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Assessing efficacy and tolerability of lamotrigine (Sazar®) in therapy of female idiopathic generalized epilepsy: a multicenter study

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Background. Idiopathic generalized epilepsy (IGE) comprises 15–20% among all types of epilepsy. However, specifics of administration for lamotrigine in IGE in the Russian Federation remain poorly investigated, especially in female subjects.

Objective: to assess efficacy and potential adverse events (AEs) in girls and females with preserved childbearing potential and verified IGE upon initial treatment with lamotrigine, upon switching to lamotrigine from a first-antiepileptic drug (AED) that provided no full seizure control and/or was coupled to AEs, as well as while introducing lamotrigine as an adjunctive therapy in case a monotherapy achieved no therapeutic efficacy.

Material and methods. There were enrolled 54 female patients aged 4 to 40 years (mean age 19.3 years, median 11 years). After verifying IGE, patients received a monotherapy with lamotrigine. In case a patient received a first monotherapy course, but achieved no full seizure control and/or was coupled to AEs due to administered AED, lamotrigine was prescribed as a second AED followed by a potential for further switch to a second monotherapy.

Results. It was found that a first monotherapy resulted in the maximum remission rate in patients with isolated generalized tonic-clonic seizures. Lamotrigine efficiently suppressed EEG epiactivity, with observed EEG-remission in 8 out of 16 (50%) patients. While being administered as a second monotherapy, lamotrigine resulted in remission in 87.5% patients. A combination therapy with lamotrigine was required in 22 cases. Most commonly, it was combined with levetiracetam (15 patients). While administering a dual therapy with lamotrigine, remission was observed in 9 patients receiving basal therapy with this drug, as well as 3 and 1 patients receiving valproic acid and topiramate, respectively. Six more patients were observed to demonstrate more than 50% improvement (5 subjects in levetiracetam group and 1 in ethosuximide group).

Conclusions. The study demonstrated high efficacy of administered lamotrigine as a first monotherapy as well as a second monotherapy and a combination therapy in girls, adolescent girls and females with IGE. Lamotrigine resulted in no serious AEs that might lead to its cancellation.

About the Authors

M. V. Barkhatov
Federal Siberian Scientific and Clinical Center, Federal Medical and Biological Agency of Russia
Russian Federation

26 Kolomenskaya Str., Krasnoyarsk Territory, Krasnoyarsk 660037

I. S. Bakhtin
Children's Regional Clinical Hospital; Center of Epileptology and Neurophysiology “EpiTsentr-Yug”
Russian Federation

1 Pobedy Sq., Krasnodar 350007

15 Kondratenko Str., Krasnodar 350007

O. V. Belyaev
Institute of Continuing Medical and Pharmaceutical Education, Volgograd State Medical University; Medical Center of Neurology and Epileptology “EpiTsentr”
Russian Federation

1 Pavshikh Bortsov Sq., Volgograd 400131

14 Donetskaya Str., Volgograd 400131

M. A. Yamin
Rostov State Medical University; Regional Epileptology Center, Regional Consultative and Diagnostic Center
Russian Federation

29 Nakhichevanskiy Aly, Rostov-on-Don 344022

127 Pushkinskaya Str., Rostov-on-Don 344000


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For citations:

Barkhatov M.V., Bakhtin I.S., Belyaev O.V., Yamin M.A. Assessing efficacy and tolerability of lamotrigine (Sazar®) in therapy of female idiopathic generalized epilepsy: a multicenter study. Epilepsy and paroxysmal conditions. 2021;13(4):325-337. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)