UNRESOLVED ISSUES OF INITIAL TREATMENT OF PARTIAL EPILEPSY
Abstract
Abstract: the selection principles for antiepileptic drugs choice for the initial treatment of partial seizures in epileptic patients with newly diagnosed or untreated epilepsy are discussed; evidence-based criteria and opportunities of the personalized therapy of AED therapy are argued in the review.
About the Author
L. V. Lipatova
St. Petersburg V.M. Bekhterev Psychoneurological Research Institute
Russian Federation
Russian Federation
References
1. Vlasov P.N., Orekhova N.V., Leonova M.V. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2010; 2: 66-70. http://medi.ru/doc/0700516.htm.
2. Dmitrenko D.V., Shnaider N.A. Epilepsiya i paroksizmalnye sostoyaniya. 2014; 2: 61-70.
3. Ivanova S.A., Fedorenko O.Yu., Smirnova L.P., Semke A.V., 2013. Sibirskii vestnik psikhiatrii i narkologii. 2013; 1: 12-16.
4. Sychev D.A. Pharmacogenetic testing: clinical interpretation of the results (recommendations for practitioners) [Farmakogeneticheskoe testirovanie: klinicheskaya interpretatsiya rezultatov (rekomendatsii dlya praktikuyushchikh vrachei)]. Moscow. 2011; 41-43.
5. Baulac M., Brodie M.J., Patten A., Segieth J., Giorgi L. (2012) Comparison of the efficacy and tolerability of zonisamide and controlled release carbamazepine in newly diagnosed partial epilepsy: a phase 3, randomized, double-blind, non-inferiority trial. Lancet Neurol. 11: 579-588.
6. Beyreuther B.K., Freitag J., Heeers C., Krebsfanger N., Scharfenecker U., Stohr T. CNS Drug Rev. 2007 Spring; 13 (1): 21-42. Rewiew.
7. Brodie M.J., Overstall P.W., Giorgi L. Multicentre, double-blind, randomized comparison between lamotrigine and carbamazepine in elderly patients with new diagnosed epilepsy. The UK lamotrigine Elderly Study Group. Epilepsy Res. 1999; 37: 81-7.
8. Brodie M.J., Perucca E., Rivlin P., Ben-Menachem E., Meencke H.J. Comparison of the levetiracetam and controlled release carbamazepine in newly diagnosed epilepsy. Neurology. 2007; 68: 402-408.
9. Brodie M.J., Stephen L.J. Outcomes in elderly patients with newly diagnosed and treated epilepsy. Int Rev Neurobiol. 2007; 81: 253-63.
10. Caramelli P., Castro L.H.M. Dementia associated epilepsy. Intern Psychogeriatr 2005; 17: 195-206.
11. Chadwick D. Safety and efficacy of vigabatrin and carbamazepine in newly diagnosed epilepsy: a multicenter randomized double-blind study. Vigabatrin European Monotherapy Study group. Lancet. 1999; 354:13-19.
12. Chen P., Lin J.J., Lu C.S., Ong C.T., Hsieh P.F., Yang C.C., Tai C.T., Wu S.L., Lu C.H., Hsu Y.C., Ro L.S., Lu C.T., Chu C.C., Tsai J.J., Su Y.H., Lan S.H., Sung S.F., Lin S.Y., Chuang H.P., Huang L.C., Chen Y.J., Tsai P.J., Liao H.T., Lin S.Y., Chen C.H., Chung W.H., Yung S.I., Wu J.Y., Chang C.F., Chen L., Chen Y.T., Shen C.Y., Taiwan S.J.S. Consortium. Carbamazepin-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med. 2011 Mar 24; 364 (12): 1126-33.
13. Cloyd J., Yfuser W., Towne A., Ramsay R., Mattson R., Gilliam F. et al. Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Res. 2006; 68 (1): 39-48.
