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In this paper we are discussing the issues of diagnosis, classification, features of preoperative evaluation and surgical treatment of focal cortical dysplasia in children. Particular attention is paid to the complexities of visualization of FCD, as well as the reasons of frequent poor postoperative outcomes in epilepsy associated with FCD.

About the Author

S. O. Ayvazyan
GU the Scientifically-practical centre of medical aid to children PHD of Moscow
Russian Federation


1. Алиханов А.А., Никаноров А.Ю., Мухин К.Ю., Айвазян С.О. Фокальная корковая дисплазия у больного с эпилептическими приступами. Журнал неврологии и психиатрии им. С.С. Корсакова. 1998; 7: 45-47.

2. Barkovich A.J. Congenital malformations of the brain and skull. In: Barkovich A.J., ed. Pediatric neuroimaging. 4th ed. Philadelphia: Lippincott, Williams & Wilkins. 2005; 291-439.

3. Barkovich A.J., Kuzniecky R.I., Bollen A.W., Grant P.E. Focal transmantle dysplasia: a specific malformation of cortical development. Neurology. 1997; 34: 369-387.

4. Blümcke I., Thom M., Aronica E. et al. The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia. 2011; 52(1): 158-174.

5. Duchowny M. Clinical, functional, and neurophysiologic assessment of dysplastic cortical networks: Implications for cortical functioning and surgical management. Epilepsia. 2009 Oct; 50 Suppl 9:19-27.

6. Ferrier C.H., Aronica E., Leijten F.S., Spliet W.G., Boer K., van Rijen P.C., van Huffelen A.C. Electrocorticography discharge patterns in patients with a cavernous hemangioma and pharmacoresistent epilepsy. J. Neurosurg. 2007; 107: 495-503.

7. Harvey S.A., Mathern G., Nordli D., Cross H. Epilepsy Surgery in Children: Results from an International Survey. Epilepsia. 2005; 46(Suppl. 6): 82.

8. Krsek P., Maton Bruno, Korman B. et al. Different features of histopathological subtypes of pediatric focal cortical dysplasia. Ann Neurol. 2008; 63:758-769.

9. Lawson J.A., Birchansky S., Pacheco E., Jayakar P., Resnick T.J., Dean P., Duchowny M.S.. Distinct clinicopathologic subtypes of cortical dysplasia of Taylor. Neurology. 2005 Jan 11; 64(1): 55-61.

10. Palmini A., Luders H.O. Classification issues in malformations caused by abnormalities of cortical development. Neurosurgery Clinics of North America. 2002; 13: 1-16.

11. Palmini A., Najm I., Avanzini G. et al. Terminology and classification of the cortical displasias. Neurology. 2004; 62 (suppl 3): 2-8.

12. Palmini A., Andermann F., Olivier A., Tampieri D., Robitaille Y. Focal neuronal migration disoders and intractable partial epilepsy^ results oа surgical treatment. Ann Neurology. 1991; 30: 750-757.

13. Taylor D.C., Falconer M.A., Bruton C.J., Corsellis J.A. Focal dysplasia of the cerebral cortex in epilepsy. J. Neurol Neurosurg Psychiatry. 1971; 34: 369-387.


For citations:

Ayvazyan S.O. FOCAL CORTICAL DYSPLASIA: ALGORITHM OF PREOPERATIVE EXAMINATION. Epilepsy and paroxysmal conditions. 2012;4(2):6-12. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)