EFFICACY AND SAFETY IN THERAPY OF EPILEPSY IN ELDERLY
Abstract
Abstract: the review substantiates actuality of problem of epilepsy in elderly due to it prevalence in this age population, difficulties of diagnostic which caused by atypical clinical symptoms, subclinical and masked forms of the disease. Principles of rational therapy of epilepsy in elderly with due account the physiological features, comorbidity and co-medication are discussed.
About the Author
L. V. Lipatova
V.M. Bekhterev Psychoneurological Research Institute, St. Petersburg
Russian Federation
Russian Federation
References
1. Блинов Д.В., Сандуковская С.И. Статистико-эпидемиологическое исследование заболеваемости неврологического профиля на примере детского стационара. Эпилепсия и пароксизмальные состояния. 2010; 2 (4): 12-22.
2. Блинов Д.В. Общность ряда нейробиологических процессов при расстройствах деятельности ЦНС. Эпилепсия и пароксизмальные состояния. 2011; 2: 28-33.
3. Власов П.Н., Шахабасова З.С., Филатова Н.В. Эпилепсия, впервые выявленная у пожилых пациентов: диагностика, дифференциальная диагностика, терапия. Фарматека. 2010; 7: 40-47.
4. Генералов В.О., Авакян Г.Н., Садыков Т.Р., Казакова Ю.В. Мультифокальная эпилепсия взгляд современного нейрофизиолога. Эпилепсия и пароксизмальные состояния. 2012; 4 (2): 13-20.
5. Меликян Э.Г. Эпилепсия у больных пожилого возраста (клинико-нейрофизиологическое и фармакокинетическое исследование): дисс. канд. мед. наук. 2004; 171 c.
6. Овсянникова Т.В., Макаров И.О., Боровкова Е.И., Куликов И.А. Местная терапия урогенитальных нарушений в пери- и постменопаузе. Акушерство, гинекология и репродукция. 2010; 3: 25-28.
7. Abbasi F., Krumholz A., Kittner S.J. et al. Effects of menopause on seizures in women with epilepsy. Epilepsia. 1999; 40: 205-10.
8. Boling W., Andermann F., Reutens D. et al. Surgery for temporal lobe epilepsy in older patients. J. Neurosurg. 2001; 95: 2: 242-248.
9. Brodie M.J., Overstall P.W., Giorgi L. Multicentre, double-blind, randomized comparison between lamotrigine and carbamazepine in elderly patients with new diagnosed epilepsy. The UK lamotrigine Elderly Study Group. Epilepsy Res. 1999; 37: 81-7.
10. Brodie M.J., Stephen L.J. Outcomes in elderly patients with newly diagnosed and treated epilepsy. Int. rev. Neurobiol. 2007; 81: 253-63.
11. Cloyd J., Yfuser W., Towne A., Ramsay R., Mattson R., Gilliam F. et al. Epidemiological and medical aspects of epilepsy in the elderly Epilepsy Res. 2006; 68 Suppl 1: 39-48.
12. Crawford P. Best Practice Guidelines for the Management of Women with Epilepsy. Epilepsia. 2005; 46 (9): 117-124.
13. Elliott J.O., Darby J.M., Jacobson M.P. Bone loss in epilepsy: barriersto prevention, diagnosis, and treatment. Epilepsia. 2004; 45 (7): 258.
14. Harden C.L. Menopause and bone density issues for women with epilepsy. Neurology. 2003; 61: 16-22.
15. Harden C.L., Herzog A.G., Nikolov B.G. et al. Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled study. Epilepsia. 2006; 47: 1447-1451.
16. Hauser W.A. Epidemiology of seizures and epilepsy in the elderly. Seizures and epilepsy in the elderly. Boston: Butterworth-Heinemann. 1997; 7-18.
17. Herzog A.G. Menstrual disorders in women with epilepsy. Neurology. 2006; 66 (3): 23-28.
18. Mendiratta A., Pedley T.A. Seizures and epilepsy in the elderly. In: S. Shorvon, T.A. Pedley, eds. The epilepsies 3. Philadelphia. 2009: 177-93.
19. Panayiotopoulos С.Р. Principles of Therapy in the Epilepsies. 2010; 220-221.
20. Patsalos P.N. Anti-epileptic drugs interactions. A clinical Guide. Cranleigh. 2005.
21. Perucca E., Bercowitz D., Birnbaum A. et al. Pharmacological and clinical aspects of antiepileptic drugs use in the elderly. Epilepsy Res. 2006; 68 (1): 49-63.
22. Ramsay R.E., Macias F.M., Rowan A.J. Diagnosing epilepsy in the elderly. Int rev neurobiol. 2007; 81: 129-51.
23. Rowan A.J., Ramsay R.E., Collins J.F. et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology. 2005; 64: 1868-73.
24. Shorvon S. Handbook of Epilepsy Treatment. 3rd Edition. 2010; p. 134.
25. Sirven J.I. Treatment of the elderly with epilepsy. In: J.A. French, N. Delanty, eds. Therapeutic Strategies in Epilepsy. Oxford. 2009; 173-85.
26. Thomas P., Beaumanoir A., Genton P. et al. ‘De novo’ absence status in on late onset; report of 11 cases. Neurol. 1992; 42: 104-10.
27. Vespa P.M., O’Phelan K., Shan M. et al. Acute seizure after intracerebral hemorrhage: a factor progressive midline shift and outcome. Neurology. 2003; 60: 1441-1446.
For citation:
Lipatova L.V. EFFICACY AND SAFETY IN THERAPY OF EPILEPSY IN ELDERLY. Epilepsy and paroxysmal conditions. 2013;5(2):58-61. (In Russ.)
Views: 117
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
