MODERN EPILEPTOLOGY. PROBLEMS AND SOLUTIONS
Abstract
Abstract: the primary tasks of the current stage in the therapy of epilepsies and epileptic syndromes are: the widespread introduction of new antiepileptic drugs with innovative mechanisms of action on the "target" pathological epileptic systems; the use of new AEDs, not only as additional therapy of drug-resistant epilepsies, but possibly more rapid transition to new forms of drugs at the early stages of ineffective treatment baseline probes.
About the Author
G. N. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
References
1. Avakyan G.N., Voronina T.A., Khromykh E.A. Epilepsy. Pathogenesis. Pathogenetic therapy. Manual for physicians [Epilepsii. Patogenez. Patogeneticheskaya terapiya. Posobie dlya vrachei]. Moscow. 2007; 148.
2. Brodi M. And for a rational therapy for epilepsy. Proc .: International Conference "Epilepsy - medical and social aspects, diagnosis and treatment [Techenie i ratsionalnaya terapii epilepsii. V kn.: Mezhdunarodnaya konferentsiya «Epilepsiya – mediko-sotsialnye aspekty, diagnostika i lechenie]. Moscow. 2004; 62-73.
3. Gusev E.I., Burd G.S. Epilepsy: Lamictal in patients with epilepsy [Epilepsiya: Lamiktal v lechenii bolnykh epilepsiei]. Moscow. 1994.
4. Karlov V.A. Epilepsy in children and adults, men and women children and adult women and men [Epilepsiya u detei i vzroslykh, zhenshchin i muzhchin detei i vzroslykh zhenshchin i muzhchin]. Moscow. 2010; 720 s.
5. Mizinova M.A., Milchakova L.E., Lebedeva A.V., Kovaleva I.Yu., Pavlov I.A., Gekht A.B. Prilozhenie k Zhurnalu nevrologii i psikhiatrii im. S.S. Korsakova. 2011; 5 (2): 58-65.
6. Mukhin A.Yu., Petrukhin A.S. Epilepsy: the basic principles of diagnosis and treatment of epilepsy [Epilepsiya: osnovnye printsipy diagnostiki i lecheniya epilepsii]. http://www.nevromed.ru/epi/epi_muh.htm
7. Aicardi J. Epilepsy in children: Second Edition. New York. 1994. P. 555.
8. Cram L., Dulac O., Frey H. Commission on antiepileptic drags of the International League Against Epilepsy Guidelines for antiepileptic drug trials in children. 1994.
9. Data on file, Eisai Inc.
10. Forsgren L., Beghi E., Oun A., Sillanpaa M. The epidemiology of epilepsy in Europe a systematic review. Eur J Neurol. 2005 Apr; 12 (4): 245-53.
11. French J.A., Krauss G.L., Biton V. et al. Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304. Neurology. 2012; 79 (6): 589-96.
12. French J.A., Krauss G.L., Steinhoff B.J. et al. Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: results of randomized global phase III study 305. Epilepsia. 2013; 54 (1): 117-25.
13. Glauser T., Ben-Menachem E., Bourgeois B. et al. ILAE Subcommission on AED Guidelines. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2013 Mar; 54 (3): 551-63.
14. Guekht A., Hauser W.A., Milchakova L., Churillin Y., Shpak A., Gusev E.The epidemiology of epilepsy in the Russian Federation. Epilepsy Res. 2010 Dec; 92 (2-3): 209-18.
15. Hauser W.F. The descriptive epidemiology of epilepsy. Epilepsy: translational, clinical and social aspects. Moscow. 2013; 83-117.
16. ILAE. Rational polytherapy of focal epilepsies. Based on the ILAE class. 201.
17. Johannessen S.I., Ben-Menachem E. Management of Focal-Onset Seizures. An Update on Drug Treatment. Drugs. 2006; 66 (13): 1701-1725.
18. Krauss G.L., Serratosa J.M., Villanueva V. et al. Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures. Neurology. 2012; 78 (18): 1408-15.
19. Kwan P., Sander J.W. The natural history of epilepsy: an epidemiological view. J. Neurol. Neurosurg. Psychiatry. 2004; 75.
20. Kwan P. et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010; 51: 1069-77.
21. Kwan P., Brodie M.J. Refractory epilepsy: mechanisms and solutions. Expert Rev Neurother. 2006; 6 (3): 397-406.
22. Noebels J.L., Avoli M., Rogawski M., Olsen R., Delgado-Escueta A.V. Jaspers Basic Mechanisms of the Epilepsies. Epilepsia. 2010; 51 (5): 1-5.
23. Shafer S.Q., Hauser W.A., Annegers J.F., Klaus D.W. EEC and other early predictors of epilepsy remission: a community study. Epilepsia, 1988; 29: 590-600.
24. Wolf P. Praxisbuch Epilepsien. Diagnostik, Behandlung, Rehabilitation – Kohlhammer. Stuttgart. 2003; 394 S.
25. Wolf P. Determinants of outcome in child-hood epilepsy. Acta neurol. Scand. 2005; 112 (182).
26. World Healt Organization. International Classification of Functioning Disability and Healt. 2001.
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For citations:
Avakyan G.N. MODERN EPILEPTOLOGY. PROBLEMS AND SOLUTIONS. Epilepsy and paroxysmal conditions. 2014;6(4):46-49. (In Russ.)
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