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Mental development of children from paired mothers with epilepsy: assessing remote teratogenic effects and predictors of developmental disorders

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Objective: to study teratogenic effect – the long-term pregnant mother-taken antiepileptic drugs (AEDs) related consequences on paired child mental, social and intellectual development.
Material and methods. There were enrolled 80 subjects: 40 children aged 3–9 years and paired mothers suffering from epilepsy for 3 to 35 years. Thirteen and 27 patients had generalized and focal epilepsy, respectively. Seven mothers were in prolonged remission without taking AEDs, 23 were on monotherapy and 10 were on polytherapy. Child research methods: T. Achenbach's clinical CBCL (The Child Behavior Checklist) scales (for children aged under 5 and 6–18 years), a questionnaire for detecting attention deficit hyperactivity disorder and other behavioral disorders modified by N.N. Zavadenko, Wechsler Intelligence Scale for Children (WISC), Luria batteries of neuropsychological tests adapted by J.M. Glozman (for children aged 3–6 and 7–12 years).
Results. Neuropsychological study and assessment of intelligence revealed problems in the development of praxis, speech, gnostic functions and memory, as well as disproportion in the development of verbal and non-verbal structures of intelligence. The most common behavioral disorders in children were impulsivity, distraction, difficulties in controlling and organizing movements. The most affected spheres were praxis (motor awkwardness, fine motor disorders of the hands) and speech.
Conclusion. The proposed hypothesis that the teratogenic effect of taking AEDs may result in unevenness or delay in developing mental functions in a child was confirmed.

About the Authors

N. F. Mikhailova
Saint Petersburg State University
Russian Federation

Nadezhda F. Mikhailova – PhD (Psych.), Associate Professor, Chair of Developmental Psychology and Differential Psychology, Faculty of Psychology

7-9 Universitetskaya Qy, Saint Petersburg 199034

RSCI SPIN-code: 6203-6013

A. S. Krasko
Saint Petersburg State University
Russian Federation

Anastasia S. Krasko – 2nd-year Postgraduate, Chair of Developmental Psychology and Differential Psychology, Faculty of Psychology

7-9 Universitetskaya Qy, Saint Petersburg 199034

RSCI SPIN-code: 1501-0092

G. V. Odintsova
Russian Polenov Neurosurgical Institute – branch of Almazov National Medical Research Center
Russian Federation

Galina V. Odintsova – MD, PhD, Head of Epilepsy Department

12 Mayakovskiy Str., Saint Petersburg 191014

WoS ResearcherID: G-8940-2012

Scopus Author ID: 55510371000

RSCI SPIN-code: 1303-4651

I. V. Larina
City Epileptology Center, City Psychiatric Hospital No. 6 (hospital with dispensary)
Russian Federation

Irina V. Larina – Neurologist

9 lit. A Obvodnoy Channel Qy, Saint Petersburg 192029

V. A. Mikhailov
Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation

Vladimir A. Mikhailov – Dr. Med. Sc., Head of Neuropsychiatry Department, Scientific Supervisor of Department of Integrative Therapy of Neuropsychiatric Patients and Department of Exogenous Organic Disorders and Epilepsy

3 Bekhterev Str., Saint Petersburg 192019

WoS ResearcherID: B-3272-2017

RSCI SPIN-code: 5563-1009


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For citation:

Mikhailova N.F., Krasko A.S., Odintsova G.V., Larina I.V., Mikhailov V.A. Mental development of children from paired mothers with epilepsy: assessing remote teratogenic effects and predictors of developmental disorders. Epilepsy and paroxysmal conditions. 2021;13(3):211-225.

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