Bioelectronic medicine: a new frontier for autonomic nervous system disorders

Bioelectronic medicine is a field of study that is constantly evolving as a result of recent advancements and improvements in bioelectronic technology, which have led to novel approaches and perspectives in disease diagnosis and therapy, particularly in the inflammatory reflex immuno-regulatory functioning and, vagus nerve stimulation (VNS). The vagus nerve, an elongated nerve in the autonomic nervous system, controls a number of physiological processes in humans, including blood pressure, breathing rate, vasomotor activity, and certain reflex movements. Recent bioelectronic research has led to clinical tests using VNS for inflammatory diseases and other conditions. By sending steady, gentle electric impulses through the vagus nerve to the brain, bioelectronic devices can activate the vagus nerve. The integration of artificial intelligence (AI) with bioelectronic medicine is transforming drug development processes. AI technology can accelerate or even eliminate many time-consuming tasks, allowing healthcare professionals to use their time more efficiently and ultimately improving healthcare outcomes. This review discusses the vagus nerve’s roles in inflammation, stimulation, and regulation in animal models, as well as its therapeutic potential in treating human inflammation. Additionally, it examines how AI-powered bioelectronic drugs are being explored for conditions such as paralysis and immune disorders, and addresses the challenges of delivering large molecules using these drugs. The article emphasizes current trends, advancements, and the promising future applications of combining AI with bioelectronic medicine.

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