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EFFECT OF KETOGENIC DIET ON COGNITIVE AND MOTOR FUNCTIONS IN CHILDREN WITH DRUG-RESISTANT EPILEPSY

https://doi.org/10.17749/2077-8333.2016.8.1.037-042

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Abstract

Objective. We describe our experience of using the ketogenic diet (KD) for the treatment of drug-resistant epilepsy. Refractory epilepsy causing irreparable damage to the health of patients giving an epileptic encephalopathy with regression of cognitive and motor functions especially in childhood.

Materials and methods. We observed 95 patients, the children from 1 year to 14 years old with refractory epilepsy with frequent seizures.

Results. For 20% of children with drug-resistant epilepsy using KD with or without anticonvulsant therapy resulted to treating and prevention of all types of seizures. The improvement of the quality of life for them we estimated by Hague and QLS scales. Using the KD we have achieved the reliable positive changes in the psychomotor development of patients tested by Griffits 1, Griffits 2, and GMFM scales.

Conclusions. KD is an effective treatment for refractory epilepsy. The overall efficiency (seizure reducing more than 50%) was observed in 48 patients, representing 48% of the total. The use of the KD will improve the quality of life of patients.

About the Authors

E. G. Lukyanova
Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Medical Center «Nevromed», Moscow
Russian Federation

neurologist doctor, Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Health Department. Address: Aviatorov str. 38, Moscow, Russia, 119620. Tel.: +7(495)7309847 (48, 52, 54); Medical Center «Nevromed». Address: Bol'shoi Ovchinnikovskii pereulok, 17-1-3, Moscow, Russia, 115184. Tel.: +7(495)3746140



S. O. Ayvazyan
Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Medical Center «Nevromed», Moscow
Russian Federation

MD, assistant chair of neurology childhood GBOU DPO RMAPO Health Ministry RF; Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Health Department. Address: ul. Aviatorov, 38, Moscow, Russia, 119620. Tel.: +7(495)7309847 (48, 52, 54); Medical Center «Nevromed» Address: Bol'shoi Ovchinnikovskii pereulok, 17-1-3, Moscow, Russia, 115184. Tel.: +7(495)3746140



K. V. Osipova
Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Medical Center «Nevromed», Moscow
Russian Federation

neurologist doctor, Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Health Department. Address: Aviatorov str. 38, Moscow, Russia, 119620. Tel.:
+7(495)7309847 (48, 52, 54); Medical Center «Nevromed». Address: Bol'shoi Ovchinnikovskii pereulok, 17-1-3, Moscow, Russia, 115184. Tel.: +7(495)3746140



T. N. Sorvacheva
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation

MD, Head of Dietetics and Nutrition GBOU DPO RMAPO Health Ministry RF. Address: ul. Barrikadnaya, 2/1, Moscow, Russia, 125993. Tel.: +7(499)6131714



E. A. Pyreva
Medical Center «Nevromed», Moscow Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation

PhD, assistant chair of Dietetics and Nutrition GBOU DPO RMAPO Health Ministry. Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Health Department. Address: ul. Aviatorov, 38, Moscow, Russia, 119620. Tel.: +7(495)7309847 (48, 52, 54). Medical Center «Nevromed». Address: Bol'shoi Ovchinnikovskii pereulok, 17-1-3, Moscow, Russia, 115184. Tel.: +7(495)3746140



References

1. Орлов Ю. А. Оценка качества жизни пациентов с поражением центральной нервной системы. Украинский нейрохирургический журнал. 2001; 1: 89-94 / Ukrainskii neirokhirurgicheskii zhurnal. 2001; 1: 89-94

2. Bourgeois В. Establishment of pharmacorcsistcnce, ch 58 in Epileptic seizures and Syndroms, edited by p. Wolf. 1994; 591-597.

3. Bough K. J., Rho J. M. Anticonvulsant mechanisms of the ketogenic diet. Epilepsia. 2007; 48: 43-58.

4. Freeman J. M., Kossoff E. H., Freeman J. B., Kelly M. T. The ketogenic diet: a treatment for epilepsy in children and others. 4th ed. Demos, New York. 2006.

5. Freeman J., Veggiotti P., Lanzi G., Tagliabue A., Perucca E. The ketogenic diet: from molecular mechanisms to clinical effects. Epilepsy Research. 2006; 68: 145-180.

6. Hauser W. A., Annegers J. F., Rocca W. A. Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin Proc. 1996; 71: 576-86.

7. Kossoff Е. et al. Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group. Epilepsia. 2009 Feb; 50 (2): 304-17

8. Kwan P., Arzimanoglou A., Berg A. T., Brodie M. J., Allen Hauser W., Mathern G., Moshй S. L., Perucca E., Wiebe S., French J. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010; 51: 6: 1069-1077.

9. Likhodii S. S., Musa K., Mendonca A., Dell C., Burnham W. M., Cunnane S. C. Dietary fat, ketosis, and seizure resistance in rats on theketogenic diet. Epilepsia. 2000; 41: 1400-1410.

10. Morris A. A. Cerebral ketone body metabolism. Journal of Inherited Metabolic Disease. 2005; 28: 109-121.

11. Panayiotopoulos C. P. A Clinical Guide to Epileptic Syndromes and their Treatment. 2010.

12. The official website of the International League Against (ILAE). URL: http://www.ilae.org/SiteSearch/SearchResults (accessed: 15.12.2015).

13. Willie E. Surgical treatment of epilepsy in pediatric patients. Can J. Neurological Sciens. 2000 Maj; 27 (2): 106-10.


For citation:


Lukyanova E.G., Ayvazyan S.O., Osipova K.V., Sorvacheva T.N., Pyreva E.A. EFFECT OF KETOGENIC DIET ON COGNITIVE AND MOTOR FUNCTIONS IN CHILDREN WITH DRUG-RESISTANT EPILEPSY. Epilepsia and paroxyzmal conditions. 2016;8(1):37-42. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.1.037-042

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)