Epilepsy and paroxysmal conditions

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Interpreting of electroencephalographic (EEG) elements in patients with epileptic and non-epileptic seizures, neurological complaints, is still a subject of debates until this day. Broad sharp waves (BSW) are rarely recognizable EEG pattern, not applicated, currently in an international directory of clinical electroencephalography. The aim of our study was the primary, a retrospective survey of pediatric patients (3 to 18 years) to confirm or to refute the data that plays a pattern BSW has the predictive value for the detection of epilepsy, and that it can be named as independent pattern in the EEG references. Matherials and methods. There were made 244 routine electroencephalography in length from 15 to 40 minutes for children aged 3 to 18 years from March 2013 to March 2014. That children were the patients of Psychoneurology department in Toushinskaya Childhood City Hospital, study was conducted at the child in a state of restful alertness of the patient and included the routine recording and three functional tests: a test with a closingopening eye; photostimulation and hyperventilation for three minutes. Data were analyzed retrospectively, and included the collection of these data – age, sex of the child, the type of dominant EEG rhythm, frequency of the alpha rhythm, guides and complaints diagnoses at admission, the presence of one or another of epileptic activity on the EEG localization of pathological elements on EEG, changes in the imaging, neurological clinic patient complaints. Results. Broad sharp wave pattern (BSW) was detected in 31 (12.7%) patient's routine EEG of 244 collected during the calendar year. BSWs were localized in the fronto-temporal region in 12 cases, in 12 cases – in the fronto-central region. Wherein – at least in 7 (22.6%) out of 31 cases were found changes during neuroimaging of the brain of the patient. In 6 cases, the admission of the child was developed by a generalized tonic or tonic-clonic seizure, in 4 cases – there were not attacks – there were routine EEGs, in 1 case – a simple dialeptic attack. Conclusions. It can be presumed that the BSW – specific focal pattern registrering in the EEG in patients, mainly with complaints of epileptic character, in anamnaesis morbie, the predominantly observed generalized clonic-tonic and / or tonic seizures. Quite often, during neuroimaging at these patients there have been revealed various changes. The BSWs is mainly characteristic of the frontal, frontotemporal or fronto-central regions. Thus, the pattern stitch is likely to play a predictive value for the detection of epilepsy, as an indicator of acute and / or remote brain damage. Pattern BSW requires further study, the randomized treatment and cross-sectional studies of patients and in the future may be may be recognized as an independent pattern.

About the Authors

I. G. Kovalev
City Children's polyclinic № 88, Moscow; Institute of Pharmacology named V.V. Zakusov, Moscow
Russian Federation

Kovalev Ivan Georgievich – neurologist, a graduate student, Research Institute named after VV Zakusov.

Address: ul. Baltijskaja, 8, Moscow, Russia, 125315

I. L. Stepanishhev
Children's City Clinical Hospital named after ZA Bashlyaeva, Moscow; Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation

Stepanishhev Igor' L'vovich – MD, neurologist, head of psychoneurology Children's City Clinical Hospital named after ZA Bashlyaeva.

Address: ul. Geroev Panfilovcev,Moscow,Russia, 125373.

V. P. Zykov
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation

Zykov Valerij Petrovich – MD, Professor, Head of the Department of Neurology of Childhood; 

Address: ul. Barrikadnaja, d. 2/1, Moscow, Russia, 125993. 

T. A. Voronina
Children's City Clinical Hospital named after ZA Bashlyaeva, Moscow
Russian Federation

Voronina Tat'jana Aleksandrovna – MD, Professor, Honored Scientist, Head of Laboratory of Pharmacology Psychopharmacology. 

Address: ul. Baltijskaja, 8, Moscow, Russia, 125315. 


1. Gusev E.I., Gekht A.B., Khauzer V.A., Mil'chakova L.E., Churilin Yu.Yu. Epidemiology of epilepsy in Russia [Epidemiologiya epilepsii v Rossii (in Russian)]. 2011; 77-84.

2. Mukhin K.Yu., Petrukhin A.S., Mironov M.B. Epileptic syndromes. Diagnosis and Therapy. Reference Guide for physicians [Epilepticheskie sindromy. Diagnostika i terapiya. Spravochnoe rukovodstvo dlya vrachei (in Russian)]. Moscow. 2008.

