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Perampanel in the additional therapy of focal and primary generalized tonic-clonic seizures in children 4–12 years old: clinical data, experience of use and practical recommendations

https://doi.org/10.17749/2077-8333/epi.par.con.2021.087

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Abstract

On March 18, 2021, an online council of experts in the field of epilepsy treatment was held, dedicated to the use of perampanel in the additional therapy of focal seizures (FS) and primary generalized tonic-clonic seizures (PGTCS) in children 4–12 years old. During the event, the features of the use of perampanel in this group of patients were discussed, considering the specifics of everyday clinical practice, current possibilities of PGTCS and FS therapy in children, its goals, as well as unsolved problems in the treatment of pediatric patients with PGTCS and FS. Particular attention was paid to the role of perampanel in the treatment of PGTCS and FS in children and its effectiveness in specific types of focal seizures.

About the Authors

K. Yu. Mukhin
St. Luke Institute of Pediatric Neurology and Epilepsy
Russian Federation

Konstantin Yu. Mukhin – Dr. Med. Sc., Professor, Head of Clinic

9 Academician Anokhin Str., Moscow 119571



E. D. Belousova
Pirogov Russian National Research Medical University
Russian Federation

Elena D. Belousova – Dr. Med. Sc., Professor, Head of the Department of Psychoneurology and Epileptology, Research Clinical Institute of Pediatrics

1 Ostrovityanov Str., Moscow 117997



S. G. Burd
Pirogov Russian National Research Medical University
Russian Federation

Sergey G. Burd – Dr. Med. Sc., Professor, Chair of Neurology, Neurosurgery and Medical Genetics

1 Ostrovityanov Str., Moscow 117997



M. V. Barkhatov
Federal Siberian Scientific and Clinical Center, Federal Medical and Biological Agency of Russia
Russian Federation

Mikhail V. Barkhatov – MD, PhD, Director, Center for Epileptology and Pediatric Neurology

26 Kolomenskaya Str., Krasnoyarsk 660037



N. A. Ermolenko
Voronezh Regional Clinical Hospital No. 1
Russian Federation

Natalia A. Ermolenko – Dr. Med. Sc., Head of the Neurological Departmen

151 Moskovskiy Prospect, Voronezh 394068



S. K. Zyryanov
Peoples’ Friendship University of Russia; City Clinical Hospital No. 24
Russian Federation

Sergey K. Zyryanov – Dr. Med. Sc., Professor, Head of Department of General and Clinical Pharmacology, Peoples’ Friendship University of Russia; Deputy Chief Physician for Therapy, City Clinical Hospital No. 24

8 corp. 2 Miklukho-Maklay Str., Moscow 117198

10 Pistsovaya Str., Moscow 127015



E. I. Karpovich
Nizhny Novgorod Semashko Regional Clinical Hospital
Russian Federation

Ekaterina I. Karpovich – Dr. Med. Sc., Head of Neurophysiology Department

190 Rodionov Str., Nizhny Novgorod 603126



E. A. Morozova
Kazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional Education
Russian Federation

Elena A. Morozova – Dr. Med. Sc., Professor, Head of Department of Pediatric Neurology

11 Mushtari Str., Kazan 420012



G. V. Odintsova
Almazov National Medical Research Center
Russian Federation

Galina V. Odintsova – MD, PhD, Head of Research Laboratory of Epileptology

2 Akkuratov Str., Saint Petersburg 197341



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For citation:


Mukhin K.Yu., Belousova E.D., Burd S.G., Barkhatov M.V., Ermolenko N.A., Zyryanov S.K., Karpovich E.I., Morozova E.A., Odintsova G.V. Perampanel in the additional therapy of focal and primary generalized tonic-clonic seizures in children 4–12 years old: clinical data, experience of use and practical recommendations. Epilepsy and paroxysmal conditions. 2021;13(2):180-187. (In Russ.) https://doi.org/10.17749/2077-8333/epi.par.con.2021.087

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)