INCIDENCE OF PHARMACORESISTANT EPILEPSY IN KRASNOYARSK REGION (according to neurological center of university hospital data)
Abstract
The goal of this study was to evaluate the incidence of cases pharmacoresistant varying severity in different forms of epilepsy among residents of Krasnoyarsk and the Krasnoyarsk region. We also analyzed the electronic database of Neurological Centre of Epileptology, Neurogenetics and Brain Research at University Hospital in 2008-2010. Random sample from the database was 199 cases of epilepsy initially aimed by neurologists or advised on seizures which is a difficult to control (pharmacoresistant?). We have shown that number of true pharmacoresistant cases in the studied sample did not reach 1 / 3 of cases (53/199, 26.6%) after adjustment of therapy. Thus, a personalized approach to treatment of epilepsy at Neurological Centre of Epileptology, Neurogenetics and Brain Research was the way to reduce pharmacoresistant cases.
About the Authors
N. A. Shnayder
SEG HPGE “Krasnoyarsk State Medical University named after prof. VF Voynoasenetsky “ of Ministry of Health and Social Development of the Russian Federation
Russian Federation
Russian Federation
M. S. Pilugina
SEG HPGE “Krasnoyarsk State Medical University named after prof. VF Voynoasenetsky “ of Ministry of Health and Social Development of the Russian Federation
Russian Federation
Russian Federation
D. V. Dmitrenko
SEG HPGE “Krasnoyarsk State Medical University named after prof. VF Voynoasenetsky “ of Ministry of Health and Social Development of the Russian Federation
Russian Federation
Russian Federation
E. N. Shmatova
SEG HPGE “Krasnoyarsk State Medical University named after prof. VF Voynoasenetsky “ of Ministry of Health and Social Development of the Russian Federation
Russian Federation
Russian Federation
S. A. Erikalova
SEG HPGE “Krasnoyarsk State Medical University named after prof. VF Voynoasenetsky “ of Ministry of Health and Social Development of the Russian Federation
Russian Federation
Russian Federation
References
1. Броди М.Дж. Общеевропейские стандарты помощи при эпилепсии / М.Дж. Броди, Д. Шорвон, С. Йоханнессен и др. // Информационный бюллетень. – 1998. – 131с.
2. Власов П.Н. Некоторые практические аспекты терапии эпилепсии у взрослых // Consil. Medicum. - 2004. – Т. 6, № 2 – С. 74-82.
3. Вольф П. Фармакорезистентность и эпилепсия // Международный неврологический журнал. – 2006. – Т. – 8, № 4
4. Гехт А.Б. Современные стандарты диагностики и лечения эпилепсии в Европе / А.Б. Гехт, Г.Н. Авакян, Е.И. Гусев // Журн. неврол. и психиатр. – 1999. - № 7. – С.4-7.
5. Дзяк Л.А., Зенков Л.Р., Кириченко А.Г. Эпилепсия. – К.: Книга-плюс, 2001. – 168с.
6. Дмитренко Д.В. Клинико-эпидемиологическая характеристика эпилепсии с поздним дбютом в Красноярске (по данным госпитального регистра): Автореф. дис. … канд. мед. наук. Иркутск, Красноярск, 2007 – 29с.
7. Карлов В.А. Развитие эпилепсии на современном этапе // Достижения, перспективы и вопросы терапии эпилепсии: Материалы Конгресса эпилептологов, Израиль: Иерусалим, 3-5 марта – 2010. - С.1-2.
8. Шнайдер Н.А., Дмитренко Д.В. Алгоритмы диагностики и лечения эпилепсии с поздним дебютом. – Красноярск. - 2007. – 38 с.
9. Шнайдер Н.А., Дмитренко Д.В., Пилюгина М.С. Фармакогенетика антиэпилептических препаратов // Бюллетень сибирской медицины. - 2008. - №4. - С. 111-118.
10. Bourgeois B.F.D. General concepts of medical intractability. In: Luders HO. Epilepsy Surgery. New York: Raven Press, 1992: 77–82.
11. Brodie M.J. Antiepileptic drugs: past, present and future // Abstract Book 7th Asian & Oceanian Epilepsy Congress, China, 2008. – P. 3.
12. Feely M. Drug treatment of epilepsy // British Medical Journal, 1999. – V. 318(9). – P. 106-109.
13. Fisher R.S., van Emde Boas W., Elger C., Genton P., Lee P. et al. Epileptic seizures and epilepsy definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) // Epilepsia – 2005. – V. 46. – P. 470-472.
14. Jallon P. Epidemiology of epilepsies. // In Panayiotopoulos C.P., ed. V. 1: A practical guide to childhood epilepsies. – Oxford: Medicinae: 2006. – P. 17-20.
Review
For citations:
Shnayder N.A., Pilugina M.S., Dmitrenko D.V., Shmatova E.N., Erikalova S.A. INCIDENCE OF PHARMACORESISTANT EPILEPSY IN KRASNOYARSK REGION (according to neurological center of university hospital data). Epilepsy and paroxysmal conditions. 2010;2(4):32-36. (In Russ.)
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