NEUROIMMUNOPATHOGENIC MECHANISMS OF EPILEPSY

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Abstract

Abstract: the characteristics of some immunological Features were studied in 52 patients with epilepsy. The group of control included 10 healthy subjects of the comparable age.There were studied such immunological aspects in this group of patients as level of neurotropic autoantibodies to NF-200, GPAP, S100, common protein of myelin, Voltage-dependent Ca canals, glutamate receptors, GAMK-, Dofamine, Serotonin and N-choline-receptors.Neuroimmune reorganizing in epilepsy is accompanied by increase in autoantibodies to receptors of GAML, dofamine and borderline deviations to protein B2 glycoprotein. However, more reliableparameters in relation to indicators of control group there were noted in the contents of autoantibodies to such neurospecific proteins as: NF-200, S100 and to two-spiral DNA. This indicated about degenerative disorders of axonal type in the brain of the patients with epilepsy.

About the Authors

Yо. N. Madjidova
Tashkent Pediatric Medical Institute; Tashkent Medical Academy
Uzbekistan


G. S. Rakhimbaeva
Tashkent Pediatric Medical Institute; Tashkent Medical Academy
Uzbekistan


R. B. Azizova
Tashkent Pediatric Medical Institute; Tashkent Medical Academy
Uzbekistan


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Supplementary files

For citation: Madjidova Y.N., Rakhimbaeva G.S., Azizova R.B. NEUROIMMUNOPATHOGENIC MECHANISMS OF EPILEPSY. Epilepsia and paroxyzmal conditions. 2014;6(1):15-18.

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