EFFECT OF KETOGENIC DIET ON COGNITIVE AND MOTOR FUNCTIONS IN CHILDREN WITH DRUG-RESISTANT EPILEPSY
https://doi.org/10.17749/2077-8333.2016.8.1.037-042
Abstract
Objective. We describe our experience of using the ketogenic diet (KD) for the treatment of drug-resistant epilepsy. Refractory epilepsy causing irreparable damage to the health of patients giving an epileptic encephalopathy with regression of cognitive and motor functions especially in childhood.
Materials and methods. We observed 95 patients, the children from 1 year to 14 years old with refractory epilepsy with frequent seizures.
Results. For 20% of children with drug-resistant epilepsy using KD with or without anticonvulsant therapy resulted to treating and prevention of all types of seizures. The improvement of the quality of life for them we estimated by Hague and QLS scales. Using the KD we have achieved the reliable positive changes in the psychomotor development of patients tested by Griffits 1, Griffits 2, and GMFM scales.
Conclusions. KD is an effective treatment for refractory epilepsy. The overall efficiency (seizure reducing more than 50%) was observed in 48 patients, representing 48% of the total. The use of the KD will improve the quality of life of patients.
About the Authors
E. G. Lukyanova
Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow
Medical Center «Nevromed», Moscow
Russian Federation
Russian Federation
neurologist doctor, Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Health Department. Address: Aviatorov str. 38, Moscow, Russia, 119620. Tel.: +7(495)7309847 (48, 52, 54); Medical Center «Nevromed». Address: Bol'shoi Ovchinnikovskii pereulok, 17-1-3, Moscow, Russia, 115184. Tel.: +7(495)3746140
S. O. Ayvazyan
Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow
Medical Center «Nevromed», Moscow
Russian Federation
Russian Federation
MD, assistant chair of neurology childhood GBOU DPO RMAPO Health Ministry RF; Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Health Department. Address: ul. Aviatorov, 38, Moscow, Russia, 119620. Tel.: +7(495)7309847 (48, 52, 54); Medical Center «Nevromed» Address: Bol'shoi Ovchinnikovskii pereulok, 17-1-3, Moscow, Russia, 115184. Tel.: +7(495)3746140
K. V. Osipova
Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow
Medical Center «Nevromed», Moscow
Russian Federation
Russian Federation
neurologist doctor, Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Health Department. Address: Aviatorov str. 38, Moscow, Russia, 119620. Tel.:
+7(495)7309847 (48, 52, 54); Medical Center «Nevromed». Address: Bol'shoi Ovchinnikovskii pereulok, 17-1-3, Moscow, Russia, 115184. Tel.: +7(495)3746140
T. N. Sorvacheva
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation
Russian Federation
MD, Head of Dietetics and Nutrition GBOU DPO RMAPO Health Ministry RF. Address: ul. Barrikadnaya, 2/1, Moscow, Russia, 125993. Tel.: +7(499)6131714
E. A. Pyreva
Medical Center «Nevromed», Moscow
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation
Russian Federation
PhD, assistant chair of Dietetics and Nutrition GBOU DPO RMAPO Health Ministry. Scientific-Practical Center of specialized medical care for children named after V. F. Voyno-Yasenetskogo, Moscow Health Department. Address: ul. Aviatorov, 38, Moscow, Russia, 119620. Tel.: +7(495)7309847 (48, 52, 54). Medical Center «Nevromed». Address: Bol'shoi Ovchinnikovskii pereulok, 17-1-3, Moscow, Russia, 115184. Tel.: +7(495)3746140
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Review
For citations:
Lukyanova E.G., Ayvazyan S.O., Osipova K.V., Sorvacheva T.N., Pyreva E.A. EFFECT OF KETOGENIC DIET ON COGNITIVE AND MOTOR FUNCTIONS IN CHILDREN WITH DRUG-RESISTANT EPILEPSY. Epilepsy and paroxysmal conditions. 2016;8(1):37-42. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.1.037-042
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