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Pharmacological predictors of heart rate and conductivity disorders in juvenile myoclonic epilepsy

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Juvenile myoclonic epilepsy (JME) is the most common form of genetic generalized epilepsy. Patients with JME are at risk of life-threatening heart rhythm and conduction disorders as well as sudden death syndrome due to several potential mechanisms: genetic, clinical, neuroanatomical, pharmacological, psychological, comorbid. This lecture reviews important elements of knowledge about the pharmacological predictors of cerebral-cardiac syndrome and sudden unexpected death in epilepsy. The arrhythmogenic potential of antiepileptic drugs most often used in JME (valproic acid, levetiracetam, lamotrigine, topiramate and zonisamide) is considered, none of which can be classified as class A (drug without risk of QT interval prolongation or TdP) regarding a risk of QT interval prolongation and cardiac arrhythmias. Patients with JME require dynamic video-electroencephalographic monitoring and 24-hour electrocardiographic monitoring to reduce a risk of life-threatening cardiac arrhythmias.

About the Authors

N. A. Shnayder
Krasnoyarsk State Medical University; Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation

Natalia A. Shnayder – Dr. Med. Sc., Professor, Leading Researcher, Department of Personalized Psychiatry and Neurology, Bekhterev National Medical Research Centre for Psychiatry and Neurology; Leading Researcher, Center of Collective Usage “Molecular and Cellular Technologies”, Krasnoyarsk State Medical University

WoS ResearcherID: M-7084-2014; RSCI SPIN-code: 1952-304

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

3 Bekhterev Str., Saint Petersburg 192019

M. M. Petrova
Krasnoyarsk State Medical University
Russian Federation

Marina M. Petrova – Dr. Med. Sc., Professor, Chief of Chair of  Outpatient Therapy and General Practice with the Course of Postgraduate Education

Scopus Author ID: 23987271200; WoS ResearcherID: L-5623-2014; RSCI SPIN-code: 5563-1009

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

K. V. Petrov
Krasnoyarsk State Medical University
Russian Federation

Kirill V. Petrov – Resident Physician, Chair of Neurological Diseases with the Course of Postgraduate Education

RSCI SPIN-code: 5830-0594

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

R. F. Nasyrova
Bekhterev National Medical Research Centre for Psychiatry and Neurology
Russian Federation

Regina F. Nasyrova – Dr. Med. Sc., Senior Researcher, Head of the Department of Personalized Psychiatry and Neurology

RSCI SPIN-code: 1952-3043

3 Bekhterev Str., Saint Petersburg 192019


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For citations:

Shnayder N.A., Petrova M.M., Petrov K.V., Nasyrova R.F. Pharmacological predictors of heart rate and conductivity disorders in juvenile myoclonic epilepsy. Epilepsy and paroxysmal conditions. 2021;13(2):168-179. (In Russ.)

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ISSN 2311-4088 (Online)