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THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS

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Abstract

Abstract: the aim of our research was assessment of the cumulative risk of disorders of metabolism of folic acid in the development of the congenital defect fetus (CDF) in women with epilepsy and receiving antiepileptic drugs (AEDs). Materials and Methods: the study included 124 cases of pregnancy. Results: 54.7% of the daily doses of AEDs exceeded teratogenic levels; at 4.9% - registered the CDF. In 57.1% cases - the CDF associated with hereditary metabolic disorders of folic acid. Conclusions. Women which receive AEDs and have hereditary metabolic disorders of metabolism of folic acid are at increased risk group of developing congenital malformations.

About the Authors

D. V. Dmitrenko
Krasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, Krasnoyarsk
Russian Federation


N. A. Shnayder
Krasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, Krasnoyarsk
Russian Federation


Y. B. Govorina
Krasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, Krasnoyarsk
Russian Federation


A. V. Muravievа
Krasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, Krasnoyarsk
Russian Federation


K. A. Gazenkampf
Krasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, Krasnoyarsk
Russian Federation


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For citation:


Dmitrenko D.V., Shnayder N.A., Govorina Y.B., Muravievа A.V., Gazenkampf K.A. THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS. Epilepsia and paroxysmal conditions. 2014;6(4):16-22. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)