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Epilepsy and paroxysmal conditions

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EXPERIMENTAL AND CLINICAL EPILEPTOLOGY

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Abstract

This article reviews the issues of experimental and clinical epileptology. For the development and implementation of new medications and technologies of medicinal interventions, as well as investigation of main “targets” for anti-epileptic drugs, it is necessary to develop the experimental models of various forms of epilepsy and epileptic seizures. To this end, we studied the alterations of cerebral electrical activity in rats with chronic cobalt epileptogenic focus which represents an optimal experimental model of epileptic state. The significance of hypothalamus was shown to be the lead (determinate) structure within the pathologic epileptic system during formation of secondary generalized seizures. The drug” targets” and possibilities for combined administration of anticonvulsants and antioxidants have been revealed. Pharmaco-genetic investigations enable us to predict the effects of different antiepileptic drugs.

About the Authors

G. N. Avakyan
GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
Russian Federation


O. L. Badalyan
GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
Russian Federation


S. G. Burd
GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
Russian Federation


Е. А. Valdman
GU scientific research institute of pharmacology named after V.V. Zakusov of RAMS
Russian Federation


Т. А. Voronina
GU scientific research institute of pharmacology named after V.V. Zakusov of RAMS
Russian Federation


L. N. Nerobkova
GU scientific research institute of pharmacology named after V.V. Zakusov of RAMS
Russian Federation


Е. V. Krikova
GU scientific research institute of pharmacology named after V.V. Zakusov of RAMS
Russian Federation


G. G. Аvakyan
GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
Russian Federation


A. S. Chukanova
GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
Russian Federation


M. I. Stoyko
GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
Russian Federation


А. А. Savenkov
GOU VPO “Russian state medical university named after N.I. Pirogov” of Roszdrav
Russian Federation


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For citation:


Avakyan G.N., Badalyan O.L., Burd S.G., Valdman Е.А., Voronina Т.А., Nerobkova L.N., Krikova Е.V., Аvakyan G.G., Chukanova A.S., Stoyko M.I., Savenkov А.А. EXPERIMENTAL AND CLINICAL EPILEPTOLOGY. Epilepsy and paroxysmal conditions. 2010;2(4):41-54. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)