. Gorelik
Russian Federation
PhD, head of the department of functional diagnostics, Senior Researcher, St. Petersburg V. M. Bekhterev Psychoneurological Research Institute. Address: ul. Bekhtereva, 3, St. Petersburg, Russia, 192019.
V. V. Bocharov
Russian Federation
PhD, St. Petersburg V. M. Bekhterev. Address: ul. Bekhtereva, 3, St. Petersburg, Russia, 192019; head of the laboratory of clinical psychology and psycho-diagnostics, an assistant professor of psychology and extreme states of crisis psychology department. Address: Naberezhnaya Obvodnogo kanala, 13, St. Petersburg, Russia, 192019
References
1. Avakyan G. N., Badalyan O. L., Burd S. G. Rus. med. zhurn. 2008; 16 (12): 1653-1658.
2. Burd G. S., Gekht A. B., Lebedeva A. V. Zhurn. nevrol. i psikhiatrii. 1998; 2: 4-8.
3. Grindel’ O.M., Koptelov Yu.M., Masherov E. L.i dr. Zhurn. vys. nervn. deyat. 1998; 48 (4): 671-686.
4. Druzhinin A. K., Mikhailov V. A., Lipatova L. V., Kissin M. Ya., Bocharov V. V. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions. 2014; 6 (3): 66-68.
5. Druzhinin A. K., Mikhailov V. A., Lipatova L. V., Kissin M. Ya., Bocharov V. V. Quality of life and affective disorders in patients with epilepsy elderly.
6. Collected materials of All-Russian scientific-practical conference with international participation «An interdisciplinary approach to the understanding and treatment of mental disorders: Myth or Reality (in Russian). Sankt-Peterburg. 14-17 may 2014; 675-677.
7. Zemlyanaya A. A., Kalinin V. V., Kovyazina M. S., Krylov O. E. Zhurn. nevrologii i psikhiatrii im. S. S. Korsakova. 2010; 2: 70-76.
8. Zenkov L. R., Elkin M. N., Medvedev G. A. Clinical Neurophysiology Neuro geriatric disorders. Advances in Neurogeriatrics. Moscow. 1995; 167-173.
9. Kalinin V. V. Brain asymmetry and psychopathology. Neuropsychiatric approach. Functional hemispheric asymmetry. Ed. NN Bogolepova and VF Fokina (in Russian). Moscow. 2004; 594-609.
10. Karlov V. A. Epilepsiya i strukturno-funktsional’naya organizatsiya golovnogo mozga. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova. 2003; 9: 4-8.
11. Kissin M. Ya. Psikhiatriya. 2006; 7: 361-371.
12. Lipatova L. V. Zh. Nevrologii i psikhiatrii im. S. S. Korsakova. 2013; 113 (4): 52-58.
13. Mikhailov V. A., Lipatova L. V. Druzhinin A. K. Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova. 2014; 114 (8): 148-149.
14. Neznanov N. G., Gromov S. A., Mikhailov V. A. Epilepsy, quality of life, treatment (in Russian). SPb. 2005; 294 s.
15. Semenovich A. V. Hemispheric organization of mental processes in left-handers. Hemispheric interaction (in Russian). Moscow. 2009; 400 s.
16. Barry J., Lembke A., Huynh N. Affective disorders in epilepsy. Psychiatric issues in epilepsy. Apractical guide to diagnosis and treatment. Philadelphia. 2001; 45-71.
17. Carlson C. E., St Louis E. D., Granner M. A. Yield of video EEG monitoring in patients over the age of 50. Program and abstract of the American Epilepsy Society 58th Annual Meeting. 3-7 December 2004; Absract 2. 226 p.
18. Cheung C. M., Tsoi T. H., Au-Yeung M., Tang A. S. Epileptic seizures after stroke in Chinese patients. J. Neurol. 2003; 250 (7): 839-843.
19. Hauser A. Epidemiology of newly diagnosed epilepsy. Epilepsia. 2004; 45 (3): 3.
20. Hauser W. A., Kurland L. T. The epidemiology of epilepsy in Rochester. Minnesota. 1935 through 1967. Epilepsia. 1975; 16: 1-66.
21. Jallon P. Electroencephalogram and epilepsy. Europ. Neurol. 1994; 34 (l): l8-23.
22. Kanner A. Depression in neurological disorders. Lundbeck Institute, Cambridge Medical Communication Ltd. 2005; 161 p.
23. La Roche S. M., Helmers S. L. Epilepsy in elderly. Neurologist. 2003; 9: 241-249.
24. Quigg M., Broshek D. K., Heidal-Schiltz S. et al. Depression in intractable partial epilepsy varies by laterality of focus and surgery. Epilepsia. 2003; 44 (3): 419-424.
25. Thatcher R. W., Krause P. J., Hrybyk M. Cortico-cortical association fibers and EEG coherence: A two-compartmental model. Clin.Neurophysiol. 1986; 64 (3): 123-143.
26. Van Cott A. C. Epilepsy and EEG in the Elderly. Epilepsia. 2002; 43 (3): 94-102.
27. Yamada M., Kimura M., Mori T. et al. EEG power and coherence in presenile and senile depression. Characteristic findings related to differences between anxiety type and retardation type. Nippon Ika Daigaku Zasshi. 1995; 62 (2): 176-185.
Supplementary files
For citation: Mikhailov V.A., Druzhinin A.K., Kissin M.Y., Gorelik A.L., Bocharov V.V. NEUROPHYSIOLOGICAL AND PSYCHOPATHOLOGICAL ASPECTS OF EPILEPSY IN ELDERLY. Epilepsia and paroxyzmal conditions. 2016;8(1):29-36. https://doi.org/10.17749/2077-8333.2016.8.1.029-036
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