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Mental development of children from paired mothers with epilepsy: assessing remote teratogenic effects and predictors of developmental disorders

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Objective: to study teratogenic effect – the long-term pregnant mother-taken antiepileptic drugs (AEDs) related consequences on paired child mental, social and intellectual development.
Material and methods. There were enrolled 80 subjects: 40 children aged 3–9 years and paired mothers suffering from epilepsy for 3 to 35 years. Thirteen and 27 patients had generalized and focal epilepsy, respectively. Seven mothers were in prolonged remission without taking AEDs, 23 were on monotherapy and 10 were on polytherapy. Child research methods: T. Achenbach's clinical CBCL (The Child Behavior Checklist) scales (for children aged under 5 and 6–18 years), a questionnaire for detecting attention deficit hyperactivity disorder and other behavioral disorders modified by N.N. Zavadenko, Wechsler Intelligence Scale for Children (WISC), Luria batteries of neuropsychological tests adapted by J.M. Glozman (for children aged 3–6 and 7–12 years).
Results. Neuropsychological study and assessment of intelligence revealed problems in the development of praxis, speech, gnostic functions and memory, as well as disproportion in the development of verbal and non-verbal structures of intelligence. The most common behavioral disorders in children were impulsivity, distraction, difficulties in controlling and organizing movements. The most affected spheres were praxis (motor awkwardness, fine motor disorders of the hands) and speech.
Conclusion. The proposed hypothesis that the teratogenic effect of taking AEDs may result in unevenness or delay in developing mental functions in a child was confirmed.

About the Authors

N. F. Mikhailova
Saint Petersburg State University
Russian Federation

Nadezhda F. Mikhailova – PhD (Psych.), Associate Professor, Chair of Developmental Psychology and Differential Psychology, Faculty of Psychology

7-9 Universitetskaya Qy, Saint Petersburg 199034

RSCI SPIN-code: 6203-6013

A. S. Krasko
Saint Petersburg State University
Russian Federation

Anastasia S. Krasko – 2nd-year Postgraduate, Chair of Developmental Psychology and Differential Psychology, Faculty of Psychology

7-9 Universitetskaya Qy, Saint Petersburg 199034

RSCI SPIN-code: 1501-0092

G. V. Odintsova
Russian Polenov Neurosurgical Institute – branch of Almazov National Medical Research Center
Russian Federation

Galina V. Odintsova – MD, PhD, Head of Epilepsy Department

12 Mayakovskiy Str., Saint Petersburg 191014

WoS ResearcherID: G-8940-2012

Scopus Author ID: 55510371000

RSCI SPIN-code: 1303-4651

I. V. Larina
City Epileptology Center, City Psychiatric Hospital No. 6 (hospital with dispensary)
Russian Federation

Irina V. Larina – Neurologist

9 lit. A Obvodnoy Channel Qy, Saint Petersburg 192029

V. A. Mikhailov
Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation

Vladimir A. Mikhailov – Dr. Med. Sc., Head of Neuropsychiatry Department, Scientific Supervisor of Department of Integrative Therapy of Neuropsychiatric Patients and Department of Exogenous Organic Disorders and Epilepsy

3 Bekhterev Str., Saint Petersburg 192019

WoS ResearcherID: B-3272-2017

RSCI SPIN-code: 5563-1009


1. Karlov V.А., Vlasov P.N., Petrukhin V.А., et al. Epilepsy and pregnancy. In: Karlov V.А. Epilepsy in children and adult women and men. A guide for doctors. 2nd ed. Мoscow: BINOM; 2019: 896 p. (in Russ.).

2. Kozhokaru A.B., Karlov V.A., Zhidkova I.A., Serkina A.V. Dysembryogenetic stigmata and physical development in children born to epileptic mothers. Epilepsia i paroksizmalʹnye sostoania / Epilepsy and Paroxysmal Conditions. 2010; 2 (2): 25–31 (in Russ.).

3. Gaily E., Kantola-Sorsa E., Hiilesmaa V., et al. Normal intelligence in children with prenatal exposure to carbamazepine. Neurology. 2004; 62 (1): 28–32.

4. Meador K.J., Baker G.A., Browning N., et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol. 2013; 12 (3): 244–52.

5. Adab N., Kini U., Vinten J., et al. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry. 2004; 75 (11): 1575–83.

6. McCorry D., Bromley R. Does in utero exposure of antiepileptic drugs lead to failure to reach full cognitive potential? Seizure. 2015; 28: 51–6.

7. Scheuerle A.E., Holmes L.B., Albano J.D., et al. Levetiracetam Pregnancy Registry: final results and a review of the impact of registry methodology and definitions on the prevalence of major congenital malformations. Birth Defects Res. 2019; 111 (13): 872–87.

8. Blotière P., Miranda S., Weill A., et al. Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study. BMJ Open. 2020; 10 (6): e034829.

9. Baker G.A., Bromley R.L., Briggs M., et al. IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology. 2015; 84 (4): 382–90.

10. Veroniki A.A., Rios P., Cogo E., et al. Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis. BMJ Open. 2017; 7 (7): e017248.

11. Koch S., Titze K., Zimmermann R.B., et al. Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents. Epilepsia. 1999; 40 (9): 1237–43.

12. Banach R., Boskovic R., Einarson T., Koren G. Long-term developmental outcome of children of women with epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a metaanalysis of cohort studies. Drug Saf. 2010; 33 (1): 73–9.

13. Morrow J., Russell A., Guthrie E., et al. Malformations risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry. 2006; 77 (2): 193–8.

14. Kispayeva T.T., Nurakhmetova A.S. Modern aspects of antiepileptic therapy during pregnancy. S.S. Korsakov Journal of Neurology and Psychiatry. 2018; 118 (7): 101–3 (in Russ.).

15. Vlasov P.N., Petruhin V.A., Gasparyan N.D. Epilepsy and pregnancy. In: Logutova L.S. (Ed.) Extragenital pathology and pregnancy. Moscow: Litterra; 2012: 485–533 (in Russ.).

16. AlSheikh M.H. Prevalence of epilepsy in Saudi pregnant women and possible effects of anti-epileptic drugs on pregnancy outcomes. Neurosciences (Riyadh). 2020; 25 (1): 32–7.

17. Odintsova G.V., Chugunova A.A., Ivanova N.E. Pregravid preparation of patients with epilepsy. In: 15th Anniversary All-Russian Congress with international participation and a specialized exhibition exposition “Outpatient care in the epicenter of women's health from menarche to menopause”. Мoscow; 2019 (in Russ.).

18. Battino D., Tomson T. Management of epilepsy during pregnancy. Drugs. 2007; 67 (18): 2727–46.

19. Kozhokaru A.B., Karlov V.A., Zhidkova I.A., Serkina A.V. Intellectual,

20. psychomotor and speech development of children born to mothers with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2010; 110 (3-2): 25–30 (in Russ.).

21. Wasserman E.L. Intellectual development disorders in actual medical classifications. Defectology. 2020; 3: 31–40 (in Russ.).


For citations:

Mikhailova N.F., Krasko A.S., Odintsova G.V., Larina I.V., Mikhailov V.A. Mental development of children from paired mothers with epilepsy: assessing remote teratogenic effects and predictors of developmental disorders. Epilepsy and paroxysmal conditions. 2021;13(3):211-225.

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