CHANGES OF PERIFERAL BLOOD PARAMETERS AND IMMUNOLOGICAL STATUS OF PATIENTS WITH CHRONICAL HERPETIC INFECTION WITHOUT ANT WITH SYMPTOMATIC FOCAL EPILEPSY

Full Text:


Abstract

Abstract: Purpose of the study is аssessment of changes in the peripheral blood parameters and immune status of patients with chronic herpes infection without and with symptomatic (parainfection) focal epilepsy. Materials and Metods. the study included 128 adults. Group 1 – control (40 pers.; median age – 31 ye.o., 2 group – patients with chronic herpes virus infection without symptomatic focal epilepsy (43 pers.; median age – 35 ye.o.). 3 group – patients with chronic herpes virus infection complicated by symptomatic focal epilepsy (45 pers.; median age – 32 ye.o.). Volume of research: history of the disease, epidemiological history, neurological examination, video-EEG monitoring, MRI, MR-spectroscopy, immune status, serology, immunologist consultation. Results. The analysis of immune status of the patients with chronic herpes infection has shown significant differences between the studied parameters compared with the control group, as well as comparisons between groups. We were shown lymphocytosis, imbalance of immunoregulatory subpopulations, reducing the immunoregulatory index. Serological studies in patients 2 and 3 groups of 100% of the cases were shown specific G class antibodies to HSV, a high titer of antibodies found in patients 2 groups accession symptomatic focal epilepsy, p <0.01. Also, the study was shown a reduce of Ig A level in groups 2 and 3 compared with the control. Statistically significantly more frequently in patients two groups met chronic recurrent herpesvirus mixed infection. Conclusions. The patients with chronic herpes infection with symptomatic focal epilepsy revealed more serious violations in the humoral and cellular immunity, adversely affecting the formation of specific antiviral response. This testifies to the prolonged course of infection , which is a predictor of high risk of forming refractory symptomatic (parainfection ) focal epilepsy.

About the Authors

S. V. Krijzhanovskaya
Siberian Clinical Center of Federal Medical – Biologial Agency of Russia, Krasnoyarsk; Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of Health Care Ministry of Russian Federation
Russian Federation


N. L. Kamzalakova
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of Health Care Ministry of Russian Federation
Russian Federation


N. A. Shnayder
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of Health Care Ministry of Russian Federation
Russian Federation


Yu. S. Panina
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University of Health Care Ministry of Russian Federation
Russian Federation


References

1. Dekonenko E.P., Leont eva I.Ja., Martynenko I.N. i dr. Recidivirujushhij gerpeticheskij jencefalit u detej: opisanie sluchaja i obzor literatury. Nevrolog. zhurn. 2008; 13 (5): 19-25.

2. Shnajder N.A., Dmitrenko D.V., Dyhno Ju.A. i dr. Problemy diagnostiki paraneoplasticheskogo limbicheskogo jencefalita. Jepilepsija i paroksizmal nye sostojanija. 2013; 3; 41-48.

3. Red kin, Ju.V. Odokienko A.Ju. Biologicheskie osobennosti virusa prostogo gerpesa i vozmozhnosti farmakoterapii. Uspehi sovremennoj biologii. 2006; 126 (1): 87-96.

4. Naslednikova I.O., Rjazanceva N.V., Novickij V.V. i dr. Disbalans immunoreguljatornyh TN1- i TN2-citokinov pri persistentnyh virusnyh infekcijah Med. immunologija. 2007; 9 (1): 53-60.

5. Vasil ev A.N., Fedorova N.E., Klimova R.R. i dr. Sovershenstvovanie diagnostiki gerpes-virusnyh infekcij. Klin. lab. diagnostika. 2012; 6: 52-55.

6. Lavrov V.F., Koval chuk L.V., Gankovskaja L.V. i dr. Estestvennyj immunitet i gerpeticheskaja infekcija. Vopr. virusologii. 2006; 51 (3): 3-9.

7. Harlamova F.S., Egorova N.Ju., Guseva L.N. i dr. Virusy semejstva gerpesa i immunitet. Detskie infekcii. 2006; 5 (3); 3-10.

8. Basaeva Zh.P., Beljaeva L.V., Tkachenko E.I. Vozrastnye osobennosti gerpes-specificheskogo immuniteta detej s vtorichnymi immunodeficitnymi sostojanijami. Klin. lab. diagnostika. 2008; 9: 80a-80.

9. Murugin V.V., Zujkova I.N., Murugina N.E. i dr. Deficit degranuljacii NK-kletok u bol nyh hronicheskoj recidivirujushhej gerpes-virusnoj infekciej. Immunologija. 2010; 6: 228-231.