14. Cramer J.A., Fisher R., Ben-Menachem E., French J., Mattson RH. New antiepileptic drugs: comparison of key clinical trials. Epilepsia. 1999; 40: 590-600.
15. Cramer J.A., Steinborn B., Striano P., Hlinkova L., Bergmann A., Bacos I., Baukens C., Buyle S. Non-interventional surveillance study of adverse events in patients with epilepsy. Acta Neurol Scand. DOI: 10.1111/j.1600-0404.2010.0`440.x
16. French J., Kanner A.M., Bautista J. et al. Efficacy and tolerability of the new antiepileptic drugs. I: Treatment of new onset epilepsy. Report of the TTA and QSS subcommittees of the American Academy of Neurology and the American Epilepsy Society. Neurology. 2004; 62: 1252-1264.
17. Friedman D., Honig L.S., Scarmeas N. Seizures and Epilepsy in Alzheimer’s disease. CNS Neurosci Ther. 2012; 18: 285-294.
18. Fritz N., Glogau S., Hoffmann J. et al. Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy. Epilepsy Behav. 2005; 6 (3): 373-81.
19. Gioggi L., Gomez G., O’Neill F., Hammer AE, Risner M. The tolerability of lamotrigine in elgerly patients with epilepsy. Drugs aging. 2001; 18: 621-30.
20. Glauser T., Ben Menachem E., Bourgeois B., Cnaan A., Chadwick D., Guerreiro C., Kalviainen R., Mattson R., Perucca E., Tomson T. Updated ILAE evidence rewire of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. 2013 Jul; 47 (7): 1094-1120.
21. Glauser T., Ben-Menachem E., Bourgeois B., Cnaan A., Chadwick D., Guerreiro C., Kalviainen R., Mattson R., Perucca E., Tomson T. ILAE treatment guidelines: evidence based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2006; 47 (7): 1094-1120.
22. Guerreiro M.M., Vigonius U., Pohlmann H., de Manreza M.L., Fejerman N., Antoniuk S.A., Moore A. A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in children and adolescents with epilepsy. Epilepsy Res. 1997; 27: 205-213.
23. Hauser W.A. Epidemiology of seizures and epilepsy in the elderly. Seizures and epilepsy in the elderly. Boston: Butterworth-Heinemann. 1997; 7-18.
24. Hessdorfer D.C., Hauser W.A., Annegers J.F., et al. Dementia and adult-onset unprovoked seizures. Neurology 1996; 46: 727-30.
25. Kaniwa N., Saito Y., Aihara M., Matsunaga K., Toskin M., Kurose K., Furuya H., takahashi Y., Muramatsu M., Kinoshita S., Abe M., Ikeda H., Kashiwagi M., Song Y., Ueta M., Sotozono C., Ikezawa Z., Hasegawa R., JSAR research group. HLA-B*1511 risk is f risk factor for carbamazepine-induced Steven-Johnson syndrome and toxic epidermal necrosis in Japanese patients. Epilepsia. 2010 Dec; 51 (12): 2461-5.
26. Kanner A.M., Balabanov A.J. The use of monotherapy in patients with epilepsy: an appraisal of new antiepileptic drugs. Curr Neurol Nerosci Rep. 2005; 5: 322-8.
27. Kutluay E., McCague K., Souza J., Beydoun A. Safety and tolerability of oxcarbazepine in erderly patients with epilepsy. Epilepsy Behav. 2003; 4: 175-80.
28. Larner A.J. Epileptic seizures in AD patients. Neuromol Med. 2010; 12: 71-77.
29. Larner A.J. Presenilin-1 mutation Alzheimer’s disease: a genetic epilepsy syndrome? Epilepsy Behav. 2011; 21: 20-22.
30. Malphrus A.D., Wilfong A.A. Use of newer antiepileptic drugs in pediatric epilepsies. Curr Treat Options Neurol. 2007; 9: 256-67.
