EPILEPSY AT ADULTS: GENDER COMORBIDE DISORDERS, APPLICATION OF VALPROATES
Abstract
Was carried out the analysis of basic somatic and reproductive disorders at adults’ epilepsy, as well as the role of valproates in the epilepsy therapy at the modern stage. The individual therapy of adults’ epilepsy along with forms of epilepsy/types of epileptic attacks, should mandatory take into account such things as somatic pathology, sexual function and the condition of the emotional-volitional sphere. The valproic acis remains the substance, referred to the first choice group in the treatment of idiopathic (generalized/focal) cryptogenic/symptomatic focal and non-differentiated epilepsies at patients from different age groups with broad spectrum of the accompanying somatic pathology and at men. The valporate is the selection choice at renal failures, kidney transplantation, heart diseases, pulmonary pathologies, brain tumors, different psychic disorders. The substance is not recommended in case of liver diseases with its decompensation, of the bone marrow and liver transplantation, porphyria, adiposity and during pregnancy. For women the valproic acid is applied with reserve in case of the inefficiency of other AED with mandatory information of the patient on possible consequences of the substance application.
About the Author
P. N. Vlasov
Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
MD, Professor of Neurology of General Medical Faculty and Neurosurgery, Medical Faculty of the Moscow State University of Medicine and Dentistry. Address: ul. Delegatskaya, d. 20-1, Moscow, Russia, 127473. Tel.: +7(495)2612843
References
1. Vlasov P. N. Gender aspects of epilepsy. Chapter 15 in the book. «Epilepsy», edited by NG Neznanov [Gendernye aspekty epilepsii. Glava 15. v kn. «Epilepsiya» pod obshchei redaktsiei N. G. Neznanova (in Russian)]. SPb. 2010: 408-451.
2. Vlasov P. N., Filatova N. V., Naumova G. I. Epilepsy in women, hormonal aspect. In the book .: Modern Epileptology. Ed. EI Gusev, AB Hecht [Epilepsiya u zhenshchin,
3. gormonal’nyi aspekt. V kn.: Sovremennaya epileptologiya. Pod red. E. I. Guseva, A. B. Gekht (in Russian)]. Moscow. 2011; 269-276.
4. Zhidkova I., Karlov V., Adamyan L. Epilepsy and women’s reproductive health [Epilepsiya i reproduktivnoe zdorov’e zhenshchiny (in Russian)]. Palmarium academic publishing. 2012. 278s.
5. Zenkov L. R. RMZh. 2009; 17 (11): 726-733.
6. Karlov V. A. Epilepsy in children and adult women and men: a guide for physicians [Epilepsiya u detei i vzroslykh zhenshchin i muzhchin: Rukovodstvo dlya vrachei (in Russian)]. Moscow. 2010; 720 s.
7. Bardai A., Blom M. T., van Noord C., Verhamme K. M., Sturkenboom M. C.J.M., Tan H. L. Sudden cardiac death is associated both with epilepsy and with use of antiepileptic medications. Heart. 2015; 101 (1): 17-22.
8. Faught E. Pharmacokinetic considerations in prescribing antiepileptic drugs. Epilepsia. 2001; 42 (4): 19-23.
9. Goldberg-Stern H., Yaacobi E., Phillip M., de Vries L. Endocrine effects of valproic acid therapy in girls with epilepsy: a prospective study. Eur. J. Paediatr. Neurol. 2014; 18(6): 759-765.
10. Hellmis E. Sexual problems in males with epilepsy — an interdisciplinary challenge! Seizure. 2008; 17 (2): 136-140.
11. Herzog A. Disorders of reproduction in patients with epilepsy: Primary neurological mechanisms. Seizure. 2008; 17 (2): 101-110.
12. Jobe P. C., Dailey J. W., Wernicke J. F. A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders. Crit. Rev. Neurobiol. 1999; 13: 317-356.
13. Mula M., Kanner A. M., Schmitz B., and Schachter S. Antiepileptic drugs and
14. suicidality: An expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology. Epilepsia. 2013; 54 (1): 199-203.
15. Ruiz-Gimenez J., Sanchez-Alvarez J.C., Canadillas-Hidalgo F., Serrano-Castro
16. P. J. Antiepileptic treatment in patients with epilepsy and other comorbidities. Seizure. 2010; 19: 375-382.
17. Vajda F. Valproate and neuroprotection. J. Clinical Neuroscience. 2002; 9: 508-514.
For citation:
Vlasov P.N. EPILEPSY AT ADULTS: GENDER COMORBIDE DISORDERS, APPLICATION OF VALPROATES. Epilepsy and paroxysmal conditions. 2016;8(1):43-49. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.1.043-049
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