10. Cherevko N.A., Popova I.S., Klimov V.V. i dr. Osobennosti izmenenija populjacionnogo immuniteta naselenija na fone gepres-inficirovanija. Ros. allergolog. zhurn. 2010; 1 (1): 207-208.

11. Pron kina N.S., Bulygin G.V., Kamzalakova N.I. i dr. Harakteristika parametrov immunnogo statusa u bol nyh hronicheskoj gerpeticheskoj infekciej s formirovaniem sindroma hronicheskoj ustalosti i immunnoj disfunkcii. Fundamental nye issled. 2013; 5 (1); 124-128.

12. Sokolova T.F., Minakova E.Ju., Dolgih T.I. Izuchenie immunofenotipa limfocitov u pacientov s mikst-infekciej, vyzvannoj virusami semejstva Herpes viridae. Med. immunologija. 2010; 12 (4-5): 433-436.

13. Adamo M.A., Abraham L., Pollack I.F. Chronic granulomatous herpes encephalitis: a rare entity posing a diagnostic challenge. J. Neurosurg. Pediatr. 2011; 8 (4): 402-406.

14. Adler A.C, Kadimi S., Apaloo C. et al. Herpes simplex encephalitis with two false-negative cerebrospinal fluid PCR tests and review of negative PCR results in the clinical setting. Case Rep. Neurol. 2011; 3 (2): 172-178.

15. Ahmed R., Kiani I.G., Shah F. et al. Herpes simplex encephalitis presenting with normal CSF analysis. J. Coll. Physicians Surg. Pak. 2013; 23 (10): 815-817.

16. Akhan S.C, Coskunkan F., Mutlu B. et al. A probable case of herpes simplex encephalitis despite negative PCR findings. Infection. 2001; 29 (6): 359-361.

17. Aurelius E., Johansson B., Skцldenberg B. et al. Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid. Lancet. 1991; 337 (8735): 189-192.

18. Csonka T., Szepesi R., Bidiga L. et al. The diagnosis of herpes encephalitis – a case-based update. Ideggyogy Sz. 2013; 66 (9-10): 337-342.

19. De Tiиge X., De Laet C., Mazoin N. et al. Postinfectious immune-mediated encepha-litis after pediatric herpes simplex ence-phalitis. Brain Dev. 2005; 27 (4): 304-307.

20. De Tiиge X., Rozenberg F., Burlot K. et al. Herpes simplex encephalitis: diagnostic problems and late relapse. Dev. Med. Child Neurol. 2006; 48 (1): 60-63.

21. Devrim I., Tezer Н., Haliloğlu G. et al. Relapsing Herpes simplex virus encephalitis despite high-dose acyclovir therapy: a case report. Turk. J. Pediatr. 2008; 50 (4): 380-382.

22. Ito Y., Kimura H., Yabuta Y. еt al. Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir. Clin. Infect. Dis. 2000; 30 (1): 185-187.

23. Lellouch-Tubiana A., Fohlen M., Robain O. et al. Immunocytochemical characterization of long – term persistent immune activation in human brain after herpes simplex encephalitis. Neuropathol. Appl. Neurobiol. 2000; 26 (3): 285-294.

24. Love S., Koch P., Urbach H., Dawson T.P. Chronic granulomatous herpes simplex encephalitis in children. J. Neuropathol. Exp. Neurol. 2004; 63 (11): 1173-1181.

25. Skцldenberg B. Herpes simplex encephalitis. Scand. J. Infect. Dis. Suppl. 1996; 100: 8-13.

26. Tokumaru A.M., Horiuchi K., Kaji T. et al. MRI findings of recurrent herpes simplex encephalitis in an infant. Pediatr. Radiol. 2003; 33 (10): 725-728.

27. Utumi Y., Iseki E., Murayama N. еt al. Limbic encephalitis caused by herpes simplex virus infection after vaccination against the influenza virus. Brain Nerve. 2010; 62 (6): 615-619.

28. Whitley R.J. Herpes simplex encephalitis: adolescents and adults. Antiviral Res. 2006; 71 (2-3): 141-148.


Supplementary files

For citation: Krijzhanovskaya S.V., Kamzalakova N.L., Shnayder N.A., Panina Y.S. CHANGES OF PERIFERAL BLOOD PARAMETERS AND IMMUNOLOGICAL STATUS OF PATIENTS WITH CHRONICAL HERPETIC INFECTION WITHOUT ANT WITH SYMPTOMATIC FOCAL EPILEPSY. Epilepsia and paroxyzmal conditions. 2014;6(1):49-56.

Views: 111

Refbacks

  • There are currently no refbacks.


ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)