Preview

Epilepsy and paroxysmal conditions

Advanced search

OPPORTUNITIES TO OPTIMIZE ANTIEPILEPTIC THERAPY WITH USE OF PHARMACOGENETIC BIOMARKERS

Full Text:

Abstract

Pharmacogenetics allows to determine the cause of the ineffectiveness of drug therapy for certain groups of people who do not respond to treatment or exhibiting an inadequate response to a standard dose of the drug. Pharmacogenetic test can predict the speed and features of a metabolism of antiepileptic drugs in patients with epilepsy, depending on the activity involved in their metabolism enzyme systems and conveyors, that allows to individualize drug therapy in epileptological practice, to avoid side effects. 

About the Authors

T. V. Dokukina
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus

Dokukina Tat’yana Vasil’evna – MD, deputy director for scientific work. 

Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.



M. V. Makhrov
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus

Makhrov Mikhail Valer’evich – Researcher at the Department of Mental and Behavioural Disorders. 

Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.



I. V. Gaidukevich
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus

Gaidukevich Irina Vital’evna – Researcher at the Laboratory of Molecular Diagnostics and Biotechnology.

Address: V.F.Kuprevicha str., 5/2, Minsk, Belarus, 220141. 



A. A. Gilep
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk
Belarus

Gilep Andrey Alexandrovich – PhD, Head of the Laboratory of Molecular Diagnostics and Biotechnology. 

Address: V.F.Kuprevicha str., 5/2, Minsk, Belarus, 220141. 



T. S. Golubeva
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus

Golubeva Tat’yana Sergeevna – PhD, Leading Researcher at the Department of Mental and Behavioural Disorders. 

Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.



F. P. Khlebokazov
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus

Khlebokazov Fedor Petrovich – PhD, Head of the Department for the treatment of psychiatric disorders due to epilepsy. 

Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.



N. N. Misyuk
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus

Misyuk Nikolai Nikolaevich – PhD, Doctor of functional diagnostics. 

Address: Dolginovskiitrakt, 152, Minsk, Belarus, 220053.



P. P. Korolevich
Republican Scientific and Practical Center for Mental Health, Minsk
Belarus

Korolevich Pavel Pavlovich – Researcher at the Department of Mental and Behavioural Disorders. 

Address: Dolginovskii trakt, 152, Minsk, Belarus, 220053.



References

1. Kukes V.G., Sychev D.A., Ramenskaya G.V., Ignat'ev I.V. Biomeditsina. 2007; 6: 29-47.

2. Mikheeva O.M. Eksperimental'nayaiklinicheskayagastroenterologiya. 2011; 1: 121-124.

3. Syunyakov T.S. Psikhiatriyaipsikhofarmakoterapiyaim. P.B. Gannushkina. 2014; 3: 25-35.

4. Innocenti F. Pharmacogenomics: Methods and Protocols (Methods in Molecular Biology). Humana Press. 2005; 224 p.


For citation:


Dokukina T.V., Makhrov M.V., Gaidukevich I.V., Gilep A.A., Golubeva T.S., Khlebokazov F.P., Misyuk N.N., Korolevich P.P. OPPORTUNITIES TO OPTIMIZE ANTIEPILEPTIC THERAPY WITH USE OF PHARMACOGENETIC BIOMARKERS. Epilepsy and paroxysmal conditions. 2015;7(4):22-28. (In Russ.)

Views: 220


ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)