COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE
Abstract
The purpose of this study was to examine in experiment anticonvulsant and antihypoxic action of 2-ethyl-6-methyl-3-hydroxypyridine succinate medications — Astroks in injectable form (vial of 100 mg in 2 ml) compared with Mexidol injectable form (vial of 100 mg in 2 ml) and the substance 2-ethyl-6- methyl-3-hydroxypyridine succinate (EMHPS).
Materials and methods. Simulation of primary generalized eizures was performed using the maximal electroshock (MES) and pentylenetetrazole injection. Antihypoxic effects of drugs was studied on the model of normobaric hypoxia with hypercapnia.
Results: it was found that astroks injection at a dose of 200 mg/kg has a similar antihypoxic and anticonvulsant efficacy with EMHPS substance. Compared to injectable form of Meksidol astroks has similar efficacy in the test of antagonism with MES. Astroks exceeds the effect of Mexidol in the test of antagonism with pentylenetetrazole and has more severe antihypoxic action.
Conclusion. Аstroks injectable has pronounced antihypoxic and anticonvulsant action in the experiment which have some advantages over injectable Meksidol.
About the Authors
T. A. Voronina
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation
Russian Federation
professor, MD, head of the Laboratory of Psychopharmacology Institute of Pharmacology named V. V. Zakusov RAS. Address: ul. Baltiiskaya, 8, 125315, Moscow, Russia. Tel.: +7(495)6012414
S. A. Litvinova
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation
Russian Federation
Ph.D., Leading Research Fellow, Institute of Pharmacology named V. V. Zakusov RAS. Address: ul. Baltiiskaya, 8, Moscow, Russia, 125315. Tel.: +7(495)6012414
L. N. Nerobkova
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation
Russian Federation
Ph.D., Senior Research Fellow, Institute of Pharmacology named V. V. Zakusov RAS. Address: ul. Baltiiskaya, 8, Moscow, Russia, 125315. Tel.: +7(495)6012414
G. G. Avakyan
The Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation, Moscow
Russian Federation
Russian Federation
MD, PhD, Department of Neurology, Neurosurgery and Medical Genetics, Medical University RNIMU them NI Pirogov. Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997. Tel.: 79151879506.
I. O. Gaidukov
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation
Russian Federation
Junior Research Fellow, Institute of Pharmacology named V. V. Zakusov RAS. Address: ul. Baltiiskaya, 8, Moscow, Russia, 125315. Tel.: +7(495)6012414
G. N. Avakyan
The Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation, Moscow
Russian Federation
Russian Federation
MD, Honored Scientist of Russia, Professor of Neurology and Neurosurgery, Medical University RNIMU them NI Pirogov. Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997
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For citation:
Voronina T.A., Litvinova S.A., Nerobkova L.N., Avakyan G.G., Gaidukov I.O., Avakyan G.N. COMPARATIVE ANTICONVULSANT AND ANTIHYPOXIC EFFECTS OF ASTROKS AND MEXIDOL IN INJECTABLE FORM AND 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE SUBSTANCE. Epilepsia and paroxyzmal conditions. 2016;8(1):75-82. (In Russ.) https://doi.org/10.17749/2077-8333.2016.8.1.075-082
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