OPPORTUNITIES TO OPTIMIZE ANTIEPILEPTIC THERAPY WITH USE OF PHARMACOGENETIC BIOMARKERS
Abstract
Pharmacogenetics allows to determine the cause of the ineffectiveness of drug therapy for certain groups of people who do not respond to treatment or exhibiting an inadequate response to a standard dose of the drug. Pharmacogenetic test can predict the speed and features of a metabolism of antiepileptic drugs in patients with epilepsy, depending on the activity involved in their metabolism enzyme systems and conveyors, that allows to individualize drug therapy in epileptological practice, to avoid side effects.
About the Authors
T. V. Dokukina
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus
Belarus
Dokukina Tat’yana Vasil’evna – MD, deputy director for scientific work.
Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.
M. V. Makhrov
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus
Belarus
Makhrov Mikhail Valer’evich – Researcher at the Department of Mental and Behavioural Disorders.
Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.
I. V. Gaidukevich
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Gaidukevich Irina Vital’evna – Researcher at the Laboratory of Molecular Diagnostics and Biotechnology.
Address: V.F.Kuprevicha str., 5/2, Minsk, Belarus, 220141.
A. A. Gilep
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Gilep Andrey Alexandrovich – PhD, Head of the Laboratory of Molecular Diagnostics and Biotechnology.
Address: V.F.Kuprevicha str., 5/2, Minsk, Belarus, 220141.
T. S. Golubeva
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus
Belarus
Golubeva Tat’yana Sergeevna – PhD, Leading Researcher at the Department of Mental and Behavioural Disorders.
Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.
F. P. Khlebokazov
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus
Belarus
Khlebokazov Fedor Petrovich – PhD, Head of the Department for the treatment of psychiatric disorders due to epilepsy.
Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.
N. N. Misyuk
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus
Belarus
Misyuk Nikolai Nikolaevich – PhD, Doctor of functional diagnostics.
Address: Dolginovskiitrakt, 152, Minsk, Belarus, 220053.
P. P. Korolevich
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus
Belarus
Korolevich Pavel Pavlovich – Researcher at the Department of Mental and Behavioural Disorders.
Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.
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Review
For citations:
Dokukina T.V., Makhrov M.V., Gaidukevich I.V., Gilep A.A., Golubeva T.S., Khlebokazov F.P., Misyuk N.N., Korolevich P.P. OPPORTUNITIES TO OPTIMIZE ANTIEPILEPTIC THERAPY WITH USE OF PHARMACOGENETIC BIOMARKERS. Epilepsy and paroxysmal conditions. 2015;7(4):22-28. (In Russ.)
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