3. Petrukhin A.S., Mukhin K.Yu., Blagosklonova N.K., Alikhanov A.A. Epileptology childhood [Epileptologiya detskogo vozrasta (in Russian)]. Moscow. 2000; 623 s.

4. Avoli M., Gloor P., Kostopoulos G., Gotman J. An analysis of penicillin-induced generalized spike-and-wave discharges using simultaneous recording of cortical and thalamic single units. J Neurophysiol. 1983; 50: 819-37.

5. Bauer G., Bauer R., Dobesberger J., Unterberger I., Ortler M., Ndayisaba J.P., Trinka E. Departments of Neurology, Medical University Innsbruck, Innsbruck, Austria. J Clin Neurophysiol. 2008 Oct; 25 (5): 250-4 Broad sharp waves-an underrecognized EEG pattern in patients with epileptic seizures.

6. Bancaud J., Talairach J., Geier S., Bonis A., Trottier S., Manrique M. Behavioral manifestations induced by electric stimulation of the anterior cingulate gyrus in man. Rev Neurol (Paris). 1976; 132: 705-24.

7. Chatrian G.E., Bergamini L., Dondey M. et al. A glossary of terms most commonly used by clinical electroencephalographers. EEG Clin Neyrophysiol. 1974; 37: 538-548.

8. Eftekhari S., Mehrabi S. et al. BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model. Acta Neurobiol Exp. 2014, 74: 276-287.

9. Francis L. McNaughton – report in issue No. Epilepsia. 1966; 1 (7): 80-82.

10. Geiger L.R., Harner R.N. EEG patterns at the time of focal seizure onset. Arch Neurol. 1978; 35: 276-86.

11. Gloor P. Generalized cortico-reticular epilepsies. Some considerations on the pathophysiology of generalized bilaterally synchronous spike and wave discharge. Epilepsia. 1968 Sep; 9 (3): 249-63.

12. Halasz P. Generalized epilepsy with spikewave paroxysms as an epileptic disorder of the function of sleep promotion. Acta Physiol Acad Sci Hung. 1981; 57 (1): 51-86.

13. Liu J.S., Wang J.H., Zhou J., Tang X.H., Xu L., Shen T., Wu X.Y., Hong Z. Enhanced brain delivery of lamotrigine with Pluronic® P123based nanocarrier. International Journal of Nanomedicine. 2014; 9: 3923-3935.

14. Magnus O. Reunion Europeend’information. Marseille. 1-5 September 1970.

15. Magnus O.,Van der Holst M. Zeta waves: a special type of slow delta waves. EEG Clin Neurophysiol. 1987; 67: 140-146.

16. Marcus E.M., Watson C.W., Simon S.A. An experimental model of some varieties of petit mal epilepsy: electrical-behavioral correlations of acute bilateral epileptogenic foci in cerebral cortex. Epilepsia. 1968; 9: 233-248.

17. Meldrum B.S., Rogawski M.A. Molecular Targets for Antiepileptic Drug Development. Neurotherapeutics. 2007 January; 4 (1): 18-61.

18. Noachtar S., Binnie C., Ebersole J. et al. A glossary of terms most commonly used by clinical electro encephalographers and proposal for the report form for the EEG findings. In: Deuschl G., Eisen A., eds. Reccomendations for the Practice of Clinical Neurophysiology: Guidelines of the International Federation of Clinical Neurophysiology. 2nd ed. Amsterdam. 1999: 21-41.

19. Pollen D.A., Perot P., Reid K.H. Experimental bilateral wave and spike from thalamic stimulation in relation to level of arousal. Electroenceph clin Neurophysiol. 1963; 15: 1017-1028.

20. Stefan H., Snead O.C. In: Engel J., Pedley T.A., editors. Epilepsy: a comprehensive textbook. Philadelphia. 1997: 79-590.

21. Timofeev I., Steriade M. Neocortical seizures: initiation, development and cessation. Neuroscience. 2004; 123: 299-336.

22. Williams D.A. Study of thalamic and cortical rhythms in petit mal. Brain. 1953; 76: 50-69.


For citations:

Kovalev I.G., Stepanishhev I.L., Zykov V.P., Voronina T.A. CLINICAL DIAGNOSTIC VALUE OF OBSCURE ELECTROENCEPHALOGRAPHIC PATTERN "BROAD SHARP WAVE" IN CHILDREN. Epilepsy and paroxysmal conditions. 2015;7(3):6-17. (In Russ.)

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