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NEW BIOMOLECULAR TARGETS FOR ANTIEPILEPTIC DRUGS

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Abstract

The review presents data on new antiepileptic drugs (AEDs), which have been applied in medical practice in recent years. New AEDs have different spectrum of pharmacological effects and mechanism of action. The authors presented the classification of AEDs for their ability to influence the processes of excitation and inhibition in the central nervous system. This article contains information about AEDs, blocking or modifying the ionic conductivity of the voltagedependent Na+ and Ca++-channels; AEDs, blocking glutamate receptors; AEDs, activating the ionic conductivity of K+ channels; AEDs, enhancing the braking effect of GABA

About the Authors

T. A. Voronina
Zakusov Institute of Pharmacology, Moscow
Russian Federation

Voronina Tat'yana Aleksandrovna – MD, Honored Scientist of Russia, professor, head of the Laboratory of Psychopharmacology.

Address: Baltiiskaya str., 8, Moscow, 125315, Russia



G. G. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation

Avakyan Georgii Gagikovich – MD, PhD, Department of Neurology, Neurosurgery and Medical Genetics. 

Address: Ostrovityanova str., 1, Moscow, 117997, Russia.



L. N. Nerobkova
Zakusov Institute of Pharmacology, Moscow
Russian Federation

Nerobkova Lyubov' Nikolaevna – Ph.D., Senior Research Fellow.

Address: Baltiiskaya str., 8, Moscow, 125315, Russia



S. A. Litvinova
Zakusov Institute of Pharmacology, Moscow
Russian Federation

Litvinova Svetlana Aleksandrovna – Ph.D., Leading Researcher.

Address: Baltiiskaya str., 8, Moscow, 125315



G. N. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation

Avakyan Gagik Norairovich – MD, Honored Scientist of Russia, Professor of Neurology, Neurosurgery and Medical Genetics.

Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997.



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For citation:


Voronina T.A., Avakyan G.G., Nerobkova L.N., Litvinova S.A., Avakyan G.N. NEW BIOMOLECULAR TARGETS FOR ANTIEPILEPTIC DRUGS. Epilepsy and paroxysmal conditions. 2015;7(4):59-65. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)