Epilepsy and paroxysmal conditions

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Vol 2, No 4 (2010)


12-22 303
In current specialized literature for doctors today there is a lack of data on the incidence of neurological morbuduty in a hospital environment. The attempt to fill this gap of information for assessing the incidence was conducted based on data from medical records, patients referred for assessment and treatment in a city hospital from 2000 to 2009. Identified patterns and trends can be useful for planning of utilization of health care facilities (HCF), employment of medical personnel and the procurement of medicines, as well as for scientific researches design development.
23-31 370
Medical manipulations on epileptic patients are associated with risk of occurrence of seizures. However, such risk is often overestimated. In 902 epileptic patients examined, only 3 epileptic seizures were recorded, which have occurred during surgical intervention under general anesthesia. This article presents data on the effects of systemic anesthetics, surgical intervention itself and concomitant medicinal treatment over occurrence of epileptic seizures. The issues of epileptic patients’ preparation for elective surgery are discussed.
32-36 378
The goal of this study was to evaluate the incidence of cases pharmacoresistant varying severity in different forms of epilepsy among residents of Krasnoyarsk and the Krasnoyarsk region. We also analyzed the electronic database of Neurological Centre of Epileptology, Neurogenetics and Brain Research at University Hospital in 2008-2010. Random sample from the database was 199 cases of epilepsy initially aimed by neurologists or advised on seizures which is a difficult to control (pharmacoresistant?). We have shown that number of true pharmacoresistant cases in the studied sample did not reach 1 / 3 of cases (53/199, 26.6%) after adjustment of therapy. Thus, a personalized approach to treatment of epilepsy at Neurological Centre of Epileptology, Neurogenetics and Brain Research was the way to reduce pharmacoresistant cases.
37-40 1039
Purpose: Studing seizure in patients with Chiari I malformation. Methods: 111 patients (58 females, 53 males) with Arnold-Chiari I malformation and epilepsy were examined with cognitive and behavioral examinations, EEG, MRI. Results: Patients with Arnold-Chiari I malformation have been next forms epilepsy: symptomatic epilepsy – 53,9%, cryptogenic epilepsy – 43,4%, juvenile мyoclonic epilepsy – 0,9%, juvenile absence epilepsy – 1,8%. The neurological symptoms were: cranial nerve dysfunction – 27%, the pyramidal symptoms – 12,6%, cerebellar symptoms – 0,9% and 59,5% patients have not neurological signs. The radiological features are: association of small posterior cranial fossa volume and Arnold-Chiari I malformation – 6%, association basilar impression and Arnold-Chiari I malformation with small posterior cranial fossa volume – 2%, basilar impression and Arnold-Chiari I malformation – 1%. Conclusion. The Arnold-Chiari I malformation, basilar impression and small posterior cranial fossa volume are anatomic finds in the MRI examinations in patients with epilepsy.


41-54 421
This article reviews the issues of experimental and clinical epileptology. For the development and implementation of new medications and technologies of medicinal interventions, as well as investigation of main “targets” for anti-epileptic drugs, it is necessary to develop the experimental models of various forms of epilepsy and epileptic seizures. To this end, we studied the alterations of cerebral electrical activity in rats with chronic cobalt epileptogenic focus which represents an optimal experimental model of epileptic state. The significance of hypothalamus was shown to be the lead (determinate) structure within the pathologic epileptic system during formation of secondary generalized seizures. The drug” targets” and possibilities for combined administration of anticonvulsants and antioxidants have been revealed. Pharmaco-genetic investigations enable us to predict the effects of different antiepileptic drugs.

ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)