31. Mattson R.H., Cramer J.A., Collins J.F., Smith D.B., Delgado-Escueta A.V., Browne T.R., Williamson R.D., Treiman D.M., McNamara J.O., McCuchen C.B., Homan R.W., Crill W.E., Lubozynski M.F., Rosental N.P., Mayersdorf A. Comparison of carbamazepine, phenobarbital, phenytoin and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl Med. 1985; 313: 145-151.
32. Mendez M.F., Lim G.T.H. Seizures in elderly patients with dementia. Drug Aging. 2003; 20: (11): 791-803.
33. Mendiratta A., Pedley T.A. Seizures and epilepsy in the elderly. In: Shorvon S., Pedley T.A., eds The epilepsies 3. Philadelphia. 2009; 177-93.
34. Mintzer S., Mattson R.T. Should enzyme-inducing antiepileptic drugs be considered first-line agents? Epilepsia. 2009; 50 (8): 42-50.
35. Pack A.M., Olarte L.S., Morrell M.J. et al. Bone mineral density in an outpatient population receiving enzyme-inducing Antiepileptic drugs. Epilepsy Behav. 2003; 4: 169-74.
36. Patsalos P.N., Duncan J. Antiepileptic drugs: a review of clinically significant drug interactions. Drug Saf. 1993; 9: 156-86.
37. Perucca E., Meador KJ. Adverse effects of antiepileptic drugs. Acta Neurol Scand. 2005; 112: 30-5.
38. Pohlmann-Eden B. Issues when treating epilepsy in the elderly. Acta Neurol Scand. 2005; 181: 40.
39. Ramsay R.E., Rowan J., Pryor F.M. Special considerations in treating the elderly patients with epilepsy. Neurology. 2004; 62 (2): 24-29.
40. Rao S.C., Dove G., Cascino G.D., Petersen R.C. Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome. Epilepsy Behav. 2009; 14: 118-20.
41. Rosenfeld W., McShea C., Doty P. Evaluation a long-term treatment with lacosamide for partial-onset seizures in the elderly. 66th Annual Meeting of the American Epilepsy Society. San Diego, CA November 30-December 4, 2012.
42. Rowan A.J., Ramsay R.E., Collins J.F. et al. A cooperative Study 428 Group. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology. 2005; 64 (11): 1868-73.
43. Saetre E., Perucca E., Collins J.F. et al; VA Cooperative Study 428 Group. An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia. 2007; 48: 1291-302.
44. Schiller Y, Najjar Y. Quantifying the response to antiepileptic drugs: effect of past treatment history. Neurology. 2008; 70: 54-65.
45. Stenhouse S.A., Ellis R., Zuberi S. SCN1A Genetic Test for Dravet Syndrome (Severe Myoclonic Epilepsy of Infancy and its Clinical Subtypes) for use in the Diagnosis, Prognosis, Treatment and Management of Dravet Syndrome. PLOS Currents Evidence on Genomic Tests. Edition 1. 2013 Apr 25; DOI: 10.1371/ currents.eogt. c553b83d745dd79bfb61eaf35e522b0b.
46. Stephen L.J., Brodie M.J. Epilepsy in elderly people. Lancet. 2000; 355: 1441-6.
47. Trinka E., Giorgi L., Patten A., Segieth J. Safety and tolerability of zonisamide in elderly patients with epilepsy. Acta Neurol Scand. 2013; 128: 422-428.
48. Werhahn K.J., Klimpe S., Balkaya S., Trinka E., Kramer G. The safety and efficacy of add-on levetiracetam in erderly patients with focal epilepsy: a one-year observational study. Seizure. 2011; 20: 305-11.
Review
For citations:
Lipatova L.V. UNRESOLVED ISSUES OF INITIAL TREATMENT OF PARTIAL EPILEPSY. Epilepsy and paroxysmal conditions. 2014;6(4):55-61. (In Russ.)
Views: 458
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
