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EXPERIENCE OF PROLONGED VALPROATE USE IN ADULT PATIENTS WITH FOCAL FORMS OF EPILEPSY (RESULTS OF OBSERVATION HELD IN OUT-PATIENT CLINICS OF MOSCOW)

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Abstract

Results of Depakine Chronosphere use in Moscow city out-patient clinics are demonstrated in the article. 48 patients with focal forms of epilepsy (cryptogenic and symptomatic) were examined: 32 men and 16 women in age of 16 - 59 years with different duration of disease and different types of seizures. Depakine Chronosphere was indicated to patients who were already taking antiepileptic drugs in monotherapy with efficacy of 50% and more, and also to patients with drug remission, but with side effects, requiring changes of current indications. Results of the observation demonstrated high efficacy of Depakine Chronosphere in adult patients with different forms of focal epilepsy in monotherapy and also its use possibility in case of noneffective or poor tolerability of other valproates and carbamazepine.

About the Authors

S. G. Burd
Chair of neurology and neurosurgery GBOU VPO Russian National Investigational Medical University named after N.I. Pirogov, Ministry of Health and Social Development of the Russian Federation (Moscow)
Russian Federation


A. V. Lebedeva
Chair of neurology and neurosurgery GBOU VPO Russian National Investigational Medical University named after N.I. Pirogov, Ministry of Health and Social Development of the Russian Federation (Moscow)
Russian Federation


I. Yu. Artyomova
Moscow City Polyclinics
Russian Federation


O. L. Badalyan
Moscow City Polyclinics
Russian Federation


M. A. Bogomazova
Moscow City Polyclinics
Russian Federation


I. I. Zhuravlyeva
Moscow City Polyclinics
Russian Federation


A. M. Ismailov
Moscow City Polyclinics
Russian Federation


E. G. Komelkova
Moscow City Polyclinics
Russian Federation


L. N. Lesinker
Moscow City Polyclinics
Russian Federation


Yu. I. Logvinov
Moscow City Polyclinics
Russian Federation


O. V. Otcheskaya
Moscow City Polyclinics
Russian Federation


S. V. Petrov
Moscow City Polyclinics
Russian Federation


Yu. V. Solomatin
Moscow City Polyclinics
Russian Federation


A. M. Teplysheva
Moscow City Polyclinics
Russian Federation


T. N. Vdovichenko
Moscow City Polyclinics
Russian Federation


E. A. Khromykh
Moscow City Polyclinics
Russian Federation


A. S. Chukanova
Moscow City Polyclinics
Russian Federation


A. N. Boiko
Chair of neurology and neurosurgery GBOU VPO Russian National Investigational Medical University named after N.I. Pirogov, Ministry of Health and Social Development of the Russian Federation (Moscow)
Russian Federation


References

1. Белоусова Е.Д. с соавт. Неврология нейропсихиатрия и психосоматика. 2009; (3-4): 25-32.

2. Зенков Л.Р., Яхно Н.Н., Усачева Е.Л. Депакин хроно в лечении эпилепсии, резистентной к другим препаратам. Неврологический журнал. 2000; 5 (4): 39-42.

3. Bergmann A., Schmidt D., Hutt H.J., Elger C.E. Epilepsy treatment with a sustanedrelease formulation of valproate - experience with 1172 patients. Actuelle Neurologie. 1999; 26: 1-5.

4. Bialer M. CNS Drugs. 2007; 21(9): 765-74.

5. Owens M.J., Nemeroff C.B. Psychopharmacol Bull. 2003; 37 (2): 17-24.

6. Pierre-Louis S.J., Brannegan R.T., Evans A.T. Clin Neurol Neurosurg. 2009 Jun;111(5): 437.

7. Smith M.C., Centorrino F., Welge J.A., Collins M.A. Epilepsy Behav. 2004 Oct; 5 (5): 746- 51.

8. Todorovic S.M , Lingle C J. J. Neurophysiol. 1998 Jan;79 (1): 240-52.

9. Yu P.M., Zhu G.X , Wu X.Y., Li T., Xu L., Yue L., Wang B., Hong Z. Seizure. 2011 Jan; 20 (1): 23-6.


For citation:


Burd S.G., Lebedeva A.V., Artyomova I.Y., Badalyan O.L., Bogomazova M.A., Zhuravlyeva I.I., Ismailov A.M., Komelkova E.G., Lesinker L.N., Logvinov Y.I., Otcheskaya O.V., Petrov S.V., Solomatin Y.V., Teplysheva A.M., Vdovichenko T.N., Khromykh E.A., Chukanova A.S., Boiko A.N. EXPERIENCE OF PROLONGED VALPROATE USE IN ADULT PATIENTS WITH FOCAL FORMS OF EPILEPSY (RESULTS OF OBSERVATION HELD IN OUT-PATIENT CLINICS OF MOSCOW). Epilepsy and paroxysmal conditions. 2012;4(2):56-66. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)